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Randomised trial of an inhaled beta2 agonist, inhaled corticosteroid and their combination in the treatment of asthma.

Author: CowanJ O, FlanneryE M, HancoxR J, HerbisonG P, McLachlanC R, TaylorD R, WongC S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aims to investigate the clinical effects of combining beta2 agonists and inhaled corticosteroids in treating asthma, specifically considering the potential for beta2 agonists to reduce the benefit of inhaled corticosteroids.
Paper Details　
Original Abstract of the Article :
Although many asthmatic patients are treated with a combination of beta2 agonist and corticosteroid inhalers, the clinical effects of combining the drugs are unknown. Studies on the early asthmatic response to allergen suggest that beta2 agonists may reduce the benefit of inhaled corticosteroids. A ...See full text at original site
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引用元：
https://doi.org/10.1136/thx.54.6.482

データ提供：米国国立医学図書館（NLM）

Combining Inhaled Beta2 Agonist and Corticosteroid in Asthma Treatment

The world of asthma is like a vast desert with shifting sand dunes of symptoms. Researchers are constantly seeking the right combination of treatments to help patients breathe easier. This study explores the effectiveness of combining inhaled beta2 agonist and inhaled corticosteroid, two common treatments for asthma.

The study aimed to determine whether combining these medications would improve asthma control. While inhaled beta2 agonists are like a cool breeze, providing immediate relief, and inhaled corticosteroids are like a protective barrier, reducing inflammation, the researchers investigated if these two forces could work together harmoniously.

The Question of Synergy

The study found no evidence to support the idea that combining the two drugs improves asthma control. This implies that the two medications may not work synergistically and may even interfere with each other's effectiveness.

Implications for Asthma Management

The findings suggest that doctors should carefully consider the individual needs of each patient when deciding on asthma treatment. While combining these medications may be tempting, it's important to remember that sometimes, less is more, especially when navigating the complexities of asthma management. This study serves as a reminder that the desert of asthma is vast and unpredictable, requiring careful navigation and individualized treatment strategies.

Dr.Camel's Conclusion

This study reminds us that the world of asthma is complex and requires a nuanced approach. While combining inhaled beta2 agonists and corticosteroids might seem logical, the evidence suggests that they may not work together synergistically. The study underscores the importance of individualized treatment plans and careful monitoring of asthma patients, ensuring they find the right balance between symptom relief and long-term control.

Date :
  1. Date Completed 2000-06-16
  2. Date Revised 2019-05-03
Further Info :

Pubmed ID

10335000

DOI: Digital Object Identifier

10.1136/thx.54.6.482

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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