Effective treatment of vitiligo: A Synthesis of Findings from 77 Studies

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Original Abstract of the Article

Major Research Findings

Various methods have been tried to treat vitiligo. Previous studies have reported that laser therapy, phototherapy, drug therapy, surgery, and other therapies have shown efficacy. 70 shows that excimer laser is effective in vitiligo treatment, induces repigmentation rates comparable to NB-UVB and has improved outcomes when combined with calcineurin inhibitors. Ablative lasers are commonly used for tissue graft or melanocyte-keratinocyte cell graft transplantation. They provide safe, fast and uniform denudation of the epidermis with propitious repigmentation outcomes. 53 reports that JAK1/3 inhibitors such as tofacitinib and ruxolitinib have shown promising results in vitiligo treatment. These drugs are expected to have the effect of suppressing the destruction of melanocytes and promoting repigmentation. 58 shows that VITILSI-gel and NB-UVB combination therapy is effective in vitiligo treatment. VITILSI-gel is expected to promote the proliferation of melanocytes and promote repigmentation. 65 suggests that adding topical calcipotriol to phototherapy may enhance the efficacy of treatment in patients with vitiligo. Calcipotriol is a vitamin D3 analog and is expected to have the effect of promoting melanocyte proliferation.

Treatment Summary

70 introduces excimer laser therapy, ablative laser-based tissue grafting and melanocyte-keratinocyte cell grafting. 53 introduces JAK1/3 inhibitors such as tofacitinib and ruxolitinib. 58 introduces VITILSI-gel and NB-UVB combination therapy. 65 introduces therapy combining calcipotriol with phototherapy.

Benefits and Risks

Benefits Summary

Research has shown that vitiligo treatment promotes repigmentation and helps improve patients' quality of life. Another major benefit is that a variety of treatment methods are being developed, increasing treatment options.

Risks Summary

Vitiligo treatment has the risk of side effects. For example, laser therapy may cause side effects such as skin inflammation and pigmentation. Drug therapy may also cause side effects such as liver dysfunction and immunosuppression. It is important to understand these risks before undergoing treatment.

Comparison Between Studies

Commonalities Between Studies

Many studies have shown that vitiligo treatment promotes repigmentation and helps improve patients' quality of life. Moreover, it has been shown that various treatment methods are effective.

Differences Between Studies

The effective treatment methods and side effect risks may differ depending on the study. For example, 70 reports that excimer laser shows repigmentation rates comparable to NB-UVB, while 53 reports that JAK1/3 inhibitors have shown promising results in vitiligo treatment. As such, effective treatment methods and side effect risks may differ depending on the study. Therefore, it is important to consult with your doctor before undergoing treatment.

Consistency and Discrepancies in Results

There are inconsistencies and discrepancies in the results of studies on vitiligo treatment. For example, 70 reports that excimer laser shows repigmentation rates comparable to NB-UVB, while other studies report that excimer laser is superior to NB-UVB. As such, there are inconsistencies in the research results, and further research is necessary.

Points to Note When Applying the Results to Real Life

The optimal treatment for vitiligo varies depending on the patient's condition and medical history. Therefore, it is important to consult with your doctor before undergoing treatment. Treatment can also take time, and you may not see results immediately. It is important to continue treatment persistently.

Limitations of Current Research

Research on vitiligo treatment is still developing. For example, research on treatment effectiveness evaluation methods and side effect risks is lacking. Moreover, research on long-term treatment effects and recurrence rates after treatment is also lacking. Further research is expected to make vitiligo treatment safer and more effective.

Future Research Directions

Future research on vitiligo treatment should focus on developing more effective and safe treatment methods, long-term evaluation of treatment effectiveness, and suppression of recurrence rates after treatment. Basic research, such as elucidating the causes of vitiligo and its pathogenesis, is also important.

Conclusion

A variety of treatment methods are being developed for vitiligo treatment, increasing treatment options. However, research on treatment effectiveness and side effect risks is still insufficient. Future research is expected to make vitiligo treatment safer and more effective.

If you are concerned about vitiligo, consult a doctor instead of struggling alone.

List of Treatments

Excimer laser therapy, Ablative laser therapy, Tissue graft, Melanocyte-keratinocyte cell graft, JAK1/3 inhibitors, VITILSI-gel, NB-UVB, Calcipotriol, Phototherapy

