著者: CheanJennifer, ChenCharng-Jui, ShivelyJohn E

原題: ETS transcription factor ELF5 induces lumen formation in a 3D model of mammary morphogenesis and its expression is inhibited by Jak2 inhibitor TG101348.

著者: MaoYunuo, WangWei, YangJingwei, ZhouXin, LuYongqu, GaoJunpeng, WangXiao, WenLu, FuWei, TangFuchou

原題: Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids.

著者: GuptaVikas, MascarenhasJohn, KremyanskayaMarina, RampalRaajit K, TalpazMoshe, KiladjianJean-Jacques, VannucchiAlessandro M, VerstovsekSrdan, ColakGozde, DeyDebarshi, HarrisonClaire

原題: Matching-adjusted indirect comparison of the pelabresib-ruxolitinib combination vs JAKi monotherapy in myelofibrosis.

著者: LimK-H, ChangY-C, ChiangY-H, LinH-C, ChangC-Y, LinC-S, HuangL, WangW-T, Gon-Shen ChenC, ChouW-C, KuoY-Y

原題: Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish.

著者: LvYong, XieXiaolong, ZouGuoyou, KongMeng, YangJiayin, ChenJing, XiangBo

原題: SOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway.

著者: KongTim, YuLaYow, LaranjeiraAngelo B A, FisherDaniel A C, HeFan, CoxMaggie J, OhStephen T

原題: Comprehensive profiling of clinical JAK inhibitors in myeloproliferative neoplasms.

著者: RenYumei, YanYongbin, ZhenLei, CaoCaihong, WangQuan, ZhangYingying, ZhuShan

原題: Zhike Pingchuan Granule suppresses interleukin (IL)-6 or the medium of M2 macrophages induced apoptosis in human bronchial epithelial cells.

著者: RaghebMonica, HarrisonClaire N, McLornanDonal P

原題: Current and future role of fedratinib in the treatment of myelofibrosis.

著者: WangXi, DaiChunyan, YinYifei, WuLin, JinWeiyang, FuYufei, ChenZhe, HaoKe, LuBin

原題: Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis.

著者: BrkicSime, MeyerSara C

原題: Challenges and Perspectives for Therapeutic Targeting of Myeloproliferative Neoplasms.

著者: NalairndranGeetha, ChungIvy, Abdul RazackAzad Hassan, ChungFelicia Fei-Lei, HiiLing-Wei, LimWei-Meng, LooiChin King, MaiChun-Wai, LeongChee-Onn

原題: Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells.

著者: StetkaJan, SkodaRadek C

原題: Mouse models of myeloproliferative neoplasms for pre-clinical testing of novel therapeutic agents.

著者: ZhangMeng, XuChristine, MaLei, ShamiyehElias, YinJianyun, von MoltkeLisa L, SmithWilliam B

原題: Effect of food on the bioavailability and tolerability of the JAK2-selective inhibitor fedratinib (SAR302503): Results from two phase I studies in healthy volunteers.

著者: SteinBrady L

原題: JAK inhibition in myelofibrosis: how to sequence treatment in this new era of multiple options.

著者: ColtroGiacomo, VannucchiAlessandro M

原題: The safety of JAK kinase inhibitors for the treatment of myelofibrosis.

著者: Gilzad-KohanHamed, JamaliFakhreddin

原題: Anti-Inflammatory Properties of Drugs Used to Control COVID-19 and their Effects on the Renin-Angiotensin System and Angiotensin-Converting Enzyme-2.

著者: HazellAlan S, AfadlalSzeifoul, ChereshDavid A, AzarAshraf

原題: Treatment of rats with the JAK-2 inhibitor fedratinib does not lead to experimental Wernicke's encephalopathy.

著者: OgasawaraKen, VinceBradley, XuChristine, ZhangMeng, PalmisanoMaria, KrishnaGopal

原題: A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects.

著者:

原題: Zhike pingchuan granules improve bronchial asthma by regulating the IL-6/JAK2/STAT3 pathway.

著者: BewersdorfJan Philipp, JaszczurSara Mohamed, AfifiSalma, ZhaoJennifer C, ZeidanAmer M

原題: Beyond Ruxolitinib: Fedratinib and Other Emergent Treatment Options for Myelofibrosis.

著者: EnglandJames T, GuptaVikas

原題: Fedratinib: a pharmacotherapeutic option for JAK-inhibitor naïve and exposed patients with myelofibrosis.

著者: TefferiAyalew, PardananiAnimesh, GangatNaseema

原題: Momelotinib (JAK1/JAK2/ACVR1 inhibitor): mechanism of action, clinical trial reports, and therapeutic prospects beyond myelofibrosis.

著者: OgasawaraKen, LoRussoPatricia M, OlszanskiAnthony J, RixeOlivier, XuChristine, YinJian, PalmisanoMaria, KrishnaGopal

原題: Assessment of effects of repeated oral doses of fedratinib on inhibition of cytochrome P450 activities in patients with solid tumors using a cocktail approach.

著者: OgasawaraKen, XuChristine, YinJian, DarpoBorje, CarayannopoulosLeon, XueHongqi, PalmisanoMaria, KrishnaGopal

原題: Evaluation of the Potential for QTc Prolongation With Repeated Oral Doses of Fedratinib in Patients With Advanced Solid Tumors.