Side Effects of prazosin: A Synthesis of Findings from 17 Studies

  1. Home
  2. Side Effects of prazosin
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of prazosin: A Synthesis of Findings from 17 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of prazosin: A Synthesis of Findings from 17 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

Prazosin has been found effective in treating hypertension, benign prostatic hyperplasia (BPH), Raynaud's phenomenon, and nightmares associated with post-traumatic stress disorder (PTSD) in various studies. 15 , 2 , 10 , 6

However, it's important to note that prazosin can also cause side effects, many of which are dose-dependent.

Reasons for Side Effects

Prazosin works by blocking α1-adrenergic receptors, which in turn inhibits vasoconstriction and lowers blood pressure. This mechanism is believed to be responsible for some of prazosin's side effects. 17

Common Side Effects

Dizziness

Prazosin can induce dizziness. This occurs because prazosin dilates blood vessels, decreasing blood pressure and reducing blood flow to the brain when standing up. 17 , 14 , 10 , 8

Headache

Prazosin can cause headache. This is because prazosin dilates blood vessels, increasing blood flow and triggering headache. 1

Gastrointestinal Symptoms

Prazosin can lead to gastrointestinal symptoms such as nausea, vomiting, and abdominal pain. 1

Fatigue

Prazosin can cause fatigue. This is because prazosin dilates blood vessels, lowering blood pressure and making the body feel tired. 2

Sexual Dysfunction

Prazosin can contribute to sexual dysfunction like erectile dysfunction. This occurs because prazosin dilates blood vessels, reducing blood flow to the penis. 2

Countermeasures for Side Effects

Countermeasures for Dizziness

To prevent dizziness, it's essential to avoid standing up too quickly after taking prazosin. Staying hydrated and reducing salt intake can also be beneficial. 8

Countermeasures for Headache

If you experience a severe headache, consult your doctor. They might prescribe a pain reliever. 1

Countermeasures for Gastrointestinal Symptoms

If you have concerns about gastrointestinal symptoms, consult your doctor. Dietary therapy and drug therapy may be helpful. 1

Countermeasures for Fatigue

If you experience severe fatigue, consult your doctor. If the cause is prazosin, you might be switched to a different medication. 2

Countermeasures for Sexual Dysfunction

If you are concerned about sexual dysfunction, consult your doctor. If the cause is prazosin, you might be switched to a different medication. 2

Comparison between Studies

Commonalities of Studies

Most studies indicate that prazosin is effective in improving a range of symptoms. However, it has also been reported that prazosin can cause side effects. 14 , 10 , 2 , 8 , 15 , 1 , 6 , 7

Differences between Studies

The effectiveness and severity of prazosin side effects can vary depending on the patient's condition and dosage. 10 ,

Notes on Application to Daily Life

Prazosin is an effective drug, but you need to consider the risk of side effects. When taking prazosin, it is essential to follow your doctor's instructions and take the correct dosage. If you experience any side effects, consult your doctor immediately. 15 , 2 , 10 , 8 , 17 , 14 , 1 , 6 , 7

Limitations of Current Research

Research on the effects and side effects of prazosin is still inadequate. Further studies are needed, particularly regarding the impact of long-term prazosin use. 15 , 2 , 10 , 8 , 17 , 14 , 1 , 6 , 7

Future Research Directions

Research on the long-term effects and side effects of prazosin is required. Moreover, further research on the interactions of prazosin with other medications is necessary. 15 , 2 , 10 , 8 , 17 , 14 , 1 , 6 , 7

Conclusion

Prazosin can be an effective medication for a variety of conditions, but it is important to be aware of the potential side effects. If you are taking prazosin, adhere to your doctor's instructions and consult them immediately if you experience any side effects. 15 , 2 , 10 , 8 , 17 , 14 , 1 , 6 , 7

Literature analysis of 17 papers
Positive Content
15
Neutral Content
0
Negative Content
2
Article Type
4
1
1
4
17
1.

Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya.

Author: JaokoW G, MuchemiG, OguyaF O

Praziquantel
Schistosomiasis treatment
Abdominal pain
Headache
Nausea

Praziquantel was well-tolerated with mild and transient side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Alpha blockers in use for symptomatic benign prostatic hyperplasia--are all drugs born equal?].

Author: Bar-YosefYuval, MabjeeshNicola J, LauferMenachem, NeulanderEndre Z, KaverIsaac, MatzkinHaim

BPH treatment
Ejaculatory dysfunction
Hypotension

This paper compares the efficacy and adverse events profile of four alpha-adrenergic blockers used for the treatment of symptomatic benign prostatic hyperplasia (BPH): terazosin, doxazosin, alfuzosin, and tamsulosin. Alfuzosin and tamsulosin are preferred due to their better tolerability and ease of use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Hebrew

3.

The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An update on management of behavioral and psychological symptoms in dementia.

