Side Effects of venlafaxine: A Synthesis of Findings from 23 Studies

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This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Research Findings

Venlafaxine is a selective serotonin and norepinephrine reuptake inhibitor (SSRI) used to treat depression and anxiety. Although venlafaxine is an effective medication, it can cause some side effects. Recent studies have shown that venlafaxine may cause weight gain, sexual side effects, digestive side effects, metabolic side effects, heart side effects, and neurological side effects. Also, venlafaxine can interact with other medications and cause serious side effects.

Reasons for side effects

Venlafaxine's side effects are caused by its inhibition of serotonin and norepinephrine reuptake. Serotonin and norepinephrine are neurotransmitters involved in mood, sleep, appetite, and sex drive. Venlafaxine increases the levels of these neurotransmitters, which can cause side effects by disrupting the balance of these neurotransmitters.

Common side effects

Weight gain

Venlafaxine can cause an increase in appetite and a decrease in metabolism, which can lead to weight gain. 17 , 5

Sexual side effects

Venlafaxine can cause sexual side effects such as decreased libido, erectile dysfunction, and ejaculatory disorders. 12 , 5

Digestive side effects

Venlafaxine can cause digestive side effects such as nausea, vomiting, constipation, and diarrhea. 17

Metabolic side effects

Venlafaxine can cause metabolic side effects such as increased blood sugar and cholesterol. 16

Heart side effects

Venlafaxine can cause heart side effects such as increased heart rate and blood pressure. 13 , 21 , 2

Neurological side effects

Venlafaxine can cause neurological side effects such as dizziness, headache, drowsiness, insomnia, and tremors. 3 , 1

Side effects management

Weight gain

To prevent weight gain, it is important to maintain a healthy diet and exercise regularly. You can also talk to your doctor about getting advice on weight management.

Sexual side effects

If you experience sexual side effects, talk to your doctor about switching to a different medication or adjusting the dose of venlafaxine.

Digestive side effects

If you experience digestive side effects, you can consider dietary changes or medication. Talk to your doctor to find the right solution for you.

Metabolic side effects

If you experience metabolic side effects, talk to your doctor about getting advice on managing blood sugar and cholesterol levels.

Heart side effects

If you experience heart side effects, talk to your doctor immediately.

Neurological side effects

If you experience neurological side effects, talk to your doctor to find the right solution for you.

Comparison between studies

Commonalities of studies

Multiple studies have shown that venlafaxine can cause side effects such as weight gain, sexual side effects, and digestive side effects. These side effects are caused by venlafaxine inhibiting the reuptake of serotonin and norepinephrine.

Differences in studies

Each study had different frequencies and severities of side effects. This is likely due to a variety of factors, such as the age, gender, health status, and other medications taken by the study participants. Differences in research methods may also have contributed.

Points to note regarding application to real life

It's important to understand the risks of side effects when taking venlafaxine. If you experience any side effects, talk to your doctor right away. Before taking venlafaxine, talk to your doctor to check for potential interactions with other medications.

Limitations of current research

There is still not enough research on the side effects of venlafaxine. More research is needed on long-term side effects and side effects in specific populations, especially children and adolescents.

Future research directions

Further research on the side effects of venlafaxine should focus on the following: * Long-term side effects * Side effects in specific populations * Mechanisms of side effects * Prevention and treatment of side effects

Conclusion

Venlafaxine is an effective medication for treating depression and anxiety, but it can cause some side effects. If you are taking venlafaxine, be aware of the risks of side effects and talk to your doctor immediately if you experience any. More research is needed on the side effects of venlafaxine.

Literature analysis of 23 papers
Positive Content
13
Neutral Content
2
Negative Content
7
Article Type
2
3
1
3
20
1.

Serotonin Syndrome: An Emerging Reality in the Emergency Department.

Author: MonteiroMarta, PinheiroNuno C, SamjiVikesh

SS treatment
SS morbidity
SS mortality

This case report describes a patient who developed serotonin syndrome (SS) after ingesting multiple tablets of escitalopram and venlafaxine, emphasizing the importance of clinical awareness of SS and timely treatment.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

3.

A comprehensive review and meta-analysis of neurological side effects related to second-generation antidepressants in individuals with major depressive disorder.

Author: ZhouQi, LiXinming, YangDejiang, XiongChongyu, XiongZhenrong

Depression treatment
Neurological side effects

This meta-analysis found that most second-generation antidepressants increase the risk of neurological side effects compared to placebo. Agomelatine, bupropion, and vortioxetine showed a reduced risk of specific neurological side effects.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Early intervention of acute liver injury related to venlafaxine: A case report.

Author: FangLin, WangShushan, CaoLeiming, YaoKun

Liver injury

This report presents a case of drug-induced liver injury (DILI) after venlafaxine, an antidepressant, administration.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

A case of venlafaxine-induced angioedema in an older adult.

Author: GriffinHailee, PearsonScott, LinneburSunny, FixenDanielle

Angioedema treatment
Angioedema
Antidepressant side effects

This case report describes a patient who experienced angioedema after taking venlafaxine.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

8.

Antidepressant side effects and their impact on treatment outcome in people with major depressive disorder: an iSPOT-D report.