Keywords
Benefit Keywords
Vitiligo repigmentation
1
Improved vitiligo treatment
2
Improved vitiligo response
3
Repigmentation
4
Improved quality of life
5
Repigmentation
6
Repigmentation
7
Repigmentation
Vitiligo treatment
8
Improved vitiligo treatment
9
Improved vitiligo treatment
10
Treat vitiligo
11
Improved vitiligo treatment
12
Vitiligo treatment
13
Ginkgo biloba efficacy
L-phenylalanine efficacy
14
Vitiligo treatment
15
Improved vitiligo symptoms
16
Improved vitiligo treatment
17
Facial vitiligo treatment
Repigmentation
18
Vitiligo treatment
19
Improved quality of life
Repigmentation
20
Vitiligo treatment
21
Vitiligo treatment
22
Reduced disease impact
Vitiligo improvement
23
Repigmentation rate improvement
24
Safe treatment
Vitiligo improvement
25
Effective treatment
Enhanced clinical response
Well tolerated
26
Repigmentation
27
Vitiligo treatment
28
Effective for vitiligo
29
Equivalent efficacy
Tolerable side effects
30
CO2 laser + 5FU vitiligo
31
Vitiligo treatment
32
Vitiligo treatment
33
Topical Tacrolimus
34
Vitiligo treatment
35
Combined treatment for vitiligo
36
Arrest disease progression
37
Repigmentation of vitiligo
38
Safe
Vitiligo improvement
39
Treatment for vitiligo
40
Improved repigmentation
41
Increased repigmentation
Similar outcomes
42
Disease control
Partial repigmentation
Promising therapies
43
Repigmentation of vitiligo
44
Vitiligo treatment
45
Repigmentation
46
Vitiligo treatment
47
Improved repigmentation
Reduced vitiligo severity
48
Improved repigmentation
Safe treatment
49
Improved repigmentation
50
Improved excimer laser impact
Vitiligo repigmentation
51
Vitiligo treatment
52
Vitiligo treatment
53
Vitiligo treatment
54
Reduced vitiligo hyperpigmentation
55
Vitiligo treatment
56
NB-UVB + TCS effective
57
VITILSI- gel and UVB microphototherapy for vitiligo
58
Improved repigmentation
Vitiligo treatment
59
Repigmentation
60
Repigmentation
61
Repigmentation
62
OMP therapy
Vitiligo treatment
63
Dermabrasion
Dinoprostone
Vitiligo treatment
64
Vitiligo treatment
65
NB-UVB for vitiligo
66
Safe vitiligo treatment
67
Vitiligo treatment
68
Vitiligo treatment
69
Improved vitiligo repigmentation
70
Improved vitiligo
71
Vitiligo treatment
72
Vitiligo treatment
73
Improved vitiligo
Well tolerated
74
Vitiligo treatment
75
Flare prevention
Vitiligo treatment
76
Vitiligo treatment
77
Risk Keywords
Transient hyperpigmentation
3
Atrophy
Burning sensations
7
Vitiligo
9
Vitiligo
10
Vitiligo
12
Poor methodological quality
Reporting flaws
14
Vitiligo
17
Lack of long-term benefits
Topical preparations
20
Delayed healing
Hypertrophic scars
Pain
24
No significant adverse events
25
None mentioned
26
Transient side effects
Unsatisfactory repigmentation
27
Skin darkening
28
Need for more research
30
CO2 laser + 5FU side effects
31
Vitiligo
34
Mild adverse effects
38
Unclear which treatment is most effective
43
Isomorphic response
Scarring
48
Few side effects
51
Variable results
52
Vitiligo treatment success low
57
Short-term follow-up
59
Weight gain
63
Minor side effects
65
Skin cancer risk
67
Erythema
Hyperpigmentation
Infection
Pain
Scarring
68
Expensive
Limited body surface area
70
Pain
71
Literature analysis of 77 papers
Positive Content
74
Neutral Content
3
Negative Content
0
Article Type
58
13
17
10
77
1.

Safety and therapeutic effectiveness of 8-methoxypsoralen, 4,5',8-trimethylpsoralen, and psoralen in vitiligo.

Author: PathakM A, MosherD B, FitzpatrickT B

Vitiligo repigmentation

In a double-blind study of 366 East Indian patients with vitiligo, treatment with 8-methoxypsoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP), or psoralen and sunlight for 2-3 years resulted in full repigmentation of the face in 45% of patients receiving a combination of 8-MOP and TMP or low-dose 8-MOP. Nearly 60% of patients achieved 75-100% repigmentation of the head and neck. The chest, abdomen, and back showed good repigmentation, while the arms and legs showed less improvement. Higher doses of TMP and psoralen resulted in better repigmentation than lower doses, but not as good as 8-MOP or the combination group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

Combination of PUVAsol and topical calcipotriol in vitiligo.

Author: ParsadD, SainiR, VermaN

Improved vitiligo treatment

While many treatments exist for vitiligo, psoralens remain a common option despite inconsistent effectiveness. Recent research has linked vitiligo to disrupted calcium levels in the skin and found that melanocytes (pigment-producing cells) have receptors for vitamin D3. This suggests that vitamin D3 might play a role in vitiligo treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Combined excimer laser and topical tacrolimus for the treatment of vitiligo: a pilot study.

Author: KawalekAdam Z, SpencerJames M, PhelpsRobert G

Improved vitiligo response
Transient hyperpigmentation

Combining excimer laser treatment with topical tacrolimus accelerated repigmentation in patients with vitiligo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Optimal weekly frequency of 308-nm excimer laser treatment in vitiligo patients.

Author: HoferA, HassanA S, LegatF J, KerlH, WolfP

Repigmentation

308-nm excimer laser therapy is effective for treating vitiligo, with repigmentation occurring fastest with three times weekly treatment. However, the ultimate repigmentation initiation seems to depend on the total number of treatments, not their frequency.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A randomized placebo-controlled double-blind study of levamisole in the treatment of limited and slowly spreading vitiligo.

Author: AgarwalS, RamamM, SharmaV K, KhandpurS, PalH, PandeyR M

Improved quality of life

Levamisole is not as effective in arresting disease progression as was observed in a previous open study. A study with a larger sample size is necessary to determine if levamisole is truly superior to placebo in this respect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Tacalcitol and narrow-band phototherapy in patients with vitiligo.

Author: LeoneG, PacificoA, IacovelliP, Paro VidolinA, PicardoM

Repigmentation

Application of tacalcitol ointment in combination with twice-weekly NB-UVB phototherapy is an effective alternative treatment for patients with generalized vitiligo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Effect of topical calcipotriol, betamethasone dipropionate and their combination in the treatment of localized vitiligo.

Author: KumaranM S, KaurI, KumarB

Repigmentation
Atrophy
Burning sensations

Combined therapy with calcipotriol and betamethasone appeared to give a significantly faster onset of repigmentation along with better stability of the achieved pigmentation and fewer side effects compared to either treatment alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

[Antioxidants in vitiligo treatment].

Author: TsiskarishviliN V, TsiskarishviliTs I

Repigmentation
Vitiligo treatment

This study explored the use of Vitix, a preparation containing antioxidants, superoxide dismutase, and catalase, in treating vitiligo. The study observed repigmentation of affected areas and good tolerance, suggesting its potential as a treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

9.

