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Pharmacokinetics and pharmacodynamic effects of nicotine nasal spray devices on cardiovascular and pulmonary function.

Author: FishbeinL, FlotteT, HutsonA, O'BrienP, StacpooleP W, TheriaqueD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the hemodynamic and pulmonary effects of nicotine nasal spray in healthy nonsmokers. It found significant changes in both, suggesting potential for adverse effects in non-smokers.
Paper Details　
Original Abstract of the Article :
A nasal spray form of nicotine replacement therapy (Nicotrol NS, McNeil Consumer Products Co, Fort Washington, Pa) has been approved and, because of its rapid absorption across the nasal mucosa, may be more effective than nicotine gum or transdermal patches. We tested the hypothesis that the nicotin...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11094866

データ提供：米国国立医学図書館（NLM）

Nicotine Nasal Spray: A Fast-Acting Route for Nicotine Replacement Therapy

This research investigates the pharmacokinetics and pharmacodynamic effects of nicotine nasal spray (Nicotrol NS) in the context of [Cardiovascular and Pulmonary Function]. Nicotine nasal spray, a newer form of nicotine replacement therapy, promises faster absorption through the nasal mucosa, potentially leading to more effective treatment compared to traditional methods like nicotine gum or patches.

The researchers tested the hypothesis that nicotine absorbed through the nasal mucosa would significantly alter hemodynamics and pulmonary function in a group of healthy, non-smoking individuals. They found that nicotine nasal spray indeed resulted in significant changes in cardiovascular and pulmonary parameters, indicating its rapid and potent effects.

Fast Absorption, Fast Effects: The Impact of Nicotine Nasal Spray

This study confirms the rapid absorption and significant effects of nicotine nasal spray on cardiovascular and pulmonary function. This finding has implications for understanding the therapeutic potential of this delivery method and for optimizing its use for smokers seeking to quit. It's like delivering nicotine directly to the heart of the body, bypassing the digestive system for a quicker and more potent effect.

Nicotine Nasal Spray: A Quick and Powerful Path to Quitting Smoking

For individuals seeking to quit smoking, nicotine nasal spray offers a fast-acting and potentially more effective way to manage nicotine cravings and withdrawal symptoms. It's like a swift camel ride across the desert of nicotine addiction, reaching the oasis of freedom from smoking faster than traditional methods.

Dr. Camel's Conclusion

This research underscores the efficiency of nicotine nasal spray for nicotine replacement therapy. The findings suggest that this delivery method can offer a faster and more effective approach for managing cravings and promoting smoking cessation.

Date :
  1. Date Completed 2000-12-22
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

11094866

DOI: Digital Object Identifier

11094866

SNS
PICO Info
in preparation
Languages

English

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