Side Effects of tezepelumab injection: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Major Research Findings

Two identically designed, Phase 3, randomized, double-blind clinical trials found that once-daily oral sarecycline 1.5 mg/kg/day is effective for moderate to severe acne vulgaris. 1

Reasons for Side Effects

Side effects may limit the use of current tetracycline-class antibiotics for acne. 1

Common Side Effects

Gastrointestinal

Common side effects of sarecycline include gastrointestinal issues. 1

Skin

Skin side effects include rash and itching. 1

Other

Other side effects include headache, dizziness, and fatigue. 1

Side Effect Management

Gastrointestinal

To reduce gastrointestinal side effects, sarecycline is recommended to be taken with food. 1

Skin

If you are concerned about skin side effects, talk to your doctor. 1

Other

If you experience any other side effects, talk to your doctor. 1

Comparison Between Studies

Commonalities

Both studies found that sarecycline is effective for treating moderate to severe acne vulgaris. 1

Differences

There were slight differences in the side effect profiles between the two studies. 1

Real-Life Application Considerations

Sarecycline may be a promising option for treating moderate to severe acne vulgaris. However, it is not suitable for all patients. Talk to your doctor before using sarecycline. 1

Limitations of Current Research

These studies were conducted on relatively small sample sizes. Therefore, the findings may not be applicable to everyone. 1

Future Research Directions

Further research is needed to examine the long-term efficacy and safety of sarecycline. 1

Conclusion

Sarecycline has the potential to be a promising treatment option for moderate to severe acne vulgaris. However, it is important to be aware of the potential side effects. If you are considering using sarecycline, talk to your doctor. 1

Keywords
Benefit Keywords
Acne treatment
1
Risk Keywords
Side effects
1
Literature analysis of 1 papers
Positive Content
1
Neutral Content
0
Negative Content
0
Article Type
1
0
0
0
1
1.

Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials.

Author: MooreAngela, GreenLawrence J, BruceSuzanne, SadickNeil, TschenEduardo, WerschlerPhilip, Cook-BoldenFran E, DhawanSunil S, ForshaDouglass, GoldMichael H, GuenthnerScott, KempersSteven E, KircikLeon H, ParishJennifer L, RendonMarta I, RichPhoebe, Stein-GoldLinda, TyringStephen K, WeissRobert A, NasirAdnan, SchmitzCarsten, BoodhooTerry I, KaoukhovAlexandre, BerkDavid R

Acne treatment
Side effects

Sarecycline, a narrow-spectrum tetracycline antibiotic, was safe, well tolerated, and effective in patients with moderate to severe acne.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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