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Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial.

Author: GottliebA B, JonesT, KooJ Y, LeachE E, LeydenJ J, LuckyA, McLaneJ, PappasA A, StraussJ S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Vitamin E did not significantly ameliorate retinoid side effects when combined with isotretinoin in the treatment of acne.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Isotretinoin treatment is frequently associated with reversible, dose-related side effects. Recent studies claimed that combining vitamin E with high-dose isotretinoin ameliorated isotretinoin-induced side effects. OBJECTIVE: The purpose of this double-blind, randomized study was to det...See full text at original site
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引用元：
https://doi.org/10.1067/mjd.2000.110391

データ提供：米国国立医学図書館（NLM）

The Effect of Vitamin E on Isotretinoin Side Effects

The realm of dermatology is constantly searching for effective treatments for acne vulgaris, a common skin condition that affects many individuals. Isotretinoin, a powerful medication known for its effectiveness in treating severe acne, often comes with side effects such as dry eyes and lips. This research, conducted in the realm of dermatology, delves into the potential benefits of vitamin E as a companion to isotretinoin therapy. The study, a double-blind randomized trial, aimed to determine whether vitamin E could mitigate the side effects associated with isotretinoin.

Vitamin E's Impact on Isotretinoin Side Effects

The researchers discovered that combining vitamin E with isotretinoin did not result in any significant improvement in the incidence, severity, or duration of the side effects associated with isotretinoin. This finding suggests that vitamin E does not offer any noticeable benefits in reducing the side effects of isotretinoin therapy.

The Importance of Understanding Acne Treatment

While this study did not uncover a beneficial effect of vitamin E on isotretinoin side effects, it highlights the importance of continued research to find ways to improve the tolerability of acne treatments. It's crucial to consult with a dermatologist to discuss potential side effects and develop an effective acne treatment plan that minimizes discomfort.

Dr.Camel's Conclusion

It's a bit like a camel searching for a cool oasis in the desert. Sometimes, what we think might be a solution doesn't quite quench our thirst. While vitamin E didn't offer a solution to the side effects of isotretinoin, it reminds us that the journey to find solutions for acne is ongoing, and we must continue to explore different possibilities.

Date :
  1. Date Completed 2001-04-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11050580

DOI: Digital Object Identifier

10.1067/mjd.2000.110391

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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