Author: BraundTaylor A, TillmanGabriel, PalmerDonna M, GordonEvian, RushA John, HarrisAnthony W F

Depression treatment
Side effects
Treatment outcome

This study looks at the frequency, intensity, and burden of side effects associated with antidepressant medications in people with major depressive disorder (MDD). The study found that the burden of side effects was associated with poorer treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Leveraging digital media data for pharmacovigilance.

Author: FarooqHammad, NiazJunaid Suhail, FakharSaira, NaveedHammad

Under-reported side effects

This study explored the potential of using digital media to discover under-reported side effects of marketed drugs. By analyzing tweets related to 11 different drugs, the researchers found a high concordance between Twitter data and known adverse drug reactions reported in the FAERS database. They also identified several under-reported side effects that were not reported in FAERS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Clinical implementation of preemptive pharmacogenomics in psychiatry: Τhe "PREPARE" study.

Author: TsermpiniE E, SkokouM, FerentinosP, GeorgilaE, GourzisP, AssimakopoulosK, PatrinosG P,

PREPARE, the first prospective pharmacogenomics study in Europe, aims to reduce the occurrence and severity of drug-genotype-associated adverse drug reactions (ADRs) in psychiatric patients. The study will recruit 1500 patients who will receive either standard or pharmacogenomic-guided treatment for depression or psychosis. The study aims to demonstrate that pharmacogenomic-guided treatment can reduce ADRs by 30% compared to standard care.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Modafinil Induced Spontaneous Ejaculation Without Orgasm: A Case Report.

Author: ArasNeriman

Erectile dysfunction treatment
Premature ejaculation treatment
Sleep apnea treatment
Hypersexuality
Unwanted orgasm

Modafinil, a drug used for the treatment of narcolepsy and obstructive sleep apnea syndrome, has been reported to cause unwanted sexual side effects, such as spontaneous ejaculation, in some patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

The Cardiovascular Effects of Newer Antidepressants in Older Adults and Those With or At High Risk for Cardiovascular Diseases.

Author: BehlkeLauren M, LenzeEric J, CarneyRobert M

Depression treatment
Cardiovascular side effects

Depression is a common mental health condition that can affect people of all ages, including older adults. While selective serotonin reuptake inhibitors (SSRIs) are often the first-line treatment for depression, many patients do not respond to these medications. This review summarizes what is known about the cardiovascular side effects of some of the newer antidepressants, including venlafaxine, desvenlafaxine, duloxetine, milnacipran, levomilnacipran, mirtazapine, bupropion, vilazodone, vortioxetine, agomelatine, moclobemide, and ketamine-esketamine. While some of these drugs may be safe and effective alternatives for older adults and patients with cardiovascular disease, more research is needed to fully understand their safety and efficacy in these patient populations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Comparative efficacy of placebos in short-term antidepressant trials for major depression: a secondary meta-analysis of placebo-controlled trials.

Author: HolperLisa, HengartnerMichael P

Unblinding bias

The study explores the unblinding bias in antidepressant trials due to drug side effects, and how this can lead to placebo ratings being less effective for the drug in question compared to other antidepressants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Desvenlafaxine-associated hyperglycemia: A case report and literature review.

Author: MekonnenAndrea D, MillsAubrey A, WilhiteAndrea L, HoffmanTheresa K

Anxiety treatment
Depression treatment
Hyperglycemia

Desvenlafaxine, an antidepressant, may cause hyperglycemia in some patients with diabetes. This case report describes a patient who experienced increased blood sugar levels after starting desvenlafaxine, highlighting the need to monitor blood sugar levels carefully in patients taking this medication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

18.

Serotonin-norepinephrine reuptake inhibitors for the prevention of migraine and vestibular migraine: a systematic review and meta-analysis.

Author: WangFengzhi, WangJiaoqi, CaoYumeng, XuZhongxin

Migraine prevention

This review focused on the efficacy and tolerability of serotonin-norepinephrine reuptake inhibitors (SNRIs) for migraine and vestibular migraine prevention. The role of SNRIs in migraine prophylaxis has not been fully established, and current treatments for vestibular migraine are based on limited evidence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

The Risk of QTc-Interval Prolongation in Breast Cancer Patients Treated with Tamoxifen in Combination with Serotonin Reuptake Inhibitors.

Author: HussaartsKoen G A M, BergerFlorine A, BinkhorstLisette, Oomen-de HoopEsther, van LeeuwenRoelof W F, van AlphenRobbert J, Mathijssen-van SteinDaniëlle, de GrootNatasja M S, MathijssenRon H J, van GelderTeun

Cardiac side effects
QTc prolongation

This study investigates whether there is a drug-drug interaction between tamoxifen and SRIs resulting in a prolonged QTc-interval.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis.

Author: TomlinsonAnneka, EfthimiouOrestis, BoadenKatharine, NewEmma, MatherSarah, SalantiGeorgia, ImaiHissei, OgawaYusuke, TajikaAran, KishimotoSanae, KikuchiSino, ChevanceAstrid, FurukawaToshi A, CiprianiAndrea

Major depression treatment
Adverse events

This study presents a protocol for a network meta-analysis comparing the efficacy, adverse events, and tolerability of all second-generation and selected first-generation antidepressants in the acute treatment of major depression in adults. The study aims to extend previous findings and update the evidence base for antidepressant treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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