The efficacy of combined PUVA and low-dose azathioprine for early and enhanced repigmentation in vitiligo patients.

Author: RadmaneshMohammed, SaediKourosh

Improved vitiligo treatment
Vitiligo

Immunosuppressant medications are commonly used to treat vitiligo. Corticosteroids are often used alone or in combination with other treatments. Cyclophosphamide and cyclosporine-A have also been used with varying success. Azathioprine might be effective for vitiligo either alone or with other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Combination of 308-nm xenon chloride excimer laser and topical calcipotriol in vitiligo.

Author: GoldingerS M, DummerR, SchmidP, BurgG, SeifertB, LäuchliS

Improved vitiligo treatment
Vitiligo

Treating vitiligo, a condition causing loss of skin color, remains difficult despite various treatment options. New therapies using specific wavelengths of light, like narrowband UVB and excimer laser, have been found to be effective and safe for both children and adults with vitiligo. Some reports suggest that combining this light therapy with calcipotriol cream may improve results.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Comparison of systemic PUVA and NB-UVB in the treatment of vitiligo: an open prospective study.

Author: BhatnagarA, KanwarA J, ParsadD, DeD

Treat vitiligo

This study compares systemic psoralen and ultraviolet A (PUVA) to narrow-band ultraviolet B (NB-UVB) in treating vitiligo, a common pigmentary disorder, noting that while retrospective studies have been published, a prospective study is needed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Current state of vitiligo therapy--evidence-based analysis of the literature.

Author: ForschnerTobias, BuchholtzStefan, StockflethEggert

Improved vitiligo treatment
Vitiligo

Vitiligo, a skin condition causing loss of pigmentation, affects 0.5-4% of people worldwide. Treatments include light therapy, steroids, and pseudocatalase. Newer options include topical immune-modulating medications, vitamin D analogs, excimer laser, and surgery/transplantation. This analysis compares these treatments and the evidence for their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled study.

Author: Middelkamp-HupM A, BosJ D, Rius-DiazF, GonzalezS, WesterhofW

Vitiligo treatment

There is a clear trend towards an increase in repigmentation of vitiligo vulgaris affecting the head and neck area when NB-UVB phototherapy is combined with oral P. leucotomos. This effect may be more pronounced in light skin types.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

A systematic review of natural health product treatment for vitiligo.

Author: SzczurkoOrest, BoonHeather S

Ginkgo biloba efficacy
L-phenylalanine efficacy
Poor methodological quality
Reporting flaws

L-phenylalanine used with phototherapy, and oral Ginkgo biloba as monotherapy show promise for the treatment of vitiligo and warrant further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Randomized controlled trial comparing the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck.

Author: SassiF, CazzanigaS, TessariG, ChatenoudL, ReseghettiA, MarchesiL, GirolomoniG, NaldiL

Vitiligo treatment

Recalcitrant vitiligo of the face and neck may benefit from the combination of excimer laser phototherapy with topical hydrocortisone 17-butyrate cream.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo.

Author: RathNamita, KarH K, SabhnaniSunil

Improved vitiligo symptoms

Narrow band UVB phototherapy was more effective than broad band UVB for treating vitiligo, and comparable to PUVA therapy. Oral minipulse steroid therapy had limited efficacy on its own.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Randomized, double-blind clinical trial to evaluate the efficacy of topical tacalcitol and sunlight exposure in the treatment of adult nonsegmental vitiligo.

Author: Rodríguez-MartínM, García BustínduyM, Sáez RodríguezM, Noda CabreraA

Improved vitiligo treatment
Vitiligo

Vitiligo, a common skin condition, is difficult to treat, and half of people develop it before age 20. It can be stigmatizing, but there is no ideal treatment that addresses the cause. Tacalcitol and other vitamin D analogs have shown the ability to stimulate both the immune system and pigment-producing cells in the skin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Response of vitiligo to once- vs. twice-daily topical tacrolimus: a controlled prospective, randomized, observer-blinded trial.

Author: RadakovicS, Breier-MalyJ, KonschitzkyR, KittlerH, SatorP, HoenigsmannH, TanewA

Facial vitiligo treatment
Repigmentation

Tacrolimus ointment is an effective treatment option for facial vitiligo, with twice-daily application achieving better repigmentation than once-daily. A guarded prognosis is advisable for lesions on other localizations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

An open randomized study to compare narrow band UVB, topical pimecrolimus and topical tacrolimus in the treatment of vitiligo.

Author: StincoGiuseppe, PiccirilloFabio, ForcioneMarina, ValentFrancesca, PatronePasquale

Vitiligo treatment

Vitiligo, a skin condition that causes loss of pigment, is difficult to treat. This study compared narrowband UVB light therapy, topical pimecrolimus cream, and topical tacrolimus ointment for vitiligo. All three treatments showed some improvement, with the best results for facial lesions with pimecrolimus or tacrolimus and for neck lesions with UVB. While all treatments are considered good options, UVB light therapy might be best for generalized vitiligo, and topical medications might be better for localized vitiligo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Interventions for vitiligo.

Author: WhittonMaxine E, PinartMariona, BatchelorJonathan, LusheyClare, Leonardi-BeeJo, GonzálezUrbà

Improved quality of life
Repigmentation
Lack of long-term benefits
Topical preparations

This review has found some evidence from individual studies to support existing therapies for vitiligo, but the usefulness of the findings is limited by the different designs and outcome measurements and lack of quality of life measures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Autologous noncultured melanocyte transplantation for stable vitiligo: can suspending autologous melanocytes in the patients' own serum improve repigmentation and patient satisfaction?

