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Comparison of the effects of zolpidem and triazolam on nocturnal sleep and sleep latency in the morning: a cross-over study in healthy young volunteers.

Author: AkahoR, IchikawaI, KannoO, NakagomeK, NakajimaT, SasakiT, SuzukiM, TakazawaS, WatanabeH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This crossover study compared the effects of zolpidem (ZPD, 10 mg) and triazolam (TRZ, 0.25 mg) on sleep in healthy young subjects. ZPD increased slow-wave sleep (SWS) on the first night, while TRZ increased stage 2 sleep and decreased REM sleep. TRZ withdrawal was associated with increased wakefulness and REM sleep, while ZPD did not affect sleep latency.
Paper Details　
Original Abstract of the Article :
1. Zolpidem (ZPD, 10 mg) was directly compared with triazolam (TRZ, 0.25 mg), a benzodiazepine hypnotic of a short action comparable to ZPD. The compounds were given to healthy young subjects for three nights, in a crossover design. 2. Polysomnographic data of three 150-min sections of the nights as...See full text at original site
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引用元：
https://doi.org/10.1016/s0278-5846(00)00117-2

データ提供：米国国立医学図書館（NLM）

Zolpidem vs. Triazolam: A Head-to-Head Comparison of Sleep Medications

Sleep, a fundamental human need, often becomes a source of frustration when plagued by insomnia. This study delves into the realm of sleep medications, comparing the effects of zolpidem and triazolam on sleep patterns and morning sleepiness.

The researchers conducted a crossover study in healthy young volunteers, comparing the effects of zolpidem and triazolam on sleep architecture and sleep latency. The study found that zolpidem had a more favorable effect on sleep quality, increasing slow wave sleep (SWS) and causing fewer withdrawal effects compared to triazolam. The results highlight the importance of careful selection of sleep medication, considering individual needs and preferences.

Zolpidem: A Potential Solution for Improving Sleep Quality

This study suggests that zolpidem may be a more effective and well-tolerated sleep medication compared to triazolam, offering a promising option for individuals seeking to improve their sleep quality. The study's findings emphasize the importance of personalized sleep medication selection, considering individual needs and preferences.

Navigating the Desert of Sleepless Nights

This research provides valuable insights into the effects of different sleep medications, offering a helpful guide for individuals struggling with insomnia. The study's findings highlight the importance of choosing the right sleep medication to ensure a restful and rejuvenating night's sleep, a journey through the desert of sleepless nights toward a more peaceful morning.

Dr.Camel's Conclusion

This study takes us on a journey through the realm of sleep medications, revealing the distinct effects of zolpidem and triazolam. The study's findings suggest that zolpidem may be a more effective and well-tolerated option, offering a potential oasis in the desert of sleepless nights. It's a reminder that the right sleep medication can make a world of difference in achieving restful sleep and improving overall well-being.

Date :
  1. Date Completed 2001-02-08
  2. Date Revised 2019-09-10
Further Info :

Pubmed ID

11041533

DOI: Digital Object Identifier

10.1016/s0278-5846(00)00117-2

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・Effects of ulipristal・Effects of zolpidem
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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