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Evaluation of the onset and duration of effect of azelastine eye drops (0.05%) versus placebo in patients with allergic conjunctivitis using an allergen challenge model.

Author: FriedlaenderM H, HarrisJ, LaValleeN, RussellH, ShilstoneJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that azelastine eye drops were highly effective in the treatment of experimentally induced allergic conjunctivitis. The onset of action was seen within 3 minutes and the duration of effect was at least 8 to 10 hours.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The trial evaluated the effectiveness of the investigational antihistaminic and antiallergic compound Azelastine Eye Drops (AZE) in the treatment of allergic conjunctivitis using an allergen challenge model. DESIGN: Randomized, double-blind, placebo-controlled, paired-eye study. PARTICI...See full text at original site
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引用元：
https://doi.org/10.1016/s0161-6420(00)00349-3

データ提供：米国国立医学図書館（NLM）

Evaluating Azelastine Eye Drops for Allergic Conjunctivitis

This research delves into the fascinating world of ophthalmology, specifically exploring the efficacy of azelastine eye drops in treating allergic conjunctivitis. Much like a thirsty camel seeking a refreshing oasis, patients with allergic conjunctivitis long for relief from the itching and redness caused by allergens. The study employed a clever allergen challenge model, akin to sending a scout camel into unknown territory, to test the effectiveness of azelastine versus a placebo. The researchers found that azelastine brought relief quickly, with an onset of action within 3 minutes, and its effects lasted for at least 8 to 10 hours - a true testament to its endurance. This research serves as a beacon of hope for those seeking relief from itchy eyes.

Azelastine Proves Effective in Treating Allergic Conjunctivitis

The results of this double-blind, placebo-controlled study clearly demonstrate that azelastine eye drops effectively reduce both itching and redness caused by allergic conjunctivitis. This finding is particularly important considering that allergic conjunctivitis affects a significant number of people, much like a vast desert can be populated by many roaming camels.

Navigating the Desert of Itchy Eyes

For those suffering from allergic conjunctivitis, azelastine eye drops offer a welcome oasis of relief. Remember to consult with an ophthalmologist to determine if this treatment is right for you. By understanding the causes and symptoms of allergic conjunctivitis, we can more effectively navigate the challenges of living in a world full of allergens, just as a seasoned camel navigates the complexities of a vast desert.

Dr. Camel's Conclusion

This study provides strong evidence that azelastine eye drops are a safe and effective treatment for allergic conjunctivitis. The fast onset of action and long-lasting effects offer a valuable solution for individuals seeking relief from itchy eyes.

Date :
  1. Date Completed 2000-12-22
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

11097587

DOI: Digital Object Identifier

10.1016/s0161-6420(00)00349-3

Related Literature

Article Analysis
・Effects of azelastine ophthalmic
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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