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The effectiveness of omeprazole, clarithromycin and tinidazole in eradicating Helicobacter pylori in a community screen and treat programme. Leeds Help Study Group.

Author: AthaP, AxonA T, BrownJ, CrocombeW, DowellA C, FeltbowerR, MasonS, MoayyediP, RichardsI D

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The eradication rate of H. pylori was 61% in an intention-to-treat analysis, which is less successful than hospital studies in dyspeptic patients. Adverse events occurred in 45% of the treatment group.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Helicobacter pylori screening and treatment has been proposed as a cost-effective method of preventing gastric cancer. AIM: To assess, in a randomized controlled trial, the efficacy of therapy in eradicating H. pylori as part of a screening programme, and to report the adverse events ...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.2000.00767.x

データ提供：米国国立医学図書館（NLM）

Effectiveness of Omeprazole, Clarithromycin, and Tinidazole

In the vast desert of gastrointestinal research, scientists are constantly seeking new and effective therapies to manage common digestive disorders. This study investigates the effectiveness of a triple therapy regimen consisting of omeprazole, clarithromycin, and tinidazole in eradicating Helicobacter pylori, a bacterium that can cause gastritis, ulcers, and even stomach cancer.

Triple Therapy: A Powerful Oasis in the Desert of Helicobacter pylori

The study demonstrates that the OCT regimen is effective in eradicating H. pylori, achieving an eradication rate of 61% in the intention-to-treat analysis. However, the eradication rate was lower than that observed in previous hospital-based studies, suggesting that the effectiveness of this regimen may be influenced by factors related to community-based screening programs.

Navigating the Landscape of H. pylori Treatment: A Journey Through the Digestive System

The study highlights the importance of considering the context in which therapies are implemented. The effectiveness of a treatment regimen can be influenced by factors such as patient compliance, access to healthcare services, and the presence of other underlying conditions. This research underscores the need for a comprehensive approach to managing H. pylori infection, addressing both the medical and social determinants of health.

Health Implications and Lifestyle Applications: Protecting Our Digestive Health

This study emphasizes the importance of screening and treating H. pylori infection to prevent long-term health complications. It highlights the need for a multifaceted approach to managing this common infection, including appropriate medication, lifestyle modifications, and ongoing monitoring.

Dr. Camel's Conclusion

This study reminds us that the desert of digestive health can be a challenging landscape. By understanding the effectiveness and limitations of treatment regimens like OCT, we can develop more effective strategies for managing H. pylori infection and protecting our digestive health. It's important to consult with a healthcare professional to determine the best course of treatment for your individual needs.
Date :
  1. Date Completed 2000-08-01
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

10848655

DOI: Digital Object Identifier

10.1046/j.1365-2036.2000.00767.x

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・Effects of omeprazole clarithromycin
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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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