Drug interaction between cimetidine and timolol ophthalmic solution: effect on heart rate and intraocular pressure in healthy Japanese volunteers.

Author: IshiiY, KotegawaT, NakamuraK, NakanoS, NakatsukaK, TsutsumiK

Paper Details 
Original Abstract of the Article :
Systemic adverse effects of timolol ophthalmic solution given at usual therapeutic doses have been well characterized. Timolol is partially metabolized by cytochrome P450 (CYP) 2D6. Cimetidine inhibits the activity of cytochrome P450, including CYP2D6, leading to reduced systemic clearance of concom...See full text at original site
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引用元:
https://doi.org/10.1177/00912700022008739

データ提供:米国国立医学図書館(NLM)

Drug Interaction Between Cimetidine and Timolol Ophthalmic Solution

Timolol ophthalmic solution is a common medication used to treat glaucoma, but it can interact with other drugs. This study examines the effects of coadministering cimetidine, a medication used for heartburn and ulcers, with timolol ophthalmic solution in healthy Japanese volunteers. The researchers found that coadministration of cimetidine with timolol resulted in increased beta-blockade, as evidenced by reductions in heart rate and intraocular pressure.

Navigating the Desert of Drug Interactions: Understanding the Effects of Cimetidine and Timolol

This study highlights the importance of understanding potential drug interactions, especially when medications are used for different conditions. It's like navigating a desert, where unexpected hazards can arise when different paths converge. This research underscores the importance of careful consideration of potential interactions when prescribing medications, especially for patients taking multiple drugs.

A Desert Oasis: Finding Safe and Effective Treatment

This research emphasizes the need for careful monitoring of patients taking medications known to interact with each other. It's like providing a desert oasis with a vigilant guard, ensuring that patients are protected from potential dangers. By understanding the potential risks of drug interactions, we can work to ensure that patients receive the best possible care.

Dr. Camel's Conclusion

This study serves as a valuable reminder of the importance of understanding potential drug interactions. It's like a beacon of light in the desert, guiding us to safe and effective treatment approaches. By carefully considering the potential risks and benefits of medications and their interactions, we can provide the best possible care for our patients.

Date :
  1. Date Completed 2000-02-17
  2. Date Revised 2019-08-26
Further Info :

Pubmed ID

10664926

DOI: Digital Object Identifier

10.1177/00912700022008739

Related Literature

SNS
PICO Info
in preparation
Languages

English

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