著者: KunwarSumit, DevkotaAshok Raj, GhimireDipesh K C

原題: Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trials.

著者: DranitsarisGeorge, PeevyhouseAaron, WoodTiffany, KreychmanYuliya, NeuhalfenHeather, MoeziMehdi

原題: Fostamatinib or Thrombopoietic Receptor Agonists for the Treatment of Chronic Immune Thrombocytopenia in Adult Patients: A Real-World Assessment of Safety, Effectiveness and Cost.

著者: McAdooStephen P, ReynoldsJohn, BhangalGurjeet, SmithJennifer, McDaidJohn P, TannaAnisha, JacksonWilliam D, MasudaEsteban S, CookH Terence, PuseyCharles D, TamFrederick W K

原題: Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN.

著者: BurkeRussell T, MeadowsSarah, LoriauxMarc M, CurrieKevin S, MitchellScott A, MaciejewskiPatricia, ClarkeAstrid S, DipaoloJulie A, DrukerBrian J, LannuttiBrian J, SpurgeonStephen E

原題: A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor.

著者: KunwarSumit, DevkotaAshok Raj, GhimireDipesh K C

原題: Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trials.

著者: ThomaGebhard, VeenstraSiem, StrangRoss, BlanzJoachim, VangrevelingheEric, BerghausenJörg, LeeChristian C, ZerwesHans-Günter

原題: Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.

著者: GenoveseMark C, van der HeijdeDésirée M, KeystoneEdward C, SpindlerAlberto J, BenhamouClaude, KavanaughArthur, FudmanEdward, LamplKathy, O'BrienChris, DuffieldEmma L, PoileyJeffrey, WeinblattMichael E

原題: A phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 2 dosing regimens of fostamatinib in patients with rheumatoid arthritis with an inadequate response to a tumor necrosis factor-α antagonist.

著者: MooreDonald C, GebruTsion, MuslimaniAlaa

原題: Fostamatinib for the treatment of immune thrombocytopenia in adults.

著者: WeinblattMichael E, GenoveseMark C, HoMeilien, HollisSally, Rosiak-JedrychowiczKrystyna, KavanaughArthur, MillsonDavid S, LeonGustavo, WangMillie, van der HeijdeDésirée

原題: Effects of fostamatinib, an oral spleen tyrosine kinase inhibitor, in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study.

著者: ColadoAna, AlmejúnMaría Belén, PodazaEnrique, RisnikDenise, StanganelliCarmen, ElíasEsteban Enrique, Dos SantosPatricia, SlavutskyIrma, Fernández GreccoHoracio, CabrejoMaría, BezaresRaimundo Fernando, GiordanoMirta, GamberaleRomina, BorgeMercedes

原題: The kinase inhibitors R406 and GS-9973 impair T cell functions and macrophage-mediated anti-tumor activity of rituximab in chronic lymphocytic leukemia patients.

著者: PamukOmer Nuri, CanGuray, AyvazSuleyman, KaracaTuran, PamukGulsum Emel, DemirtasSelim, TsokosGeorge C

原題: Spleen tyrosine kinase (Syk) inhibitor fostamatinib limits tissue damage and fibrosis in a bleomycin-induced scleroderma mouse model.

著者: MehtaAmit R, KefelaAron, TosteCharina, SweetDonald

原題: Real-World Use of Fostamatinib in Patients with Immune Thrombocytopenia and Thrombotic Risk.

著者: CiudadMarion, OuandjiSethi, LamarthéeBaptiste, CladièreClaudie, GhesquièreThibault, NivetMartin, ThébaultMarine, BoidotRomain, Soudry-FaureAgnès, ChevrierSandy, RichardCorentin, MailletThibault, MaurierFrançois, GreigertHélène, GenetCoraline, RamonAndré, TradMalika, PredanValérie, SaasPhilippe, SamsonMaxime, BonnotteBernard, AudiaSylvain

原題: Regulatory T-cell dysfunctions are associated with increase in tumor necrosis factor α in autoimmune hemolytic anemia and participate in Th17 polarization.

著者: Kjelgaard-PetersenCecilie F, PlattAdam, BraddockMartin, JenkinsMartin A, MusaKishwar, GrahamEmma, GantzelThorbjørn, SlynnGillian, WeinblattMichael E, KarsdalMorten A, ThudiumChristian S, Bay-JensenAnne-C

原題: Translational Biomarkers and Ex Vivo Models of Joint Tissues as a Tool for Drug Development in Rheumatoid Arthritis.

著者: MartinPaul, GillenMichael, MillsonDavid, OliverStuart, BrealeyClive, ElsbyRobert, BaluomMuhammad, LauDavid, MantTim

原題: Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies.

著者: BusselJames B, ArnoldDonald M, BoxerMichael A, CooperNichola, MayerJiri, ZayedHany, TongSandra, DuliegeAnne-Marie

原題: Long-term fostamatinib treatment of adults with immune thrombocytopenia during the phase 3 clinical trial program.

著者: ElsbyRobert, MartinPaul, SurryDominic, SharmaPradeep, FennerKatherine

原題: Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure.

著者: MartinPaul, GillenMichael, MillsonDavid, OliverStuart, BrealeyClive, GrossbardElliott B, BaluomMuhammad, LauDavid, SweenyDavid, MantTim, CravenKelli

原題: Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.

著者: MartinPaul, GillenMichael, MillsonDavid, OliverStuart, BrealeyClive, SurryDominic, SweenyDavid, LauDavid, LeesePhilip

原題: Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies.

著者: HallA Peter, MitchardT, RolfM G, StewartJ, DuffyP

原題: Femoral Head Growth Plate Dysplasia and Fracture in Juvenile Rabbits Induced by Off-target Antiangiogenic Treatment.

著者: StrichJeffrey R, Ramos-BenitezMarcos J, RandazzoDavide, SteinSydney R, BabyakAshley, DaveyRichard T, SuffrediniAnthony F, ChildsRichard W, ChertowDaniel S

原題: Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic.

著者: AliTufail, AnjumFarah, ChoudhuryArunabh, ShafieAlaa, AshourAmal Adnan, AlmalkiAbdulraheem, MohammadTaj, HassanMd Imtaiyaz

原題: Identification of natural product-based effective inhibitors of spleen tyrosine kinase (SYK) through virtual screening and molecular dynamics simulation approaches.

著者: JiangDebbie, Al-SamkariHanny, PanchSandhya R

原題: Changing Paradigms in ITP Management: Newer Tools for an Old Disease.

著者: Le HuuDoanh, KimuraHiroshi, DateMutsumi, HamaguchiYasuhito, HasegawaMinoru, HauKhang Tran, FujimotoManabu, TakeharaKazuhiko, MatsushitaTakashi

原題: Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease.

著者: BusselJames, ArnoldDonald M, GrossbardElliot, MayerJiří, TrelińskiJacek, HomendaWojciech, HellmannAndrzej, WindygaJerzy, SivchevaLiliya, KhalafallahAlhossain A, ZajaFrancesco, CooperNichola, MarkovtsovVadim, ZayedHany, DuliegeAnne-Marie

原題: Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials.