Side Effects of umeclidinium and vilanterol oral inhalation: A Synthesis of Findings from 1 Studies

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Original Abstract of the Article

Major Research Findings

This study found that vitamin E (800 IU/day) did not improve the incidence, severity, or duration of side effects associated with isotretinoin (1 mg/kg per day) in patients with severe acne vulgaris. 1

Reasons for Side Effects

Isotretinoin, a retinoid, works by regulating skin cell growth and reducing sebum production, which helps control acne. However, these effects can also lead to side effects like dry eyes, dry lips, and skin dryness. 1

Common Side Effects

Dry eyes

Isotretinoin can cause dry eyes by reducing the oil production on the surface of the eyes. 1

Dry lips

Isotretinoin can cause dry lips by reducing moisture levels in the lips. 1

Side Effects Management

Dry eyes

If you experience dry eyes, using eye drops to keep your eyes lubricated can help. 1

Dry lips

If you experience dry lips, applying lip balm can help keep your lips moisturized. 1

Research Comparisons

Research Similarities

Several studies have reported dry eyes, dry lips, and skin dryness as common side effects of isotretinoin. 1

Research Differences

Variations in the incidence and severity of side effects associated with isotretinoin may occur across studies due to factors such as patient age, sex, isotretinoin dosage, and other variables. 1

Practical Implications

It is essential to follow your doctor's instructions carefully and take isotretinoin only as prescribed. If you experience any side effects, consult your doctor immediately. 1

Limitations of the Study

This study focused on the effect of vitamin E on isotretinoin side effects, and other potential side effect mitigation strategies were not investigated. 1

Future Research Directions

More effective methods to manage isotretinoin side effects warrant further investigation. Additionally, a deeper understanding of the specific side effects that can occur with isotretinoin, their probability, and their benefits compared to risks is needed. 1

Conclusion

This research demonstrated that vitamin E did not significantly improve side effects associated with isotretinoin (1 mg/kg) for severe acne. When taking isotretinoin, it is crucial to understand the risks and benefits, discuss treatment options with your doctor, and seek medical attention if any side effects arise. 1

Keywords
Benefit Keywords
Risk Keywords
No improvement in retinoid side effects
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Literature analysis of 1 papers
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Article Type
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Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial.

Author: StraussJ S, GottliebA B, JonesT, KooJ Y, LeydenJ J, LuckyA, PappasA A, McLaneJ, LeachE E

No improvement in retinoid side effects

Vitamin E did not significantly ameliorate retinoid side effects when combined with isotretinoin in the treatment of acne.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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