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Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte.

Author: EgoshiK, HattoriT, SakakibaraR, SekitaN, SuenagaT, TakahashiH, UchiyamaT, YamanishiT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prazosin and moxisylyte, alpha-1 adrenergic receptor blockers, are effective in improving bladder emptying in patients with multiple system atrophy. However, they can cause orthostatic hypotension.
Paper Details　
Original Abstract of the Article :
Lower urinary tract dysfunction is a major cause of morbidity in patients with multiple system atrophy (MSA). alpha1-Adrenergic receptors are present in the proximal urethra where impaired relaxation may be responsible for voiding difficulty and a large amount of residual urine. An open study was de...See full text at original site
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引用元：
https://doi.org/10.1016/s0165-1838(99)00105-8

データ提供：米国国立医学図書館（NLM）

Alpha-Blockers: A Potential Solution for Lower Urinary Tract Dysfunction in MSA

Multiple system atrophy (MSA) is a debilitating neurological disorder that can severely impact bladder function. This study investigates the role of alpha-blockers, specifically prazosin and moxisylyte, in improving bladder emptying in MSA patients. The authors employed an open study design to assess the effectiveness of these medications in alleviating lower urinary tract dysfunction.

Unlocking the Bladder: A New Approach to MSA Management

The research demonstrates that both prazosin and moxisylyte significantly reduced post-micturition residual urine volume, suggesting their potential as effective treatments for lower urinary tract dysfunction in MSA. The study also highlights the need for cautious use of these medications in patients with pre-existing postural hypotension.

Navigating the Challenges of MSA

This research provides a ray of hope for individuals with MSA, offering a potential therapeutic avenue for managing bladder dysfunction. It emphasizes the importance of personalized medicine, taking into account individual patient characteristics and potential risks. This study is like finding a hidden spring in the desert, providing relief and sustenance for those struggling with a challenging condition.

Dr. Camel's Conclusion

This research provides valuable insights into the potential of alpha-blockers in managing lower urinary tract dysfunction associated with MSA. The findings underscore the importance of careful patient selection and monitoring, highlighting the crucial role of personalized medicine in addressing the unique challenges of this neurological disorder.

Date :
  1. Date Completed 2000-04-18
  2. Date Revised 2019-09-10
Further Info :

Pubmed ID

10699651

DOI: Digital Object Identifier

10.1016/s0165-1838(99)00105-8

Related Literature

Article Analysis
・Side Effects of prazosin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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