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Incidence of beta-lactam-induced delayed hypersensitivity and neutropenia during treatment of infective endocarditis.

Author: AlestigK, BelinL, HogevikH, OlaisonL

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Long-term parenteral beta-lactam treatment has a high incidence of adverse reactions, particularly after 2 weeks. Penicillin G is the most common culprit.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Long-term parenteral beta-lactam treatment is often complicated by adverse reactions that necessitate drug withdrawal. OBJECTIVE: To evaluate the incidence and mechanism of beta-lactam adverse reactions during an 8-year period in all episodes of suspected infective endocarditis in patie...See full text at original site
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引用元：
https://doi.org/10.1001/archinte.159.6.607

データ提供：米国国立医学図書館（NLM）

Beta-Lactam-Induced Delayed Hypersensitivity and Neutropenia in Infective Endocarditis Treatment

The treatment of infective endocarditis, a serious infection of the heart valves, often involves long-term administration of beta-lactam antibiotics. This study investigates the incidence and mechanism of adverse reactions, such as delayed hypersensitivity and neutropenia, that can occur during beta-lactam treatment.

The study found that delayed adverse reactions were significantly more common with beta-lactam antibiotics compared to vancomycin. Furthermore, the researchers identified penicillin G as the most frequent inducer of adverse reactions among the beta-lactams studied. The study provides insights into the potential immunological mechanisms involved in these adverse reactions.

Understanding the Risks

This study highlights the importance of monitoring patients closely during extended beta-lactam therapy for infective endocarditis. The risk of delayed hypersensitivity and neutropenia can be significant, particularly with penicillin G. This study serves as a reminder that while antibiotics are crucial tools in fighting infection, it's important to understand their potential side effects.

Navigating Infections with Awareness

Infections can feel like a desert storm, unpredictable and potentially dangerous. While antibiotics can provide valuable relief, it's crucial to be aware of their potential side effects. Close monitoring and open communication with healthcare providers can help ensure that patients receive the most effective and safe treatment possible.

Dr.Camel's Conclusion

Infective endocarditis is a serious condition, and the quest for effective treatments continues. This study is like a map through the desert, revealing potential pitfalls and strategies for navigating the treatment landscape. While antibiotics are powerful tools, understanding their potential side effects and the need for careful monitoring is essential in treating this condition.

Date :
  1. Date Completed 1999-04-07
  2. Date Revised 2019-08-12
Further Info :

Pubmed ID

10090118

DOI: Digital Object Identifier

10.1001/archinte.159.6.607

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Languages

English

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