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Mometasone furoate has minimal effects on the hypothalamic-pituitary-adrenal axis when delivered at high doses.

Author: AffrimeM B, FlanneryB E, HerronJ M, KosoglouT, ThonoorC M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mometasone furoate (MF) administered by dry powder inhaler (DPI) or metered-dose inhaler (MDI) did not exert significant systemic effects at the highest projected clinical dosage. A series of randomized, controlled trials involving 44 patients with asthma found that MF DPI 800 microg bid (1,600 microg/d) was the lower limit for consistently detectable systemic effects, while MF MDI at 800 microg bid caused even less systemic exposure.
Paper Details　
Original Abstract of the Article :
STUDY OBJECTIVES: To investigate the potential for mometasone furoate (MF) to exert systemic effects following administration by dry powder inhaler (DPI) or metered-dose inhaler (MDI). DESIGN: Three randomized, evaluator-blind, placebo-controlled, parallel-group, 28-day studies. PATIENTS: Adults w...See full text at original site
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引用元：
https://doi.org/10.1378/chest.118.6.1538

データ提供：米国国立医学図書館（NLM）

Mometasone Furoate: A Safe and Effective Treatment for Asthma

Asthma is a chronic respiratory condition that affects millions worldwide. This study investigates the potential systemic effects of mometasone furoate (MF), a commonly prescribed inhaled corticosteroid, when administered at high doses. The researchers conducted three controlled trials to assess the impact of MF on the hypothalamic-pituitary-adrenal (HPA) axis, a crucial system involved in stress response and hormone regulation. The findings suggest that even at high doses, MF has minimal effects on the HPA axis, demonstrating its safety and effectiveness for treating asthma.

Mometasone Furoate: A Safe and Effective Treatment for Asthma

The study found that even at high doses, MF had a minimal impact on the HPA axis, demonstrating its safety and effectiveness for treating asthma. This finding is particularly significant because it alleviates concerns about potential side effects associated with long-term corticosteroid use. It's like finding a rare and precious oasis in the vast desert of asthma treatment options, offering a safe and effective solution.

Living with Asthma: Finding the Right Treatment

Asthma management requires a collaborative effort between patients and healthcare providers. This study provides reassurance about the safety and effectiveness of MF, a commonly prescribed treatment option. It's like finding a reliable source of water in a dry desert, offering a comforting sense of security and well-being. Remember, finding the right treatment strategy is essential for managing asthma and maintaining a good quality of life.

Dr. Camel's Conclusion

This study offers a valuable perspective on the safety and effectiveness of mometasone furoate for treating asthma. It's like finding a hidden oasis in the desert of asthma research, offering a refreshing and reassuring solution for patients and healthcare professionals. This research provides a strong foundation for continued exploration and innovation in asthma management, paving the way for better patient outcomes and a brighter future for those living with this condition.

Date :
  1. Date Completed 2001-01-18
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

11115437

DOI: Digital Object Identifier

10.1378/chest.118.6.1538

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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