Author: ChenAnderson, CopeliFrank, MetzgerEran, CloutierAlesia, OsserDavid N

BPSD management
Adverse effects

This article provides updated algorithms for the use of psychopharmacologic agents in geriatric patients with dementia and behavioral and psychological symptoms of dementia (BPSD). The algorithms consider recent research and provide recommendations for emergent, urgent, and non-urgent settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Management of American Heart Association/American College of Cardiology-Defined Stage 2 Hypertension by Cardiologists in India.

Author: RamC Venkata S, DalalJamshed, KahaliDhiman, MohananPadhinhare P, DasMrinal Kanti, GuhaSantanu, NairTiny, NarasimhanCalambur, RoyDevanu Ghosh, AbdullakuttyJabir, RaySoumitra, FulwaniMahesh, MohanJagdish Chander, GuptaRajeev, AbhyankarMahesh, RevankarSantosh

Hypertension management
Ankle edema

Uncontrolled hypertension is a major cardiovascular risk factor, and effective management is crucial. This study assessed the approaches to managing patients with Stage 2 hypertension by cardiologists in India. The study found that triple or even higher combinations of antihypertensive medications were commonly used. The most prevalent comorbidity in the study population was diabetes mellitus.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The efficacy of prazosin for the treatment of posttraumatic stress disorder nightmares in U.S. military veterans.

Author: BreenAnnamarie, BlankleyKory, FineJulie

Nightmare relief

This review explores the use of prazosin, a medication commonly used to treat high blood pressure, for treating nightmares associated with posttraumatic stress disorder (PTSD) in military veterans. Prazosin has shown promise in reducing the frequency and severity of nightmares in veterans, providing a potential alternative to traditional PTSD treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte.

Author: SakakibaraR, HattoriT, UchiyamaT, SuenagaT, TakahashiH, YamanishiT, EgoshiK, SekitaN

Improved bladder emptying
Lessening of urinary symptoms
Reduced residual urine volume
Orthostatic hypotension

Prazosin and moxisylyte, alpha-1 adrenergic receptor blockers, are effective in improving bladder emptying in patients with multiple system atrophy. However, they can cause orthostatic hypotension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Dose-response study of prazosin in Raynaud's phenomenon: clinical effectiveness versus side effects.

Author: WollersheimH, ThienT

Raynaud's phenomenon treatment
Orthostatic hypotension

Prazosin, a medication for Raynaud's phenomenon, was effective at 3 mg daily. Higher doses did not show a significant increase in effectiveness but had a higher incidence of side effects, particularly orthostatic hypotension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Medical therapy for benign prostatic hyperplasia: a review of the literature.

Author: CliffordG M, FarmerR D

BPH treatment
Prostate size reduction
Prostatic smooth muscle relaxation

Alpha-blockers, such as prazosin, alfuzosin, indoramin, terazosin, doxazosin, and tamsulosin, relax prostatic smooth muscle and can benefit patients with benign prostatic hyperplasia (BPH). Finasteride, an anti-androgen, reduces prostate size and has long-term benefits for BPH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Sleep Disturbances and Nightmares in a Patient Treated with Prazosin.

Author: KosariSam, NauntonMark

Nightmares
Sleep disturbances

A case report suggests that low-dose prazosin, used for treating nightmares in patients with posttraumatic stress disorder, may be associated with nightmares and sleep disturbances in some elderly patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Efficacy and side-effects of prazosin as a symptomatic treatment of benign prostatic obstruction.

Author: RuutuM L, HanssonE, JuuselaH E, PermiJ E, RuskJ I, SotarautaM T, TaljaM T, WuokkoE J, MattilaM J

Improved voiding
Lower blood pressure
Postural dizziness

Prazosin is an alpha 1-adrenoceptor blocking drug that has been shown to improve voiding in some patients with benign prostatic obstruction. In a study of 35 patients, prazosin increased both the maximum and mean flow rates, as well as the voided volumes. The most common side effect of prazosin was postural dizziness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

A randomized, controlled, multicenter study to compare prazosin GITS with enalapril in hypertensive patients with diabetes mellitus. Bombay Hypertension Study Group.

Author: JoglekarS J, NanivadekarA S

Hypertension treatment
Lipid lowering

Prazosin GITS and enalapril were both effective in controlling hypertension in patients with diabetes mellitus. A randomized, controlled study involving 89 patients found that both drugs effectively lowered blood pressure. Prazosin GITS had a beneficial effect on serum triglycerides, while enalapril had a favorable effect on triglycerides but a detrimental effect on LDL cholesterol. Both drugs increased fasting blood sugar and 2-hour post-meal blood sugar levels, but this was more significant in the prazosin GITS group. Prazosin GITS was also associated with fewer adverse events compared to enalapril.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Nandrolone treatment decreases the level of rat kidney alpha(1B)-adrenoceptors.

Author: UhlénStaffan, LindblomJonas, KindlundhAnna, MugishaPaul, NybergFred

Fluid retention
Hypertension

This study investigated the effects of the anabolic androgenic steroid nandrolone decanoate on renal alpha-adrenoceptors in rats. The results showed a significant reduction in kidney alpha(1B)-adrenoceptors, which may contribute to the hypertension and fluid retention associated with AAS abuse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.