Paper Details

  1. Home
  2. Paper Details

The role of sulfinpyrazone in the prevention of arterio-venous shunt thrombosis.

Author: GentM, HirshJ, KaegiA, PineoG F, ShimizuA, TrivediH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Sulfinpyrazone was effective in reducing the incidence of thrombosis in patients on chronic hemodialysis. The incidence of thrombosis decreased from 0.64 thrombi per patient month on placebo to 0.21 thrombi per patient month on sulfinpyrazone. Side effects were minimal.
Paper Details　
Original Abstract of the Article :
The effect of sulfinpyrazone on the incidence of thrombosis of arterio-venous shunts was investigated in a double-blind crossover study in 45 patients on chronic hemodialysis over a period of 12 months. The incidence of thrombosis was reduced from 0.64 thrombi per patient month when on placebo to 0....See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1161/01.cir.52.3.497

データ提供：米国国立医学図書館（NLM）

Sulfinpyrazone's Role in Preventing Arterio-Venous Shunt Thrombosis

Arterio-venous shunts, essential for individuals undergoing chronic hemodialysis, can be prone to thrombosis, a serious complication. This study investigates the effectiveness of sulfinpyrazone, a medication known for its antiplatelet properties, in preventing thrombosis of arterio-venous shunts. The authors conducted a double-blind crossover study to assess the impact of sulfinpyrazone on the incidence of shunt thrombosis. Their findings provide compelling evidence for the beneficial role of sulfinpyrazone in preventing this potentially life-threatening complication.

Sulfinpyrazone Demonstrates Significant Effectiveness in Preventing Shunt Thrombosis

This study offers strong evidence that sulfinpyrazone can significantly reduce the incidence of thrombosis in arterio-venous shunts. The observed reduction in thrombosis rates, particularly in men, highlights the potential of sulfinpyrazone as a valuable prophylactic agent for individuals undergoing chronic hemodialysis. These findings underscore the importance of preventative measures in managing this critical aspect of hemodialysis care.

Improving the Safety and Efficacy of Hemodialysis Treatment

This study underscores the importance of ongoing research to find safe and effective ways to manage complications associated with chronic hemodialysis. The findings provide strong support for the use of sulfinpyrazone in preventing shunt thrombosis, potentially improving the safety and efficacy of hemodialysis treatment for individuals reliant on this life-sustaining procedure.

Dr.Camel's Conclusion

Just as a desert traveler needs a reliable compass to navigate the vast landscape, managing chronic hemodialysis requires careful attention to potential complications. This research highlights the importance of sulfinpyrazone in preventing shunt thrombosis, a critical factor in ensuring the safety and efficacy of this life-sustaining treatment. By exploring preventative measures and improving our understanding of this complex procedure, we can improve the quality of life for individuals undergoing chronic hemodialysis.

Date :
  1. Date Completed 1975-11-20
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

1098808

DOI: Digital Object Identifier

10.1161/01.cir.52.3.497

Related Literature

Article Analysis
・Side Effects of sulfinpyrazone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.