Author: SahniKanika, ParsadDavinder, KanwarAmrinderjit J, MehtaSwami Dass

Vitiligo treatment

Vitiligo, a condition causing loss of skin color, can be treated with medical and surgical methods. A new surgical approach involves transplanting a patient's own melanocytes (skin pigment cells) without culturing them in the lab. This method has shown to be effective in treating stable vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Original article title: "Comparison of therapeutic efficacy of topical corticosteroid and oral zinc sulfate-topical corticosteroid combination in the treatment of vitiligo patients: a clinical trial".

Author: YaghoobiReza, OmidianMohammad, BagheraniNooshin

Vitiligo treatment

Vitiligo, a skin condition where patches lose pigment, affects 0.1-4% of people worldwide. Understanding how vitiligo develops could lead to new treatments and ways to prevent it. This study aimed to investigate the effectiveness of zinc supplements in treating vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Effect of a preceding laser dermabrasion on the outcome of combined therapy with narrowband ultraviolet B and potent topical steroids for treating nonsegmental vitiligo in resistant localizations.

Author: BayoumiW, FontasE, SillardL, Le DuffF, OrtonneJ-P, BahadoranP, LacourJ-P, PasseronT

Repigmentation rate improvement
Delayed healing
Hypertrophic scars
Pain

Laser dermabrasion significantly improved the repigmentation rate in vitiligo lesions compared to topical steroids and UVB treatment. However, the high rate of side effects and poor tolerance limit its use in current practice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Combination treatment by 10 600 nm ablative fractional carbon dioxide laser and narrowband ultraviolet B in refractory nonsegmental vitiligo: a prospective, randomized half-body comparative study.

Author: ShinJ, LeeJ S, HannS-K, OhS H

Safe treatment
Vitiligo improvement
No significant adverse events

Fractional CO(2) laser therapy followed by NB-UVB phototherapy could be used effectively and safely as an alternative modality for the treatment of refractory vitiligo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Vitiligo treatment with monochromatic excimer light and tacrolimus: results of an open randomized controlled study.

Author: NisticòSteven, ChiricozziAndrea, SaracenoRosita, SchipaniCaterina, ChimentiSergio

Effective treatment
Enhanced clinical response
Well tolerated
None mentioned

A combination treatment of 0.1% tacrolimus ointment plus 308-nm excimer light (MEL) and 308-nm MEL monotherapy are effective, safe, and well tolerated for the treatment of vitiligo compared to treatment with vitamin E.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Segmental vitiligo: a randomized controlled trial to evaluate efficacy and safety of 0.1% tacrolimus ointment vs 0.05% fluticasone propionate cream.

Author: KathuriaSushruta, KhaitanBinod K, RamamM, SharmaVinod K

Repigmentation
Transient side effects
Unsatisfactory repigmentation

Tacrolimus and fluticasone propionate produced variable, but overall unsatisfactory, repigmentation in segmental vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Broadband ultraviolet A vs. psoralen ultraviolet A in the treatment of vitiligo: a randomized controlled trial.

Author: El MoftyM, BosseilaM, MashalyH M, GawdatH, MakalyH

Vitiligo treatment
Skin darkening

PUVA and narrowband UVB are treatments for vitiligo, a condition that causes patches of skin to lose color. UVA can cause skin darkening immediately and delayed tanning. This study will investigate the effectiveness of broadband UVA for vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

BB-UVA vs. NB-UVB in the treatment of vitiligo: a randomized controlled clinical study (single blinded).

Author: El-MoftyMedhat, MostafaWedad, YoussefRanda, El-FangaryMona, El-RamlyAmany, MahgoubDoaa, FawzyMarwa, El-HawaryMarwa

Effective for vitiligo

This study evaluated the efficacy of broadband ultraviolet A (BB-UVA) phototherapy compared to narrowband ultraviolet B (NB-UVB) phototherapy for treating vitiligo. BB-UVA showed a significantly higher clinical improvement rate (63.82% ± 27.42) than NB-UVB (44.32% ± 29.78), suggesting BB-UVA as a potential alternative treatment option for vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Treatment of 308-nm excimer laser on vitiligo: A systemic review of randomized controlled trials.

Author: SunYan, WuYan, XiaoBihuan, LiLu, LiLi, ChenHong-Duo, GaoXing-Hua

Equivalent efficacy
Tolerable side effects
Need for more research

The 308-nm excimer laser showed equivalent efficacy to 308-nm excimer lamp control and narrowband-ultraviolet B (NB-UVB) control concerning ≥75% repigmentation rate of vitiligo patches. However, more patients or lesions achieved ≥50% repigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. More studies are needed to confirm the conclusion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Carbon dioxide laser plus topical 5-fluorouracil: a new combination therapeutic modality for acral vitiligo.

Author: MohamedHager A, MohammedGhada F, GomaaAmal H A, EyadaMoustafa M K

CO2 laser + 5FU vitiligo
CO2 laser + 5FU side effects

This study found that the combination of carbon dioxide (CO2) laser skin ablation followed by 5-fluorouracil (5FU) application is a safe and tolerable technique that improves the outcome of acral vitiligo (AV) treatment and increases patient compliance. Almost half of the lesions in the group that received this treatment achieved G4 repigmentation, compared to a significantly lower rate in the other groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Interventions for vitiligo.

Author: WhittonMaxine E, PinartMariona, BatchelorJonathan, Leonardi-BeeJo, GonzálezUrbà, JiyadZainab, EleftheriadouViktoria, EzzedineKhaled

Vitiligo treatment

Vitiligo is a skin condition that causes white patches on the skin. It affects about 1% of the world's population and can appear at any age. Some people experience itching before the patches appear. There are two main types: generalized vitiligo, which affects both sides of the body, and segmental vitiligo, which affects only one side. While there are treatments that can restore pigment, there is no cure for vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Triple combination treatment with fractional CO2 laser plus topical betamethasone solution and narrowband ultraviolet B for refractory vitiligo: a prospective, randomized half-body, comparative study.

