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A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group.

Author: AscherJ A, BowdenC L, CalabreseJ R, EarlN L, GreeneP L, KusumakarV, McElroyS L, MonaghanE T, SachsG S, SuppesT, SwannA C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lamotrigine monotherapy may be a useful treatment for some patients with rapid-cycling bipolar disorder. In a study of 324 patients, lamotrigine was well tolerated and showed a statistically significant difference in survival in study compared to placebo.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Patients with rapid-cycling bipolar disorder are often treatment refractory. This study examined lamotrigine as maintenance monotherapy for rapid-cycling bipolar disorder. METHOD: Lamotrigine was added to patients' current psychotropic regimens and titrated to clinical effect during an ...See full text at original site
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引用元：
https://doi.org/10.4088/jcp.v61n1106

データ提供：米国国立医学図書館（NLM）

Lamotrigine: A Potential Treatment for Rapid-Cycling Bipolar Disorder

This study investigates the effectiveness of lamotrigine, an anticonvulsant medication, as a maintenance monotherapy for rapid-cycling bipolar disorder. The researchers explore the use of lamotrigine in a placebo-controlled trial, aiming to assess its efficacy and safety in managing this challenging condition. This research is crucial for finding new and effective treatments for bipolar disorder.

Lamotrigine: A Promising Addition to Treatment Options

The study found that lamotrigine monotherapy was well-tolerated and resulted in a statistically significant difference in survival in study compared to placebo. These findings suggest that lamotrigine may be a useful treatment option for some patients with rapid-cycling bipolar disorder.

Hope for Managing Bipolar Disorder

The study offers a glimmer of hope for individuals with rapid-cycling bipolar disorder, a condition that can be difficult to manage with traditional treatments. The findings suggest that lamotrigine may provide a valuable tool for improving treatment outcomes and enhancing quality of life.

Dr. Camel's Conclusion

This study takes us on an expedition into the complex and often challenging terrain of bipolar disorder. The findings suggest that lamotrigine may offer a new path towards better treatment outcomes and improved well-being. It reminds us that even in the vast and sometimes turbulent desert of mental health, there is always hope for finding effective solutions.

Date :
  1. Date Completed 2001-01-11
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

11105737

DOI: Digital Object Identifier

10.4088/jcp.v61n1106

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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