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Do former smokers respond to nicotine differently from never smokers? A pilot study.

Author: CallasP W, HughesJ R, RoseG L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study found no difference in subjective effects or nicotine reinforcement between former and never smokers after receiving nicotine gum. However, current smokers preferred and self-administered more nicotine than the other groups.
Paper Details　
Original Abstract of the Article :
Nine former, 11 never, and 10 current smokers abstained from smoking for 16 h on each of 4 days. On each of 3 days, participants received three doses per day of 0-, 2-, or 4-mg nicotine gum in a randomized, double-blind, crossover design. To examine subjective effects, participants completed the POM...See full text at original site
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引用元：
https://doi.org/10.1080/14622200050147529

データ提供：米国国立医学図書館（NLM）

A Journey Through the Desert of Nicotine Dependence: Exploring the Effects of Nicotine on Former Smokers

Nicotine dependence is like a mirage in the desert, seemingly offering a quick fix but ultimately leading to a cycle of craving and withdrawal. This pilot study investigates whether former smokers respond differently to nicotine than never smokers. The researchers, like intrepid explorers navigating a desert landscape, conducted a series of experiments to assess the subjective and reinforcing effects of nicotine in different groups of participants. The study found that former and never smokers did not differ in their responses to nicotine, suggesting that the brain's response to nicotine may not be permanently altered by smoking. This finding is like discovering a hidden oasis where the effects of a previous drought are no longer evident.

The Brain's Response to Nicotine: A Tale of Two Deserts

The study's findings, like a map revealing the terrain of the desert, suggest that the brain's response to nicotine may be more flexible than previously thought. The research suggests that the brain's response to nicotine may not be irreversibly altered by smoking, offering a glimmer of hope for those who have quit smoking and are struggling with nicotine cravings. This is like finding a path through the desert that leads to a lush valley, where the harsh effects of the previous journey are no longer felt.

Breaking Free From the Mirage: A New Understanding of Nicotine Dependence

This study offers valuable insights into the nature of nicotine dependence, challenging previous theories about the long-term effects of smoking on the brain. The findings suggest that the brain's response to nicotine may be more malleable than previously believed, offering a ray of hope for those striving to break free from the clutches of this powerful addiction. This is like discovering a new method of navigating the desert, one that allows for a more successful and sustainable journey.

Dr.Camel's Conclusion

This pilot study sheds new light on the effects of nicotine on former smokers, suggesting that the brain's response to nicotine may not be permanently altered by smoking. The findings offer a glimmer of hope for those who have quit smoking and are striving to avoid relapse, suggesting that the path to freedom from nicotine dependence may be more accessible than previously thought.
Date :
  1. Date Completed 2001-05-31
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

11082826

DOI: Digital Object Identifier

10.1080/14622200050147529

Related Literature

Article Analysis
・Effects of nicotine gum
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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