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Bioavailability of trospium chloride after intravesical instillation in patients with neurogenic lower urinary tract dysfunction: A pilot study.

Author: BihrA M, GrosseJ, KramerG, SchulzH U, SchwantesU, StöhrerM, WalterP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Six men with traumatic spinal cord lesions were randomized to intravesical instillation with 15 or 30 mg trospium chloride. Four positive samples were found in three patients. It is concluded that intravesically instilled trospium chloride is not absorbed into the circulation in significant amounts and, thus, it may be expected that this mode of administration will improve the efficacy of trospium chloride therapy by reducing the side effects.
Paper Details　
Original Abstract of the Article :
Oral drug treatment of detrusor overactivity often causes undesirable side effects in other organs. For some patients, in particular those with neurogenically induced detrusor overactivity (detrusor hyperreflexia), the tolerance level for adverse effects is low and oral treatment may become ineffect...See full text at original site
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引用元：
https://doi.org/10.1002/(sici)1520-6777(1999)18:5<447::aid-nau6>3.0.co;2-q

データ提供：米国国立医学図書館（NLM）

Intravesical Trospium Chloride: A New Route to Bladder Control

Navigating the challenges of neurogenic lower urinary tract dysfunction can feel like traversing a desert with shifting sands, making bladder control unpredictable and challenging. This study investigates the potential of intravesical trospium chloride, a medication typically administered orally, as a new approach to treating detrusor overactivity. The authors conducted a pilot study, involving six men with spinal cord lesions, to assess the bioavailability of trospium chloride after intravesical instillation. They found that the drug was not absorbed into the circulation in significant amounts, suggesting a potential for targeted treatment with fewer systemic side effects.

A Targeted Approach to Bladder Control

The study's findings suggest that intravesical trospium chloride may be a promising alternative to oral administration for treating detrusor overactivity, offering a more targeted approach with potentially fewer side effects.

Finding Stability in the Shifting Sands of Bladder Control

This study provides a glimpse into the potential of intravesical trospium chloride, but further research is needed to confirm its effectiveness and optimize its use. However, it holds promise for offering a new path to improved bladder control for those navigating the challenges of neurogenic lower urinary tract dysfunction.

Dr.Camel's Conclusion

Intravesical trospium chloride offers a potential new route to bladder control, targeting the bladder directly with fewer systemic side effects. However, further research is essential to fully understand its long-term benefits and confirm its efficacy in a larger patient population.
Date :
  1. Date Completed 1999-11-16
  2. Date Revised 2019-11-03
Further Info :

Pubmed ID

10494116

DOI: Digital Object Identifier

10.1002/(sici)1520-6777(1999)18:5<447::aid-nau6>3.0.co;2-q

Related Literature

Article Analysis
・Side Effects of trospium
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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