Author: LiLu, WuYan, LiLi, SunYan, QiuLi, GaoXing-Hua, ChenHong-Duo

Vitiligo treatment

Vitiligo, a skin condition that causes white patches, is often difficult to treat on the hands, feet, and bony areas. This study examined a combination of laser treatment, a strong steroid cream, and UV light therapy in 25 people with vitiligo in these areas. More than 40% of people saw a significant improvement in pigmentation, and patient satisfaction was higher than in the control group. Side effects were mild. This combination treatment could be a potential option for treating difficult cases of vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Comparative study between excimer light and topical antioxidant versus excimer light alone for treatment of vitiligo.

Author: SolimanMona, SamyNevien Ahmed, Abo EittahMaha, HegazyMisr

Vitiligo treatment

Vitiligo is a skin condition that causes white patches. While various treatments exist, phototherapy is one of the most effective options. Topical medications, sometimes combined with phototherapy, are a common approach.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

Effects of a preceding fractional carbon dioxide laser on the outcome of combined local narrowband ultraviolet B and topical steroids in patients with vitiligo in difficult-to-treat areas.

Author: VachiramonVasanop, ChaiyabutrChayada, RattanaumpawanPinyo, KanokrungseeSilada

Combined treatment for vitiligo

Treating vitiligo on hands and feet often produces less than ideal results. This study aimed to investigate the effectiveness and safety of combining fractional CO2 laser treatment, narrowband UVB (NB-UVB) light therapy, and topical clobetasol propionate for treating stable vitiligo in challenging areas like the hands and feet.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

A Randomized Comparative Study of Oral Corticosteroid Minipulse and Low-Dose Oral Methotrexate in the Treatment of Unstable Vitiligo.

Author: SinghHarsimer, KumaranMuthu Sendhil, BainsAnupama, ParsadDavinder

Arrest disease progression

Oral minipulse therapy (OMP) with betamethasone/dexamethasone has shown promise in arresting disease progression in vitiligo, although a definitive cure remains elusive.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis.

Author: LopesCelso, TrevisaniVirginia Fernandes Moça, MelnikTamara

Repigmentation of vitiligo
Mild adverse effects

This meta-analysis found that excimer lamps, excimer laser, and narrowband ultraviolet B are all safe and effective treatments for vitiligo, with similar efficacy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Triple-combination treatment with oral α-lipoic acid, betamethasone injection, and NB-UVB for non-segmental progressive vitiligo.

Author: LiLi, LiLu, WuYan, GaoXing-Hua, ChenHong-Duo

Safe
Vitiligo improvement

A combination therapy of oral α-lipoic acid, betamethasone injection, and narrowband ultraviolet B (NB-UVB) was found to be effective and safe in treating non-segmental progressive vitiligo. The study showed that α-lipoic acid may accelerate the initial response of repigmentation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo.

Author: MouK H, HanD, LiuW L, LiP

Treatment for vitiligo

This study investigated the effectiveness of glycyrrhizin, UVB, and combined therapy for the treatment of generalized vitiligo. The combination therapy was found to be the most effective and led to improvement in disease stage from active to stable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Fractional CO2 Laser Pretreatment to Autologous Hair Transplantation and Phototherapy Improves Perifollicular Repigmentation in Refractory Vitiligo: A Randomized, Prospective, Half-Lesion, Comparative Study.

Author: FeilyAmir, SeifiVahid, Ramirez-FortMarigdalia K

Improved repigmentation

This study found that fractional CO2 laser pretreatment followed by autologous hair transplantation and narrow-band UVB phototherapy resulted in significantly greater perifollicular repigmentation compared to autologous transplantation and phototherapy alone in patients with refractory and stable vitiligo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis.

Author: LiRonghua, QiaoMeng, WangXiaoyan, ZhaoXintong, SunQing

Increased repigmentation
Similar outcomes

A meta-analysis of seven randomized controlled trials found no significant difference in repigmentation rates between NB-UVB phototherapy combined with topical agents and NB-UVB monotherapy for the treatment of vitiligo. However, combination therapy may be more effective for lesions on the face and neck.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

43.

Pharmacologic Treatment of Vitiligo in Children and Adolescents: A Systematic Review.

Author: de MenezesAndreia Freire, Oliveira de CarvalhoFernanda, BarretoRosana S S, de Santana SilvaBruno, ShanmugamSaravanan, GurgelRicardo Queiroz, de Souza AraújoAdriano Antunes

Disease control
Partial repigmentation
Promising therapies
Unclear which treatment is most effective

This systematic review of 15 studies on vitiligo in children and adolescents found that topical therapies, including tacrolimus, pimecrolimus, corticosteroids, and calcipotriol, showed promising results in achieving disease control and repigmentation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Phototherapy for Vitiligo: A Systematic Review and Meta-analysis.

Author: BaeJung Min, JungHan Mi, HongBo Young, LeeJoo Hee, ChoiWon Joon, LeeJi Hae, KimGyong Moon

Repigmentation of vitiligo

Long-duration phototherapy should be encouraged to enhance the treatment response in vitiligo. The greatest response is anticipated on the face and neck.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol.

Author: MokhtariFatemeh, BostakianAnis, ShahmoradiZabihollah, Jafari-KoshkiTohid, IrajiFariba, FaghihiGita, HosseiniSayed Mohsen, BafandehBehzad

Vitiligo treatment

Vitiligo is a skin condition affecting about 1% of the population worldwide, causing loss of skin pigment. While it doesn't usually cause serious health problems, it can lead to social and emotional distress. While many treatments are available, laser-based therapies are often considered more effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

46.

