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Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: a randomized study.

Author: BecquartD, BeexL V, BurghoutsJ, DuchateauL, JassemJ, KlijnJ G, MauriacL, MignoletF, PiccartM, SeynaeveC, VeyretC, WildiersJ, van ZijlJ A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Combining estrogen suppression with buserelin and estradiol receptor blockade with tamoxifen reduced the high estradiol levels induced by tamoxifen, potentially improving antitumor effects in premenopausal women with breast cancer.
Paper Details　
Original Abstract of the Article :
Surgical or medical castration and antiestrogenic treatment with tamoxifen are common endocrine treatments for premenopausal women with breast cancer. However, tamoxifen therapy induces high levels of plasma estradiol, with unknown long-term effects. In this study, we investigated the effect of comb...See full text at original site
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引用元：
https://doi.org/10.1093/jnci/92.11.903

データ提供：米国国立医学図書館（NLM）

Combined Treatment with Buserelin and Tamoxifen in Premenopausal Metastatic Breast Cancer

This research examines the treatment of [premenopausal metastatic breast cancer], a challenging disease that requires a multifaceted approach. The study investigated the potential benefits of combining two commonly used medications: [buserelin] and [tamoxifen].

A Multifaceted Approach to Breast Cancer Treatment

The study explored the potential of combining [estrogen suppression] with [buserelin] and [estradiol receptor blockade] with [tamoxifen]. The research suggested that this combination could reduce the high estradiol levels induced by tamoxifen and potentially improve antitumor effects.

Personalized Treatment for Breast Cancer

This research underscores the need for a [personalized treatment approach] for breast cancer, tailoring therapy to the specific needs of each patient. The study’s findings suggest that combining different medications may offer a more effective and targeted treatment strategy for premenopausal women with metastatic breast cancer.

Dr.Camel's Conclusion

This research is a reminder that, just as a camel navigates the vast and complex desert, healthcare providers must navigate the complex landscape of breast cancer treatment. By embracing a personalized approach and exploring innovative combinations of therapies, we can work towards more effective and individualized treatment plans for patients with this challenging disease.
Date :
  1. Date Completed 2000-07-18
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

10841825

DOI: Digital Object Identifier

10.1093/jnci/92.11.903

Related Literature

Article Analysis
・Effects of tamoxifen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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