Side Effects of tobramycin injection: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Major Research Findings

Two identically designed Phase 3, randomized, double-blind clinical trials have shown that once-daily oral sarecycline 1.5 mg/kg/day is effective for moderate to severe acne vulgaris. 1

Reasons for Side Effects

Side effects may limit the use of current tetracycline-class antibiotics for acne. 1

Common Side Effects

Gastrointestinal

Gastrointestinal issues are a common side effect of sarecycline. 1

Skin

Skin side effects are one of the common side effects of sarecycline. 1

Other

Other side effects of sarecycline reported include headache and dizziness. 1

Side Effects Management

Gastrointestinal

To minimize gastrointestinal side effects, sarecycline is recommended to be taken with food. 1

Skin

To reduce skin side effects, stop using sarecycline and consult your doctor. 1

Other

If you are concerned about side effects of sarecycline, talk to your doctor. 1

Comparison of Studies

Study Similarities

Both studies were identically designed Phase 3, randomized, double-blind clinical trials. Both demonstrated that once-daily oral sarecycline 1.5 mg/kg is effective for moderate to severe acne vulgaris. 1

Study Differences

The two studies differed in the age and gender composition of the participants. Additionally, the two studies had different durations of sarecycline administration. 1

Real-Life Application Notes

While sarecycline is an effective drug for treating acne vulgaris, there are risks of side effects. It is important to consult with your doctor and follow their instructions when using sarecycline. 1

Current Study Limitations

These studies did not evaluate the long-term safety and efficacy of sarecycline. Additionally, these studies did not compare sarecycline with other acne treatments. 1

Future Research Directions

Further research is needed to assess the long-term safety and efficacy of sarecycline. Comparative studies of sarecycline with other acne treatments are also needed. 1

Conclusion

Once-daily oral sarecycline 1.5 mg/kg is an effective drug for treating moderate to severe acne vulgaris. However, sarecycline carries the risk of side effects. It is important to consult with your doctor and follow their instructions when using sarecycline. 1

Keywords
Benefit Keywords
Acne treatment
1
Risk Keywords
Side effects
1
Literature analysis of 1 papers
Positive Content
1
Neutral Content
0
Negative Content
0
Article Type
1
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0
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1
1.

Once-Daily Oral Sarecycline 1.5 mg/kg/day Is Effective for Moderate to Severe Acne Vulgaris: Results from Two Identically Designed, Phase 3, Randomized, Double-Blind Clinical Trials.

Author: MooreAngela, GreenLawrence J, BruceSuzanne, SadickNeil, TschenEduardo, WerschlerPhilip, Cook-BoldenFran E, DhawanSunil S, ForshaDouglass, GoldMichael H, GuenthnerScott, KempersSteven E, KircikLeon H, ParishJennifer L, RendonMarta I, RichPhoebe, Stein-GoldLinda, TyringStephen K, WeissRobert A, NasirAdnan, SchmitzCarsten, BoodhooTerry I, KaoukhovAlexandre, BerkDavid R

Acne treatment
Side effects

Sarecycline, a narrow-spectrum tetracycline antibiotic, was safe, well tolerated, and effective in patients with moderate to severe acne.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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