Paper Details

  1. Home
  2. Paper Details

Pharmacokinetics of phenothiazine neuroleptics after chronic coadministration of carbamazepine.

Author: DanielW A, HaduchA, SyrekM, WójcikowskiJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Carbamazepine accelerates the metabolism of thioridazine and promazine in rats, but not perazine. Carbamazepine also inhibits the N-demethylation of thioridazine in vitro, but does not affect its sulfoxidation. Chronic carbamazepine treatment decreased the rate of N-demethylation and accelerated 2-sulfoxidation of thioridazine, both when given alone and when coadministered with thioridazine. Carbamazepine alone significantly increased the rate of perazine N-demethylation, but the effect was less pronounced when carbamazepine was coadministered with perazine. These results suggest that carbamazepine may worsen psychotic symptoms in patients by inducing the metabolism of neuroleptics.
Paper Details　
Original Abstract of the Article :
The aim of the present study was to assess the influence of carbamazepine on the pharmacokinetics of the two phenothiazine neuroleptics thioridazine and perazine in rats. The obtained results are compared with the results of analogical experiments concerning promazine. Thioridazine or perazine (10 m...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/10385926

データ提供：米国国立医学図書館（NLM）

Pharmacokinetics of Phenothiazine Neuroleptics with Carbamazepine

Phenothiazine neuroleptics are a class of medications used to treat psychotic disorders. This study investigates the impact of carbamazepine, an anticonvulsant drug, on the pharmacokinetics of two phenothiazines, thioridazine and perazine, in rats. The authors examine the influence of carbamazepine on the absorption, distribution, metabolism, and excretion of these neuroleptics. Their findings highlight the importance of considering potential drug-drug interactions when prescribing these medications.

Understanding Drug Interactions for Enhanced Patient Safety

The research emphasizes the importance of understanding drug interactions and adjusting medication regimens accordingly to ensure patient safety. The study reveals that carbamazepine can significantly alter the pharmacokinetics of certain phenothiazine neuroleptics, potentially affecting their therapeutic efficacy and increasing the risk of side effects. These findings underscore the need for careful monitoring and appropriate dose adjustments when co-administering these medications.

A Focus on Personalized Medication Management

The study highlights the importance of personalized medication management, considering individual patient factors, such as concurrent medication use, to optimize treatment outcomes and minimize potential risks. It encourages a careful approach to drug prescribing, ensuring that potential interactions are identified and addressed to ensure patient safety.

Dr.Camel's Conclusion

The desert landscape, with its diverse flora and fauna, offers a powerful analogy for the complex interplay of medications within our bodies. This research, like a desert guide carefully navigating a treacherous path, sheds light on the potential interactions between phenothiazine neuroleptics and carbamazepine. By understanding these interactions, we can ensure that our patients receive safe and effective treatment regimens, navigating the complexities of drug therapy with greater precision and care.
Date :
  1. Date Completed 1999-09-08
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

10385926

DOI: Digital Object Identifier

10385926

Related Literature

Article Analysis
・Effects of mesoridazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.