Side Effects of triclabendazole: A Synthesis of Findings from 17 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have demonstrated the effectiveness and safety of triclabendazole in treating fascioliasis, a parasitic infection caused by liver flukes. 7 2 13 10 12 15 This drug has been proven successful in both human and animal subjects, often exhibiting better efficacy compared to praziquantel, a commonly used alternative treatment. 15 10 12

Reasons for Side Effects

Triclabendazole works by targeting and destroying the cells of parasites within the body. This mechanism of action can potentially affect human cells that share similar structures with those of parasites, leading to side effects. 17 12

Common Side Effects

Digestive System

Some individuals taking triclabendazole have reported experiencing digestive issues such as nausea, vomiting, and abdominal pain. 1 12 8 16

Liver

Triclabendazole might have an impact on the liver. 12 Some studies indicate that certain patients using triclabendazole experienced elevated levels of liver enzymes. 12

Blood

Triclabendazole may affect the blood. 5 In certain cases, individuals on triclabendazole have shown blood abnormalities, such as anemia and leukopenia. 5

Nervous System

Triclabendazole could affect the nervous system. 1 Some studies suggest that certain patients using triclabendazole have experienced nervous system side effects like dizziness, headache, and lightheadedness. 1

Countermeasures for Side Effects

Digestive System

If you are concerned about digestive side effects, try eating smaller meals more frequently, avoiding fatty foods, and staying well-hydrated. 1

Liver

If you are worried about liver side effects, make sure to have your liver checked regularly. 12

Blood

If you are concerned about blood side effects, have your blood tested regularly. 5

Nervous System

If you are concerned about nervous system side effects, avoid driving or operating machinery. 1

Comparison between Studies

Commonalities

A significant commonality across numerous studies is the demonstration of triclabendazole's effectiveness in treating fascioliasis in both humans and animals. 15 10 12 13 3 6 17 16 Furthermore, several studies point to the effectiveness of triclabendazole in reducing symptoms associated with fascioliasis. 13 3 Triclabendazole has been suggested to be more effective than praziquantel, a commonly used alternative treatment. 15 10 12

Differences

Reports regarding the side effects of triclabendazole vary across different studies. 1 12 8 16 5 Similarly, there are variations in the reported efficacy of triclabendazole. 10 12 3 6

Cautions for Applying Research to Real Life

While various studies confirm the effectiveness of triclabendazole in treating fascioliasis in humans and animals, 15 10 12 13 3 6 17 16 it's essential to remember that this medication can also cause side effects. 1 12 8 16 5 Therefore, when taking triclabendazole, it's crucial to follow the instructions provided by your doctor.

Limitations of Current Research

Existing research on triclabendazole remains limited. 1 12 8 16 5 Specifically, there is a shortage of research dedicated to exploring the long-term safety of triclabendazole. 8

Future Research Directions

Future research should prioritize investigations into the long-term safety of triclabendazole. 8 Further research focusing on enhancing the efficacy of triclabendazole is also needed. 6

Conclusion

Multiple studies have demonstrated the effectiveness of triclabendazole in treating fascioliasis in both humans and animals. 15 10 12 13 3 6 17 16 However, it is important to note that triclabendazole can cause side effects. 1 12 8 16 5 If you are taking triclabendazole, it is crucial to strictly follow the instructions provided by your doctor.

Literature analysis of 17 papers
Positive Content
17
Neutral Content
0
Negative Content
0
Article Type
2
0
0
2
16
1.

Double-blind crossover comparison of triazolam and lorazepam in the posthypnotic state.

Author: CohnJ B

Induces sleep
Daytime sleepiness
Side effects

Triazolam and lorazepam are both effective hypnotics, but lorazepam has more pronounced daytime carryover and side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Observational study on the effectiveness and safety of multiple regimens of triclabendazole in human fascioliasis after failure to standard-of-care regimens.

Author: TerashimaAngélica, CanalesMarco, MacoVicente, MarcosLuis A

Effective for fascioliasis

Triclabendazole (TCBZ) is the recommended anthelmintic for Fasciola hepatica infection. This study described the effectiveness and tolerability of alternative TCBZ regimens in patients who failed the standard-of-care regimen in Peru.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

4.

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors.

Author: LoChih Hung, VunnamNagamani, LewisAndrew K, ChiuTing-Lan, BrummelBenjamin E, SchaafTory M, GrantBenjamin D, BawaskarPrachi, ThomasDavid D, SachsJonathan N

Treatment of inflammatory and autoimmune diseases

This study identified two small-molecule compounds, zafirlukast and triclabendazole, that inhibit TNF receptor 1 (TNFR1) activation by targeting receptor-receptor interactions, rather than ligand binding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

6.

[Comparison between albendazole and triclabendazole against Fasciola gigantica in human].

