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Interspecies variability and drug interactions of clozapine metabolism by microsomes.

Author: AubertC, BunH, CatalinJ, DisdierB

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

We compared metabolism formation of clozapine in different species (rat, mouse, guinea-pig, dog, monkey and man) so as to choose between species to further validate interaction studies. The desmethyl- and N-oxide metabolites formed were statistically greater in male than in female rats, mice in the two strains studied, as well as for the guinea-pigs. Levels of desmethyl clozapine formed were high for the rats and no significant difference in clozapine biotransformation was observed between Sprague-Dawley and hairless rats. For man, the formation of metabolites of clozapine was comparable with guinea-pig, dog and monkey.
Paper Details　
Original Abstract of the Article :
Cytochrome P450 expression in liver is influenced by several factors, including species, sex and strain. We compared metabolism formation of clozapine in different species (rat, mouse, guinea-pig, dog, monkey and man) so as to choose between species to further validate interaction studies. Liver mic...See full text at original site
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引用元：
https://doi.org/10.1111/j.1472-8206.1999.tb00364.x

データ提供：米国国立医学図書館（NLM）

Clozapine Metabolism: A Species-Specific Journey

This study delves into the complex world of drug metabolism, exploring how the body breaks down medications like clozapine. Imagine a desert caravan navigating a complex network of paths, each leading to a different destination.

Species-Specific Drug Metabolism

The research highlights the significant variability in clozapine metabolism across different species, revealing the importance of considering species-specific factors in drug development and research. It's like finding the right path through a desert, where the terrain and landscape can vary significantly from one region to the next.

Drug Interactions: A Potential Obstacle

The study also investigates potential drug interactions with clozapine, emphasizing the need for caution when administering this medication alongside other drugs. It's like ensuring that different caravans travelling through the desert do not collide with one another.

Dr. Camel's Conclusion

This research reveals the intricate nature of drug metabolism, a process that can vary significantly across species. It highlights the importance of considering species-specific factors in drug development and research, much like navigating a complex desert landscape. The study also underscores the potential for drug interactions, a factor that must be carefully considered when prescribing medications.

Date :
  1. Date Completed 1999-11-10
  2. Date Revised 2019-10-24
Further Info :

Pubmed ID

10520731

DOI: Digital Object Identifier

10.1111/j.1472-8206.1999.tb00364.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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