Side Effects of tedizolid: A Synthesis of Findings from 15 Studies

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Original Abstract of the Article

Major Research Findings

Tedizolid is a new oxazolidinone antibiotic that has been shown to be effective against a wide range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). 7 . Tedizolid has been shown to be non-inferior or even superior to linezolid, a common treatment option, with fewer side effects. 4 . Tedizolid’s once-daily dosing regimen can potentially reduce the burden on patients. 7 . Tedizolid has also shown a lower risk of thrombocytopenia and gastrointestinal side effects compared to linezolid. 4 . Additionally, tedizolid appears to have a lower potential for interaction with monoamine oxidase inhibitors. 15 .

Reasons for Side Effects

Tedizolid exerts its antibacterial effect by inhibiting bacterial protein synthesis in mitochondria. 6 . This effect on mitochondrial function could lead to side effects such as thrombocytopenia. 6 . However, tedizolid has shown weaker binding to mitochondria compared to linezolid, which may indicate a lower risk of side effects. 5 .

Common Side Effects

Gastrointestinal

The most common side effect of tedizolid is gastrointestinal issues, including nausea, vomiting, and diarrhea. 4 . Tedizolid has shown a lower incidence and delayed onset of these side effects compared to linezolid. 8 .

Hematologic

Tedizolid, similar to linezolid, can cause thrombocytopenia (low platelet count). 4 . However, studies have shown a lower risk of thrombocytopenia with tedizolid compared to linezolid. 4 .

Side Effects Management

Gastrointestinal

Management of gastrointestinal side effects can involve dietary adjustments or medication. 8 . It is important to follow your doctor's instructions and implement appropriate measures.

Hematologic

If thrombocytopenia occurs, blood tests will be performed, and treatment, such as blood transfusions, may be necessary. 8 . Regularly scheduled blood tests are important, following your doctor’s instructions.

Research Comparisons

Commonalities

Multiple studies have shown that tedizolid is non-inferior or superior to linezolid with fewer side effects. 4 , 7 .

Differences

While tedizolid has shown a lower risk of thrombocytopenia and gastrointestinal side effects compared to linezolid, some studies have shown that this difference is not statistically significant. 4 .

Real-life Application Considerations

Tedizolid is an effective treatment option for infections caused by Gram-positive bacteria, including MRSA. However, it is important to be aware of the potential for side effects. 7 . If you experience any changes in your health while taking tedizolid, consult your doctor immediately.

Current Research Limitations

Research on tedizolid is still ongoing, and more studies are needed to understand its long-term safety and effectiveness. 8 .

Future Research Directions

Future research should focus on investigating the long-term safety and effectiveness of tedizolid, its efficacy against different infections, and its potential for drug interactions. 8 .

Conclusion

Tedizolid is a promising new antibiotic for the treatment of infections caused by Gram-positive bacteria, including MRSA. 7 . Tedizolid has shown non-inferiority or superiority to linezolid with potentially fewer side effects. 4 . However, further research is needed to confirm the long-term safety and effectiveness of tedizolid. 8 . If you experience any changes in your health while taking tedizolid, consult your doctor immediately.

Literature analysis of 15 papers
Positive Content
13
Neutral Content
0
Negative Content
2
Article Type
2
0
1
9
15
1.

Symptoms associated with tamoxifen treatment in postmenopausal women.

Author: LoveR R, CameronL, ConnellB L, LeventhalH

Disease-free survival
Gynecological symptoms
Vasomotor symptoms

Tamoxifen therapy in postmenopausal women with breast cancer was associated with significant perceived symptom 'cost', including vasomotor symptoms and gynecologic symptoms, potentially compromising long-term compliance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

Influence of the anti-oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review.

Author: MarinaDjordje, RasmussenÅse Krogh, Buch-LarsenKristian, GillbergLinn, AnderssonMichael, SchwarzPeter

BC recurrence
Thyroid function

Tamoxifen and letrozole are anti-oestrogens used to prevent breast cancer recurrence. While their side effects are well-documented, their impact on thyroid function is less clear. This review explores the potential effects of tamoxifen and letrozole on thyroid function and their contribution to weight gain observed in breast cancer patients.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Safety profiles of old and new antimicrobials for the treatment of MRSA infections.

Author: BassettiMatteo, RighiElda

Lactic acidosis
Myopathy
Nephrotoxicity
Thrombocytopenia

Prolonged use of high-dose vancomycin can lead to nephrotoxicity. Linezolid use can cause lactic acidosis and thrombocytopenia. Daptomycin can cause myopathy. Telavancin has shown increased toxicity compared to vancomycin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Analysis of the phase 3 ESTABLISH trials of tedizolid versus linezolid in acute bacterial skin and skin structure infections.

