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Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle.
Author: AntónF, BeletaJ, CardelúsI, PalaciosJ M
Original Abstract of the Article :
Allergic conjunctivitis is the most common ocular allergic disease. Although very symptomatic it does not endanger vision, and topical antihistamines or chromones are the first choice treatment in clinical practice. Recently, equivalent nanomolar affinities for histamine H and muscarinic M 1 and M3 ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/s0014-2999(99)00310-6
データ提供：米国国立医学図書館（NLM）
Desloratadine: A Double-Edged Sword in Allergic Conjunctivitis
This study, like a curious camel investigating an unfamiliar oasis, delves into the pharmacological properties of desloratadine, a widely prescribed antihistamine. Researchers, akin to skilled desert explorers, investigated the anticholinergic effects of desloratadine on rabbit and guinea-pig iris smooth muscle. The study found that desloratadine, while effective in blocking histamine receptors, also exhibited significant anticholinergic activity, potentially leading to undesirable side effects such as mydriasis (pupil dilation).
The Desert of Antihistamine Pharmacology: A Complex Landscape
This study, like a detailed map of a vast desert, reveals the intricate landscape of antihistamine pharmacology. It highlights the potential for antihistamines, like desloratadine, to have both beneficial and detrimental effects. The study's findings underscore the importance of careful consideration of potential side effects when prescribing antihistamines, especially for conditions like allergic conjunctivitis, where topical application is common.
Side Effects: A Desert Oasis with Unexpected Twists
Imagine a desert oasis, a welcome respite from the harsh environment. However, sometimes, these oases harbor unexpected challenges. This study reveals the potential for desloratadine, a seemingly beneficial antihistamine, to have unexpected side effects. The study's findings highlight the importance of understanding the potential drawbacks of medications and weighing those risks against the potential benefits.
Dr.Camel's Conclusion
This study underscores the complexities of antihistamine pharmacology, revealing the potential for desloratadine to have both beneficial and undesirable effects. The study's findings, like a warning sign in the desert, highlight the importance of careful consideration of potential side effects when prescribing antihistamines, especially for conditions like allergic conjunctivitis where topical application is common.
Date :
- Date Completed 1999-09-28
- Date Revised 2019-06-24
Further Info :
Related Literature
English
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