Paper Details 
Original Abstract of the Article :
Type 2 diabetes mellitus is a progressive disorder, and although oral monotherapy is often initially successful, it is associated with a high secondary failure rate, which contributes to the development of long-term diabetes complications resulting from persistent hyperglycemia. For patients not tak...See full text at original site
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引用元:
https://doi.org/10.1016/s0002-9343(00)00338-7

データ提供:米国国立医学図書館(NLM)

Type 2 Diabetes: A Journey Through the Desert of Glucose Control

In the vast desert of diabetes management, finding the right combination of therapies to control blood glucose levels is a constant challenge. This study delves into the complexities of combination therapy for type 2 diabetes, exploring the potential of combining sulfonylureas with other oral antidiabetic agents. The authors highlight the progressive nature of type 2 diabetes and the high failure rate of monotherapy, emphasizing the need for more effective treatment strategies. Combination therapy offers a potential solution, addressing both insulin deficiency and insulin resistance, which are the two main pillars of this disease. While the combination of sulfonylureas and metformin is well-studied, the research also explores other promising combinations, such as sulfonylureas with alpha-glucosidase inhibitors or thiazolidinediones. The authors suggest that combination therapy may be an appropriate primary management strategy early in the disease course, while later in the disease, it can help delay the need for insulin. This comprehensive approach aims to improve glycemic control and potentially delay the development of long-term complications.

Combination Therapy: Finding the Right Oasis in the Diabetes Desert

This study suggests that combining different oral antidiabetic agents can be a powerful tool in controlling blood glucose levels in patients with type 2 diabetes. The authors emphasize that this approach can address both insulin deficiency and insulin resistance, the two key factors driving the disease. Combining sulfonylureas with metformin appears to be a particularly effective strategy, but other combinations are also being investigated. This research offers valuable insights into optimizing diabetes management, potentially improving outcomes for patients and delaying the progression of the disease.

Living with Diabetes: Navigating the Desert with a Wise Guide

This research offers a glimmer of hope in the desert of diabetes management. It suggests that by understanding the complex interplay of different medications, we can find a personalized treatment strategy that best suits our needs. The study's findings emphasize the importance of working closely with your doctor to determine the best course of action for managing your diabetes and preventing long-term complications. Remember, just as a wise traveler navigates the desert with a map and compass, a proactive approach to your diabetes management, guided by a healthcare professional, can lead you to a healthier and more comfortable journey.

Dr.Camel's Conclusion

This research emphasizes the importance of combination therapy in managing type 2 diabetes. By addressing both insulin deficiency and insulin resistance, these treatments can help control blood glucose levels and potentially prevent long-term complications. Finding the right combination of medications, guided by your doctor, can be the key to navigating the desert of diabetes management.

Date :
  1. Date Completed 2000-06-01
  2. Date Revised 2019-06-27
Further Info :

Pubmed ID

10764846

DOI: Digital Object Identifier

10.1016/s0002-9343(00)00338-7

Related Literature

SNS
PICO Info
in preparation
Languages

English

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