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Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte.

Author: EgoshiK, HattoriT, SakakibaraR, SekitaN, SuenagaT, TakahashiH, UchiyamaT, YamanishiT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prazosin and moxisylyte, alpha-1 adrenergic receptor blockers, are effective in improving bladder emptying in patients with multiple system atrophy. However, they can cause orthostatic hypotension.
Paper Details　
Original Abstract of the Article :
Lower urinary tract dysfunction is a major cause of morbidity in patients with multiple system atrophy (MSA). alpha1-Adrenergic receptors are present in the proximal urethra where impaired relaxation may be responsible for voiding difficulty and a large amount of residual urine. An open study was de...See full text at original site
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引用元：
https://doi.org/10.1016/s0165-1838(99)00105-8

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2000-04-18
  2. Date Revised 2019-09-10
Further Info :

Pubmed ID

10699651

DOI: Digital Object Identifier

10.1016/s0165-1838(99)00105-8

Related Literature

Article Analysis
・Side Effects of prazosin
SNS
PICO Info
in preparation
Languages

English

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