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Stiripentol: efficacy and tolerability in children with epilepsy.

Author: BlehautH, ChironC, DulacO, MusialC, PerezJ, ReyE, VincentJ, d'AthisP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Stiripentol (STP) was found to be an effective add-on therapy for refractory epilepsy in children, particularly when combined with carbamazepine (CBZ) for partial epilepsy and with clobazam (CLB) for severe myoclonic epilepsy in infancy.
Paper Details　
Original Abstract of the Article :
PURPOSE: Stiripentol (STP) is a new antiepileptic drug (AED) that inhibits cytochrome P450, resulting in increased plasma concentrations of concomitant AEDs. The efficacy and tolerability of STP as an add-on therapy in children were assessed. METHODS: Two hundred twelve patients with refractory epi...See full text at original site
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引用元：
https://doi.org/10.1111/j.1528-1157.1999.tb02048.x

データ提供：米国国立医学図書館（NLM）

Stiripentol: A Promising Add-on Therapy for Refractory Epilepsy

This research examines the efficacy and tolerability of stiripentol (STP), a new antiepileptic drug, as an add-on therapy for children with refractory epilepsy. The authors conducted both a placebo-controlled trial and an open trial, investigating the effects of STP in children with different epilepsy syndromes. Their findings suggest that STP can be an effective add-on therapy, particularly in combination with certain other antiepileptic drugs, and is generally well tolerated.

Stiripentol: A Potential Breakthrough in Epilepsy Treatment

The study found that STP significantly reduced seizure frequency in children with refractory epilepsy. The highest response rates were observed in patients with partial epilepsy, particularly those receiving carbamazepine (CBZ) as comedication. STP also showed promising results in children with severe myoclonic epilepsy in infancy when combined with clobazam (CLB). The drug was generally well-tolerated, with the most common side effects being anorexia and weight loss.

Managing Epilepsy in Children: A Collaborative Approach

This research offers a promising new treatment option for children with refractory epilepsy. Stiripentol (STP), when used as an add-on therapy, can be an effective tool for reducing seizure frequency and improving quality of life for these children. However, it's essential to remember that epilepsy is a complex condition, and the best treatment plan will vary depending on individual needs. A collaborative approach, involving healthcare professionals and specialized epileptologists, is crucial for determining the most appropriate treatment strategy.

Dr.Camel's Conclusion

Like a wise camel navigating the unpredictable desert terrain of epilepsy, researchers are constantly seeking new ways to alleviate this debilitating condition. This study highlights the potential of stiripentol (STP) as a valuable tool for managing seizures in children. Remember, every journey through epilepsy is unique, and finding the right path to manage seizures requires careful consideration and guidance from specialized healthcare professionals.

Date :
  1. Date Completed 1999-11-26
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

10565591

DOI: Digital Object Identifier

10.1111/j.1528-1157.1999.tb02048.x

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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