Side Effects of tetrahydrozoline ophthalmic: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Major Study Findings

Two identically designed Phase 3, randomized, double-blind clinical trials found that once-daily oral sarecycline 1.5 mg/kg/day is effective for moderate to severe acne vulgaris. 1

Reasons for Side Effects

Side effects may limit the use of current tetracycline-class antibiotics for acne. 1

Common Side Effects

Gastrointestinal

The most common side effects of sarecycline were related to the gastrointestinal system. 1

Skin

Skin side effects included rash, pruritus, and photosensitivity. 1

Other

Other side effects included headache, dizziness, and fatigue. 1

Side Effects Management

Gastrointestinal

If you experience gastrointestinal side effects, you may want to consider dietary changes or lifestyle modifications. 1

Skin

If you experience skin side effects, you should follow your doctor's instructions and receive appropriate treatment. 1

Other

If you experience other side effects, you should consult with your doctor. 1

Study Comparison

Similarities

Both studies were identically designed Phase 3, randomized, double-blind clinical trials. 1

Differences

The two studies differed in the age and gender composition of the participants. 1

Real-life Application Considerations

Sarecycline is an effective drug for the treatment of moderate to severe acne vulgaris but has the potential for side effects. 1

Current Research Limitations

These studies did not evaluate the long-term safety and efficacy of sarecycline. 1

Future Research Directions

Future studies should evaluate the long-term safety and efficacy of sarecycline. 1

Conclusion

Sarecycline is an effective drug for the treatment of moderate to severe acne vulgaris but has the potential for side effects. 1

If you are considering using sarecycline, talk to your doctor and discuss the risks and benefits of the drug. 1

Keywords
Benefit Keywords
Acne treatment
1
Risk Keywords
Side effects
1
Literature analysis of 1 papers
Positive Content
1
Neutral Content
0
Negative Content
0
Article Type
1
0
0
0
1
1.

Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials.

Author: MooreAngela, GreenLawrence J, BruceSuzanne, SadickNeil, TschenEduardo, WerschlerPhilip, Cook-BoldenFran E, DhawanSunil S, ForshaDouglass, GoldMichael H, GuenthnerScott, KempersSteven E, KircikLeon H, ParishJennifer L, RendonMarta I, RichPhoebe, Stein-GoldLinda, TyringStephen K, WeissRobert A, NasirAdnan, SchmitzCarsten, BoodhooTerry I, KaoukhovAlexandre, BerkDavid R

Acne treatment
Side effects

Sarecycline, a narrow-spectrum tetracycline antibiotic, was safe, well tolerated, and effective in patients with moderate to severe acne.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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