Author: ShorrAndrew F, LodiseThomas P, CoreyG Ralph, De AndaCarisa, FangEdward, DasAnita F, ProkocimerPhilippe

Skin infection treatment
Low platelet count
Nausea

Tedizolid, a novel oxazolidinone effective against various Gram-positive pathogens, was evaluated in two phase 3 trials for acute bacterial skin and skin structure infections. In a pooled analysis, tedizolid demonstrated noninferior efficacy compared to linezolid, with a favorable tolerability profile. Tedizolid led to fewer cases of low platelet counts and gastrointestinal side effects than linezolid, aligning well with antimicrobial stewardship principles.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function.

Author: FlanaganShawn, McKeeEdward E, DasDebaditya, TulkensPaul M, HosakoHiromi, Fiedler-KellyJill, PassarellJulie, RadovskyAnn, ProkocimerPhilippe

Less myelosuppression
Less neuropathy
Lactic acidosis
Mitochondrial inhibition

This study compares the potential of tedizolid and linezolid, two oxazolidinone antibiotics, to cause myelosuppression, lactic acidosis, and neuropathies. Results suggest that tedizolid may have less potential for these mitochondriopathic side effects than linezolid.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Tedizolid: The First Once-Daily Oxazolidinone Class Antibiotic.

Author: BurdetteSteven D, TrotmanRobin

ABSSSI treatment

Tedizolid phosphate is a novel oxazolidinone antibiotic that is dosed once daily and has been shown to be noninferior to linezolid for the treatment of acute bacterial skin and skin structure infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

New developments in the management of severe skin and deep skin structure infections - focus on tedizolid.

Author: DurkinMichael J, CoreyG Ralph

ABSSSI treatment
Nausea
Thrombocytopenia

Tedizolid is a novel oxazolidinone approved for treating acute bacterial skin and skin structure infections. It has a prolonged half-life, broad-spectrum activity, and high oral bioavailability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

The role of tedizolid in skin and soft tissue infections.

Author: BouzaEmilio, MuñozPatricia, BurilloAlmudena

SSTI treatment

Tedizolid is a second-generation oxazolidinone that is effective against Gram-positive bacteria, including MRSA isolates resistant to linezolid. It is not inferior to linezolid in treating skin and soft tissue infections (SSTI).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

The times they are a-changin': new antibacterials for skin and skin structure infections.

Author: TranMai-Chi N, NaumovskiSnezana, GoldsteinEllie J C

MRSA treatment
skin infection treatment
side effects

This review discussed the therapeutic efficacy of five new agents for the therapy of skin and soft tissue infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Recently approved antibacterials for methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive pathogens: the shock of the new.

Author: DavidMichael Z, DrydenMatthew, GottliebThomas, TattevinPierre, GouldIan M

Antimicrobial activity

This study reviews the five most promising newly approved antimicrobial drugs with activity against Gram-positive bacterial pathogens: ceftaroline, ceftobiprole, oritavancin, dalbavancin, and tedizolid. The study discusses the advantages and disadvantages of these drugs, including their dosing regimens, mechanisms of action, and adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Pharmacokinetics, Safety and Tolerability of Single Oral or Intravenous Administration of 200 mg Tedizolid Phosphate in Adolescents.

Author: BradleyJohn S, FlanaganShawn D, ArrietaAntonio C, JacobsRichard, CapparelliEdmund, ProkocimerPhilippe

Safe and tolerable treatment

Tedizolid is a new antibacterial drug used to treat skin infections. This study assessed the pharmacokinetics, safety, and tolerability of tedizolid phosphate in adolescents after administration of a single intravenous or oral dose.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Long-term use of tedizolid for pulmonary nocardiosis.

Author: ChomeiYuri, NishimuraSho, IwataKentaro

Nocardiosis treatment

This case report describes a patient with minimal change nephrotic syndrome who developed pulmonary nocardiosis and Pneumocystis pneumonia. Tedizolid, a bacteriostatic oxazolidine antibiotic, was effectively used for long-term treatment of nocardiosis, suggesting potential as an alternative to linezolid.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Tedizolid phosphate for the management of acute bacterial skin and skin structure infections: safety summary.

Author: DasDebaditya, TulkensPaul M, MehraPurvi, FangEdward, ProkocimerPhilippe

Gram-positive infection treatment
Thrombocytopenia

Tedizolid phosphate, a new antibiotic, has demonstrated a favorable safety profile in preclinical studies and clinical trials. It is a promising treatment option for serious Gram-positive infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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