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Evaluation of tamoxifen dose in advanced breast cancer: a progress report.

Author: BullJ M, LippmanM E, MyersC E, SimonR M, TormeyD C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Tamoxifen (Tam) and Tam plus fluoxymesterone (Flu) were compared in patients with progressive, metastatic breast carcinoma. The combination of Tam and Flu had a higher response rate overall (45% vs 28%) and when only the patients' soft tissue sites were analyzed (54% vs 9%).
Paper Details　
Original Abstract of the Article :
The results of an ongoing trial randomizing patients with progressive, metastatic breast carcinoma between tamoxifen (Tam, NSC-180973) and Tam plus fluoxymesterone (Flu) (7 mg/m2 bid) are reported. Each patient received a single dose level of Tam in the range of 2-100 mg/m2 bid. The combination had ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1021226

データ提供：米国国立医学図書館（NLM）

Tamoxifen: A Promising Treatment for Breast Cancer

This study focuses on the treatment of advanced breast cancer, a challenging condition that affects millions worldwide. It's like navigating a vast, unforgiving desert, where finding the right path to recovery is essential.

The researchers investigated the optimal dosage of tamoxifen, a drug that blocks the action of estrogen, a hormone that can fuel breast cancer growth. Their findings are like discovering a hidden spring in the desert, indicating that lower doses of tamoxifen may be more effective than higher doses. They also discovered that combining tamoxifen with fluoxymesterone, another drug, increased the response rate and time to treatment failure.

This research offers hope to those battling advanced breast cancer. It suggests that careful dose optimization and combination therapy can significantly improve treatment outcomes, potentially leading to longer remission times and improved quality of life.

Tamoxifen and Breast Cancer Treatment

This study underscores the importance of finding the right dose and treatment combination for each individual patient. It suggests that lower doses of tamoxifen may be more effective and that combining it with other drugs can enhance its therapeutic benefits.

Dr. Camel's Conclusion

This research highlights the importance of finding the right path to recovery for those battling breast cancer. It reminds us that even in the face of challenging conditions, there is always hope for a better outcome. Just as the desert holds hidden treasures, the world of medicine offers innovative treatments that can help patients navigate the difficult journey to recovery.

Date :
  1. Date Completed 1977-05-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1021226

DOI: Digital Object Identifier

1021226

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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