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Fully intermittent dosing with drugs for tuberculosis.

Author: MwandumbaH C, SquireS B

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

There is not enough evidence to compare the effectiveness of fully intermittent, rifampicin-containing short-course chemotherapy with similar daily therapy in patients with pulmonary tuberculosis.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The number of people infected with tuberculosis continues to rise world-wide. Rifampicin-containing treatment regimens can achieve high cure rates. Intermittent drug treatment delivered in the community has the potential to improve adherence to treatment. OBJECTIVES: The objective of th...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD000970

データ提供：米国国立医学図書館（NLM）

Evaluating Intermittent Dosing for Tuberculosis Treatment

The global rise in tuberculosis cases poses a significant challenge to public health. This study explores the effectiveness of intermittent dosing, a strategy that delivers medication less frequently, for treating pulmonary tuberculosis. The researchers compared the efficacy of rifampicin-containing short-course chemotherapy regimens given intermittently (two or three times a week) with similar regimens given daily. The results are crucial for informing the optimal treatment strategies for tuberculosis.

Intermittent Dosing for Tuberculosis: Further Research Needed

The study found insufficient evidence to conclude that intermittent dosing is equivalent to daily dosing in terms of cure rates. However, it did highlight a potential increase in relapse rate with intermittent therapy. Further research with larger sample sizes is needed to establish the equivalence of intermittent and daily regimens for pulmonary tuberculosis.

Navigating the Challenges of Tuberculosis Treatment

The study sheds light on the complexities of tuberculosis treatment and the need for more robust evidence to inform clinical practice. As we navigate this challenging disease, understanding the optimal treatment strategies, including the potential benefits and risks of intermittent dosing, is essential.

Dr.Camel's Conclusion

Treating tuberculosis is like navigating a treacherous desert landscape. We must be cautious in our approach, ensuring that our treatment strategies are grounded in sound evidence. This study underscores the need for further research to determine the effectiveness of intermittent dosing, potentially paving the way for more convenient and effective treatment options for this persistent disease.

Date :
  1. Date Completed 2001-08-02
  2. Date Revised 2020-06-20
Further Info :

Pubmed ID

11034692

DOI: Digital Object Identifier

10.1002/14651858.CD000970

SNS
PICO Info
in preparation
Languages

English

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