Combined treatment with fractional carbon dioxide laser, autologous platelet-rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: A prospective, randomized comparative trial.

Author: AbdelghaniRania, AhmedNaglaa A, DarwishHanan M

Repigmentation

Combination of fractional CO2 laser and platelet-rich plasma achieved the best results regarding repigmentation and patient satisfaction in patients with vitiligo.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial.

Author: Razmi TMuhammed, KumarRavinder, RaniSeema, KumaranSendhil M, TanwarSushma, ParsadDavinder

Vitiligo treatment

Treating vitiligo (loss of skin color) with skin grafts (epidermal cell suspension, ECS) and follicular cell suspension (FCS) is effective in some cases. However, achieving repigmentation in widespread vitiligo and areas like the face, hands, and feet is more challenging.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

Preliminary study on the treatment of vitiligo with carbon dioxide fractional laser together with tacrolimus.

Author: ChenWei, ZhouYuan, HuangFei-Ran, LuoDan, WangDa-Guang

Improved repigmentation
Reduced vitiligo severity
Isomorphic response
Scarring

Combined treatment with topical tacrolimus cream and Carbon Dioxide (CO2) laser therapy is an effective treatment for vitiligo. The combination treatment resulted in better improvement in both objective and subjective assessments compared to topical tacrolimus cream alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Combination of fractional carbon dioxide laser with narrow band ultraviolet B to induce repigmentation in stable vitiligo: A comparative study.

Author: DoghaimNoha Nabil, GheidaShereen Farouk, El-TatawyRania Ahmed, Mohammed AliDareen Abdelaziz

Improved repigmentation
Safe treatment

This study evaluated the efficacy and safety of fractional CO2 laser in combination with NB-UVB for treating vitiligo. Patients treated with both therapies showed statistically significant improvement in repigmentation compared to those treated with NB-UVB alone. No notable adverse events were reported. This suggests that fractional CO2 laser may be a promising adjunct to NB-UVB for vitiligo treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

50.

The efficacy of ablation-based combination therapy for vitiligo: A systematic review and meta-analysis.

Author: KingYih-An, TsaiTsung-Yu, TsaiHsiou-Hsin, HuangYu-Chen

Improved repigmentation

Treatments for vitiligo are more effective when combined with ablation therapy than when used alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Evaluation of combined excimer laser and platelet-rich plasma for the treatment of nonsegmental vitiligo: A prospective comparative study.

Author: KhattabFathia M, AbdelbaryEman, FawziMaggie

Improved excimer laser impact
Vitiligo repigmentation
Few side effects

The combination of platelet-rich plasma (PRP) and excimer laser phototherapy was more effective than excimer laser phototherapy alone for vitiligo treatment, leading to a faster onset of reduction in lesion count and improvements in patient satisfaction.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

Noncultured epidermal suspensions obtained from partial-thickness epidermal cuts and suction blister roofs for vitiligo treatment: A prospective comparative study.

Author: AnbarTag S, El-AmmawiTarek S, MohammedSahar S, Abdel-RahmanAmal T

Vitiligo treatment
Variable results

Noncultured epidermal suspension transplantation is an option for treating stable vitiligo that hasn’t responded to medical treatment or phototherapy. However, there is variability in the effectiveness of different techniques used to prepare the suspension.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Repigmentation in vitiligo using janus kinase (JAK) inhibitors with phototherapy: systematic review and Meta-analysis.

Author: PhanKevin, PhanSteven, ShumackStephen, GuptaMonisha

Vitiligo treatment

Vitiligo is a skin condition that causes patches of skin to lose their color. It is caused by the immune system attacking the cells that produce melanin, the pigment that gives skin its color. There is currently no cure for vitiligo, but new treatments are being developed. Studies have shown that JAK1/3 inhibitors, such as tofacitinib and ruxolitinib, may be effective in treating vitiligo. These drugs work by suppressing the immune system, which can help to stop the attack on melanocytes. While more research is needed, these medications have shown promising results in early studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Ruxolitinib cream for treatment of vitiligo: a randomised, controlled, phase 2 trial.

Author: RosmarinDavid, PandyaAmit G, LebwohlMark, GrimesPearl, HamzaviIltefat, GottliebAlice B, ButlerKathleen, KuoFiona, SunKang, JiTao, HowellMichael D, HarrisJohn E

Vitiligo treatment

This study explored the use of ruxolitinib cream as a treatment for vitiligo, a condition causing skin discoloration. While there's no approved cure for vitiligo, current treatments are limited. The study investigated the effectiveness and safety of this cream for restoring skin color over a 52-week period.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

Efficacy and safety of tretinoin 0.05% cream to prevent hyperpigmentation during narrowband UV-B phototherapy in patients with facial vitiligo: a randomized clinical trial.

Author: JuHyun Jeong, KimSoo Hyung, LeeJi Hae, KimGyong Moon, BaeJung Min

Reduced vitiligo hyperpigmentation

Topical tretinoin 0.05% cream effectively prevented hyperpigmentation during narrowband UV-B phototherapy in patients with facial vitiligo without compromising overall treatment response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Microneedling in vitiligo: A systematic review.

Author: SalloumAntoine, BazziNagham, MaaloufDiane, HabreMaya

Vitiligo treatment

Microneedling, initially used for skin rejuvenation, has shown efficacy in treating vitiligo. This review examines the technique, effectiveness, and safety of microneedling for vitiligo, highlighting the potential for this minimally invasive procedure as an alternative treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Randomized controlled trial of topical corticosteroid and home-based narrowband ultraviolet B for active and limited vitiligo: results of the HI-Light Vitiligo Trial.