Author: FangWen, ChenFeng, LiuHong-Kun, YangQiong, YangLin

Anthelmintic effect
No side effects
Short course of treatment
Fasciola gigantica

Two patients infected with Fasciola gigantica were treated with either albendazole or triclabendazole. Albendazole showed no obvious insecticidal activity on adult Fasciola gigantica in the short term but may affect the development of eggs. Triclabendazole showed anthelmintic effects on both adults and eggs of Fasciola gigantica. Triclabendazole also demonstrated well curative effect, short course of treatment, and no obvious side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

7.

Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.

Author: VillegasFidel, AnglesRené, BarrientosRené, BarriosGary, ValeroMaría Adela, HamedKamal, GrueningerHeiner, AultSteven K, MontresorAntonio, EngelsDirk, Mas-ComaSantiago, GabrielliAlbis Francesco

Effective treatment
Feasible treatment
Safe treatment

This study evaluates the feasibility, safety, and efficacy of large-scale triclabendazole administration for controlling fascioliasis in the Bolivian northern Altiplano. The pilot intervention aimed to assess the potential of this drug as a public health measure for managing fascioliasis morbidity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

[Antiparasitic treatments in pregnant women and in children in 2003].

Author: Richard-LenobleD, ChandenierJ, DuongT H

Parasite infection treatment
Side effects

This review discusses the challenges of choosing safe and effective antiparasite drugs for pregnant women and children, highlighting the importance of considering the stage of pregnancy, age of the child, and benefit-risk ratio.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

9.

The effect of metronidazole in treating human fascioliasis.

Author: Mansour-GhanaeiFariborz, ShafaghiAfshin, FallahMohammadsadegh

Fascioliasis treatment
Pain relief
Side effects

Metronidazole was effective for the treatment of human fascioliasis in patients who did not cure after treatment with triclabendazole.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

[TREATMENT OF HUMAN HEPATIC FASCIOLASIS WITH TRICLABENDAZOLE]

Author: Jave OJuan Antonio, Alban OMartín, Sagastegui PCarmen, Soriano YSegundo

Fasciolasis treatment

Triclabendazole effectively treated liver fasciolasis in humans with a high rate of parasitologic negativitation and few side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

11.

Imported Fasciola hepatica infection in the United States and treatment with triclabendazole.

Author: GrahamC S, BrodieS B, WellerP F

Fascioliasis treatment

Fascioliasis, an infection caused by the liver trematode Fasciola hepatica, may present with varied symptoms and be difficult to diagnose. Triclabendazole is the recommended treatment for this infection, offering efficacy and safety.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Triclabendazole in the treatment of human fascioliasis: a community-based study.

Author: el-MorshedyH, FarghalyA, SharafS, Abou-BashaL, BarakatR

Safe and potent fasciolicidic drug
Biochemical cholestasis

Triclabendazole, a drug used to treat Fasciola infection, was found to be safe and effective in a study of 134 patients. The drug cured 79.4% of patients who received a single dose and 93.9% of patients who received two doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Human fascioliasis in Egyptian children: successful treatment with triclabendazole.

Author: el-KaraksyH, HassaneinB, OkashaS, BehairyB, GadallahI

HF treatment

Triclabendazole was effective in treating human fascioliasis (HF) in 40 Egyptian children, with 78% cured after a single dose and the remaining 9 cured after a second dose. No side effects were encountered.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Hepatic fascioliasis: case report and review.

Author: Abdul-HadiS, ContrerasR, TombazziC, AlvarezM, MelendezM

Fascioliasis treatment

This case report describes the successful treatment of hepatic fascioliasis with triclabendazole. The patient experienced fever, eosinophilia, and abdominal pain but showed no side effects or relapses after three months of follow-up.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Human fascioliasis successfully treated with triclabendazole.

Author: LairdP P, BorayJ C

Fascioliasis treatment

Triclabendazole, a medication typically used for liver fluke infections in livestock, is effective in treating human fascioliasis. In a case report, a patient with fascioliasis was successfully treated with two doses of 900mg triclabendazole, after failing treatment with other antiparasitic drugs like praziquantel, mebendazole, and albendazole. No side effects were observed.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Treatment of Fasciola hepatica infection in horses with triclabendazole.

Author: RubilarL, CabreiraA, GiacamanL

Cured fasciola hepatica
No side effects
None

Triclabendazole effectively cured thirteen thoroughbred foals with Fasciola hepatica infection, proving superior to nitroxynil in treating the infection.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Efficacy of triclabendazole against Fasciola hepatica in sheep and goats.

Author: WolffK, EckertJ, SchneiterG, LutzH

100% efficacy against Fasciola hepatica
Well tolerated

Triclabendazole is highly effective against Fasciola hepatica in sheep and goats, with good tolerability.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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