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Randomised placebo-controlled trial of moclobemide, cognitive-behavioural therapy and their combination in panic disorder with agoraphobia.

Author: BenkertO, Graf-MorgensternM, HainC, HautzingerM, LoerchB, SandmannJ, SchlegelS

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cognitive-behavioral therapy (CBT) was highly effective in the treatment of panic disorder with agoraphobia, reducing agoraphobia to levels comparable to those of non-clinical controls. Moclobemide with clinical management was not superior to placebo, and the combination of moclobemide with CBT did not yield significantly better results than CBT with placebo.
Paper Details　
Original Abstract of the Article :
BACKGROUND: In the treatment of panic disorder with agoraphobia, the efficacy of pharmacological, psychological and combined treatments has been established. Unanswered questions concern the relative efficacy of such treatments. AIMS: To demonstrate that moclobemide and cognitive-behavioural therap...See full text at original site
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引用元：
https://doi.org/10.1192/bjp.174.3.205

データ提供：米国国立医学図書館（NLM）

Panic Disorder with Agoraphobia: A Multifaceted Approach to Treatment

This study explores the effectiveness of different treatments for panic disorder with agoraphobia. Imagine feeling trapped in a sandstorm, unable to escape its grip. This is what it's like to experience panic disorder with agoraphobia. This study investigated the effects of both medication (moclobemide) and cognitive-behavioral therapy (CBT) on patients' symptoms. They found that CBT was highly effective on its own, while moclobemide didn't show any significant benefit when used alone. Interestingly, combining the two treatments didn't provide additional short-term advantages compared to CBT alone. However, CBT provided long-lasting benefits, whereas patients who received placebo and CBT alone frequently required additional treatment. This study highlights the importance of tailoring treatment approaches to individual needs and recognizing the effectiveness of CBT for this challenging disorder.

Cognitive-Behavioral Therapy: A Powerful Tool for Treating Panic Disorder

This research offers hope for individuals struggling with panic disorder with agoraphobia. CBT emerged as a highly effective treatment option, providing lasting relief from symptoms and potentially reducing the need for long-term medication.

Overcoming Panic: A Multifaceted Approach

Panic disorder with agoraphobia can be a daunting condition. This study encourages a multidisciplinary approach to treatment, exploring the potential benefits of both therapy and medication to find the best fit for each patient. Remember, you're not alone, and there are resources available to help you navigate this challenging path.

Dr.Camel's Conclusion

This study, like a desert journey, highlights the importance of seeking multiple perspectives and strategies for treatment. CBT emerges as a strong contender, offering a path to recovery for those struggling with panic disorder with agoraphobia. It's like finding a wellspring of hope in the vast desert, providing a refreshing and lasting solution.

Date :
  1. Date Completed 1999-09-02
  2. Date Revised 2019-07-05
Further Info :

Pubmed ID

10448444

DOI: Digital Object Identifier

10.1192/bjp.174.3.205

Related Literature

Article Analysis
・Effective treatment of panic disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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