Author: ThomasK S, BatchelorJ M, AkramP, ChalmersJ R, HainesR H, MeakinG D, DuleyL, RavenscroftJ C, RogersA, SachT H, SanterM, TanW, WhiteJ, WhittonM E, WilliamsH C, CheungS T, HamadH, WrightA, IngramJ R, LevellN J, GouldingJ M R, MakrygeorgouA, BewleyA, OgboliM, StainforthJ, FergusonA, LagudaB, WahieS, EllisR, AzadJ, RajasekaranA, EleftheriadouV, MontgomeryA A,

NB-UVB + TCS effective
Vitiligo treatment success low

A combination of handheld narrowband UVB (NB-UVB) and potent topical corticosteroids (TCS) was more effective than TCS alone for treating localized vitiligo, a condition that causes patches of skin to lose pigmentation. In a randomized controlled trial, 27% of participants achieved treatment success with the combination therapy compared to 17% with TCS alone. However, the combination therapy was only successful in around one-quarter of participants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

A new, innovative, and safe treatment in vitiligo: Results of a randomized, double-blinded, parallel-group study.

Author: DiehlChristian, SadoughifarRoxanna, BinicIva, GolubovicMasa

VITILSI- gel and UVB microphototherapy for vitiligo

This trial compared the efficacy and tolerance of various treatment protocols for vitiligo lesions, finding that the gel VITILSI- alone induced repigmentation and that the combination of VITILSI- and NB-UVB resulted in significantly better outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

59.

Effectiveness of dermabrasion plus 5-fluorouracil vs suction blister in treating vitiligo: A comparative study.

Author: AsilianAli, KazemipourSamira, MokhtariFatemeh, IrajiFariba, ShahmoradiZabihollah, MohagheghFatemeh, MozafarpoorSamaneh, TalakoubMahboobeh

Improved repigmentation
Vitiligo treatment
Short-term follow-up

This study compared the effectiveness of dermabrasion plus 5-fluorouracil and suction blister treatments for persistent refractory vitiligo. Both treatments showed significant improvement in Vitiligo Area Severity Index (VASI) and repigmentation scores within 12 weeks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

60.

Surgical Interventions for Patients With Vitiligo: A Systematic Review and Meta-analysis.

Author: JuHyun Jeong, BaeJung Min, LeeRo Woo, KimSoo Hyung, ParsadDavinder, PourangAunna, HamzaviIltefat, ShourickJason, EzzedineKhaled

Repigmentation

Surgical intervention can be an effective option for refractory stable vitiligo, with a greater than 50% repigmentation rate achieved in 81.01% of patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

Different methods of enhancing the efficacy of topical tacrolimus in extra-facial vitiligo: A comparative study.

Author: EsmatSamia M, GawdatHeba Ismail, HegazyRehab A, AhmedFarah Sayed, SaidEman Raafat

Repigmentation

Microneedling combined with topical tacrolimus may be more effective than monotherapy in treating vitiligo, although further studies are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

62.

Efficacy of topical tacrolimus 0.03% monotherapy in the treatment of non-segmental vitiligo: a randomized, controlled trial.

Author: SalehRamadan, AhmedAml Abd-Elaziz, M Abd-ElmagidWafaa

Repigmentation

Topical tacrolimus 0.03% monotherapy for 24 weeks achieved repigmentation in 45% of patients with non-segmental vitiligo (NSV).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

63.

Oral mini-pulse therapy in vitiligo: a systematic review.

Author: Chavez-AlvarezSonia, Herz-RuelasMaira, Raygoza-CortezAna Karina, Suro-SantosYeudiel, Ocampo-CandianiJorge, Alvarez-VillalobosNeri Alejandro, Villarreal-MartinezAlejandra

OMP therapy
Vitiligo treatment
Weight gain

Oral mini-pulse (OMP) therapy did not show any additional benefit compared to other treatments for nonstable vitiligo. The repigmentation rate was up to 32% when OMP was administered as monotherapy. Weight gain was the most frequent adverse effect. Further studies are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Comparative Evaluation of Efficacy and Safety of Tacrolimus and Dinoprostone Following Dermabrasion in Stable Vitiligo.

Author: KaurJaskirat, KumarSumir, BrarB K, BoparaiAmarbir Singh

Dermabrasion
Dinoprostone
Vitiligo treatment

Dermabrasion followed by dinoprostone gel or tacrolimus ointment showed promising efficacy in treating localized stable vitiligo, with slightly better response observed with tacrolimus.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

65.

The addition of topical calcipotriol to phototherapy enhance the efficacy of treatment in patients with vitiligo: A systematic review and meta-analysis.

Author: HuMengjie, LiaoKexin, LeiWenyi, ZhangRongxin, TuCaixia

Vitiligo treatment
Minor side effects

Combining phototherapy and topical calcipotriol is more effective than phototherapy alone in treating vitiligo. A meta-analysis of nine studies showed that the combination therapy had significantly higher effective and apparent effective rates than phototherapy alone. The combination therapy was well tolerated, with only minor, transient side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Efficacy of narrow band UVB with or without OMP in stabilization of vitiligo activity in skin photo-types (III-V): A double-blind, randomized, placebo-controlled, prospective, multicenter study.

Author: EsmatSamia M, El-MoftyMedhat, RasheedH, MostafaWedad Z, AnbarTag S, AbdallahMarwa, BassiounyDalia, Abdel-HalimDalia, HegazyRehab, EidAmira Abulfotooh, NassarAhmed, Abdel-AzizRasha Ta, FawzyMarwa M, GawdatHeba I, El HawaryMarwa, SanyIman, ShalabySuzan, RagabNanis, Abdel-GaberReham M, TawfikYasmin M, El-BassiounyMahy, El-HusseinyRania, AttiaMiriam Samir, FaridCarmen, GenedyRasha Mahmoud, MogawerRania M

NB-UVB for vitiligo

This study examined the effectiveness of narrowband ultraviolet B (NB-UVB) therapy in stabilizing vitiligo, highlighting the need for more randomized controlled trials to assess its efficacy in dark skin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

67.

