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Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome.

Author: CianciA, De LeoV, DittoA, MorganteG, la MarcaA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that pretreatment with metformin reduced the number of follicles greater than 15 mm in diameter and the percentage of cycles with hCG withheld due to excessive follicular development in women with clomiphene-resistant PCOS undergoing FSH stimulation.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate whether pretreatment with metformin improves FSH-induced ovulation in women with clomiphene-resistant polycystic ovary syndrome (PCOS). DESIGN: Randomized prospective trial. SETTING: Department of Obstetrics and Gynecology, University of Siena. PATIENT(S): Twenty women with...See full text at original site
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引用元：
https://doi.org/10.1016/s0015-0282(99)00208-3

データ提供：米国国立医学図書館（NLM）

Metformin: A Potential Catalyst for Ovulation in PCOS

The field of [reproductive endocrinology] is constantly seeking effective treatments for [polycystic ovary syndrome (PCOS)], a common hormonal disorder that can affect [fertility]. This study investigates the potential of [metformin], a medication commonly used to treat [type 2 diabetes], to improve [gonadotropin-induced ovulation] in women with [clomiphene-resistant PCOS]. The research involved a [randomized prospective trial] to assess the effects of [metformin pretreatment] on [FSH-induced ovulation] in women with [PCOS]. The study aimed to determine if metformin could enhance the effectiveness of [FSH stimulation] in these patients.

Metformin: A Potential Boost for Ovulation in PCOS

The study revealed that [metformin pretreatment] led to a significant reduction in the [number of follicles > 15 mm] in diameter on the day of [hCG administration]. The percentage of cycles with [hCG withheld] due to excessive follicular development was also significantly lower in cycles treated with [metformin]. These findings suggest that [metformin] may help to regulate follicular growth and reduce the risk of [ovarian hyperstimulation syndrome (OHSS)] in women with [PCOS].

Metformin: A Potential Pathway to Pregnancy for Women with PCOS

This study provides promising evidence that [metformin] might be a valuable tool for improving [ovulation induction] in women with [PCOS]. The research suggests that [metformin] could potentially enhance the effectiveness of [FSH stimulation] and reduce the risk of [OHSS]. While further research is needed to confirm these findings, this study offers a glimmer of hope for women with [PCOS] who struggle to conceive. The field of [reproductive endocrinology] is a constant quest for solutions, and I find it fascinating how new discoveries emerge to shed light on the complexities of the human reproductive system.

Dr.Camel's Conclusion

This study suggests that metformin pretreatment may improve FSH-induced ovulation in women with clomiphene-resistant PCOS by reducing hyperinsulinism and regulating follicular growth.

Date :
  1. Date Completed 1999-08-30
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

10438996

DOI: Digital Object Identifier

10.1016/s0015-0282(99)00208-3

Related Literature

Article Analysis
・Effective treatment of polycystic ovary syndrome
SNS
PICO Info
in preparation
Languages

English

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