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Effect of stiripentol dose on phenytoin-induced teratogenesis in a mouse model.

Author: BajpaiM, BennettG D, FinnellR H, LevyR H, MatherG G, WlodarczykB

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Polytherapy is a potential strategy for managing epilepsy in pregnancy. This study investigated the protective effect of stiripentol (STP) against phenytoin-induced teratogenesis in a mouse model. It found that STP could reduce teratogenicity at a lower dosage, potentially by inhibiting the formation of reactive phenytoin metabolites.
Paper Details　
Original Abstract of the Article :
Previous studies have suggested that polytherapy by design may aid in the management of human pregnancies complicated by epilepsy. However, mechanistic parallels must be drawn between the models of teratogenesis and human pregnancies, and doses of the second agent given to minimize side-effects must...See full text at original site
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引用元：
https://doi.org/10.1016/s0890-6238(98)00067-7

データ提供：米国国立医学図書館（NLM）

Balancing the Risks: Exploring the Protective Effects of Stiripentol against Phenytoin-Induced Teratogenesis

The world of medicine often faces ethical dilemmas when it comes to treating pregnant women with epilepsy, as many anti-epileptic drugs can pose risks to the developing fetus. This study investigates the potential of stiripentol, a medication used to treat epilepsy, to protect against the birth defects caused by phenytoin, another anti-epileptic drug. It's like finding a way to navigate a treacherous desert with minimal risks, ensuring a safe journey for both mother and child.

The researchers used a mouse model to study the effects of stiripentol on phenytoin-induced teratogenesis. They found that stiripentol, at a specific dosage, could significantly reduce the occurrence of birth defects caused by phenytoin. This research suggests that stiripentol might be a valuable tool for mitigating the teratogenic risks associated with phenytoin, but further research is needed to confirm its effectiveness in humans.

Navigating the Risks of Epilepsy Treatment During Pregnancy

This study provides a glimmer of hope for pregnant women with epilepsy, suggesting that stiripentol might offer protection against the teratogenic effects of phenytoin. However, it’s important to remember that this is a preliminary study, and further research is needed before its use in pregnant women can be recommended. As always, consult with your healthcare provider to discuss the risks and benefits of different treatment options for epilepsy during pregnancy.

Dr.Camel's Conclusion

This study explores the potential of stiripentol to protect against phenytoin-induced teratogenesis, offering a potential solution for mitigating the risks associated with anti-epileptic drugs during pregnancy. It’s a reminder that the search for safe and effective treatments for pregnant women with epilepsy is ongoing, and new discoveries are constantly emerging.

Date :
  1. Date Completed 1999-06-23
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

10213515

DOI: Digital Object Identifier

10.1016/s0890-6238(98)00067-7

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・Side Effects of stiripentol
SNS
PICO Info
in preparation
Languages

English

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