Paper Details

  1. Home
  2. Paper Details

Pharmacologic approach to the maintenance of urate homeostasis.

Author: KelleyW N

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Probenecid, sulfinpyrazone, and allopurinol are the three most commonly used hypouricemic drugs, each working by increasing uric acid excretion, inhibiting its synthesis, or a combination of both. The drugs were discussed in detail regarding their mechanisms of action, metabolism, metabolic effects, side effects, and interactions with other drugs. Guidelines for their use in hyperuricemic subjects were proposed.
Paper Details　
Original Abstract of the Article :
A reduction in the serum urate concentration in hyperuricemic subjects can be achieved by increasing the renal excretion of uric acid, by inhibiting its synthesis, or by a combination of both modalities. The three most commonly used hypouricemic drugs are probenecid, sulfinpyrazone and allopurinol. ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1159/000180439

データ提供：米国国立医学図書館（NLM）

Maintaining Urate Homeostasis: Pharmacologic Approaches

Understanding the intricate mechanisms of our body's metabolic processes is key to addressing health issues. This review explores the pharmacologic approach to managing hyperuricemia, a condition characterized by elevated serum uric acid levels. The authors delve into the mechanisms of action of various hypouricemic drugs, such as probenecid, sulfinpyrazone, and allopurinol, providing a comprehensive overview of their uses, side effects, and interactions.

Balancing Uric Acid Levels: A Guide to Hypouricemic Drugs

This review offers a detailed analysis of the three most commonly used hypouricemic drugs - probenecid, sulfinpyrazone, and allopurinol. The authors provide insights into their mechanisms of action, metabolism, potential side effects, and drug interactions, offering a valuable resource for understanding these medications.

Managing Hyperuricemia: A Multifaceted Approach

The review emphasizes the importance of a multidisciplinary approach to managing hyperuricemia. It highlights the role of lifestyle modifications, such as diet and exercise, in conjunction with medication, to effectively control uric acid levels.

Dr.Camel's Conclusion

This comprehensive review provides a valuable guide to understanding the pharmacologic approaches to managing hyperuricemia. It offers insights into the mechanisms of action, potential side effects, and interactions of various hypouricemic drugs, aiding in the development of effective treatment strategies.

Date :
  1. Date Completed 1975-07-07
  2. Date Revised 2018-02-15
Further Info :

Pubmed ID

1091870

DOI: Digital Object Identifier

10.1159/000180439

Related Literature

Article Analysis
・Side Effects of sulfinpyrazone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.