Risk of skin cancer after ultraviolet phototherapy in patients with vitiligo: a systematic review and meta-analysis.

Author: WuY-H, ChouC-L, ChangH-C

Safe vitiligo treatment
Skin cancer risk

UV phototherapy is a safe treatment for vitiligo with no significant risk of skin cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Therapeutic effects of turmeric topical cream in vitiligo: A randomized, double-blind, placebo-controlled pilot study.

Author: JalalmaneshSamin, MansouriParvin, RajabiMehdi, MonjiFaezeh

Vitiligo treatment

Vitiligo, a skin condition causing loss of pigment, is common but has no cure, and existing treatments can have side effects. This study explores the potential of turmeric, a spice known for its anti-inflammatory and antioxidant properties, as a treatment for vitiligo.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

70.

The use of lasers in vitiligo, an overview.

Author: PostN F, EzekweN, NarayanV S, BekkenkM W, Van GeelN, HamzaviI, PasseronT, WolkerstorferA

Improved vitiligo repigmentation
Expensive
Limited body surface area

Lasers are effective in treating vitiligo, with the excimer laser showing comparable repigmentation rates to NB-UVB and improved outcomes when combined with calcineurin inhibitors. Ablative lasers are safe and effective for tissue or cell grafts. While Q-switched nanosecond lasers can induce depigmentation, recurrence is common. Despite their effectiveness, laser treatments are expensive and suitable for limited areas.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Surrounding Needling and Narrowband Ultraviolet B Phototherapy Treatment: Synergistic Effects for Repigmentation in Chronic, Stable Nonsegmental Vitiligo.

Author: ChuGong-Yau, WengShih-Ming, HuangChieh-Chen, LiangWen Chun, HsuChung-Hua

Improved vitiligo
Pain

This randomized clinical trial evaluated the efficacy of surrounding needling with acupuncture needles in combination with narrowband ultraviolet B (NBUVB) phototherapy for chronic stable vitiligo. The combination was more effective than NBUVB phototherapy alone.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

72.

Efficacy of local prostaglandin analogues for vitiligo treatment: a systematic review and meta-analysis.

Author: ChangHua-Ching, GuoSiao-Pei

Vitiligo treatment

Vitiligo, a skin condition causing loss of pigment, is common but has no single cure that works for everyone. While some studies suggest that medications called prostaglandin analogues might be helpful in restoring skin color, more research is needed due to inconsistent study design and findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

73.

Utilization of Our Toolkit: A Systematic Review and Meta-analysis of Surgical Therapies in Vitiligo Treatment.

Author: McCraryMyles R, GibbsDavid C, AlharthiMaher, KruegerLoren D

Vitiligo treatment

While vitiligo, a condition causing loss of skin color, is often treated with medication, there's growing evidence for surgical approaches. These techniques, similar to those used for other skin conditions, offer new options for dermatologists treating vitiligo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

74.

Efficacy and safety of oral ritlecitinib for the treatment of active nonsegmental vitiligo: A randomized phase 2b clinical trial.

Author: EzzedineKhaled, PeevaElena, YamaguchiYuji, CoxLori Ann, BanerjeeAnindita, HanGeorge, HamzaviIltefat, GanesanAnand K, PicardoMauro, ThaçiDiamant, HarrisJohn E, BaeJung Min, TsukamotoKatsuhiko, SinclairRodney, PandyaAmit G, SloanAbigail, YuDahong, GandhiKavita, VincentMichael S, KingBrett

Improved vitiligo
Well tolerated

This phase 2b trial evaluated the efficacy and safety of ritlecitinib, an oral JAK3/TEC inhibitor, in patients with active nonsegmental vitiligo. Ritlecitinib was effective in reducing vitiligo severity, with significant differences observed compared to placebo for the 50 mg dose groups, both with and without a loading dose, and the 30 mg group. The drug was well tolerated, with no dose-dependent trends in adverse events.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

75.

The efficacy of adding topical 5-fluorouracil to micro-needling in the treatment of vitiligo: A randomized controlled trial.

Author: PazyarNader, HatamiMohammad, YaghoobiReza, ParvarSeyedeh Yasamin, RadmaneshMohammad, HadibarhaghtalabMaryam

Vitiligo treatment

Vitiligo causes white patches on the skin. While there is no cure, different treatments can help. This study will compare a combination of a procedure called microneedling and a medication called 5-fluorouracil (5-FU) to a medication called tacrolimus for treating vitiligo patches.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

76.

A randomized prospective study to assess the role of topical tacrolimus as preventive therapy in unstable acral vitiligo.

Author: KumarDeepak, ThakurVishal, SubburajKiruthika, BishnoiAnuradha, VinayKeshavamurthy, Sendhil KumaranMuthu, ParsadDavinder

Flare prevention
Vitiligo treatment

Vitiligo on the hands and feet (acral vitiligo) is a difficult-to-treat condition that can be very distressing. The appearance of new patches of depigmentation in these areas can be especially upsetting. Tacrolimus, a medication applied to the skin, is often used for vitiligo and has been shown to help prevent flare-ups in other skin conditions like eczema.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

77.

Efficacy of using oral methotrexate with phototherapy in the treatment of vitiligo in comparison with single phototherapy treatment: A double-blinded randomized controlled trial.

Author: LajevardiVahide, HosseiniZahra Sadat Seyed, HeidariSama

Vitiligo treatment

This study compared the efficacy of methotrexate+ NB-UVB versus placebo+ NB-UVB in vitiligo patients, considering the lack of clear evidence for the superiority of methotrexate over other treatments.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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