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Pharmacological treatment of alcohol dependence: a review of the evidence.

Author: CareyT S, CrewsF T, GarbuttJ C, LohrK N, WestS L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Naltrexone reduces the risk of relapse to heavy drinking and the frequency of drinking compared with placebo but does not substantially enhance abstinence. Acamprosate reduces drinking frequency. Controlled studies of disulfiram reveal a mixed outcome pattern. The limited data on serotonergic agents were not very promising, and lithium lacks efficacy in the treatment of primary alcohol dependence.
Paper Details　
Original Abstract of the Article :
CONTEXT: Alcoholism affects approximately 10% of Americans at some time in their lives. Treatment consists of psychosocial interventions, pharmacological interventions, or both, but which drugs are most effective at enhancing abstinence and preventing relapse has not been systematically reviewed. O...See full text at original site
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引用元：
https://doi.org/10.1001/jama.281.14.1318

データ提供：米国国立医学図書館（NLM）

Pharmacological Treatment for Alcohol Dependence: A Review of the Evidence

This comprehensive review examines the efficacy of various pharmacological treatments for alcohol dependence. The authors evaluate the evidence for five categories of medications, including disulfiram, naltrexone, acamprosate, serotonergic agents, and lithium. The findings suggest that naltrexone and acamprosate are the most effective medications for reducing drinking frequency and relapse.

Naltrexone and Acamprosate - Promising Medications for Alcohol Dependence

The review concludes that naltrexone and acamprosate are supported by strong evidence as effective treatments for alcohol dependence. These medications have demonstrated a significant ability to reduce drinking frequency and relapse rates, offering hope for individuals struggling with alcohol addiction.

Supporting Recovery: Alcohol Dependence and the Importance of Treatment

This review emphasizes the importance of pharmacological treatment in supporting recovery from alcohol dependence. The findings suggest that certain medications, like naltrexone and acamprosate, can be valuable tools in helping individuals overcome addiction and achieve long-term sobriety.

Dr. Camel's Conclusion

Navigating the treacherous desert of alcohol addiction requires a combination of strategies, including pharmacological support. This review provides valuable insights into the efficacy of various medications, highlighting the potential of naltrexone and acamprosate to help individuals achieve lasting sobriety. The journey to recovery is often long and challenging, but this research offers hope and a roadmap for those seeking a path towards a healthier future.
Date :
  1. Date Completed 1999-04-22
  2. Date Revised 2019-07-01
Further Info :

Pubmed ID

10208148

DOI: Digital Object Identifier

10.1001/jama.281.14.1318

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・Effective treatment of alcohol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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