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Cardiovascular effects of tamoxifen in women with and without heart disease: breast cancer prevention trial. National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial Investigators.

Author: CostantinoJ P, KavanahM, ReisS E, Tan-ChiuE, WangJ, WickerhamD L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

The cardiovascular effects of tamoxifen in women with and without coronary heart disease (CHD) are being investigated in the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (BCPT). This trial is crucial to understand the overall effect of prophylactic tamoxifen, balancing its benefits in preventing breast cancer with potential cardiovascular risks.
Paper Details　
Original Abstract of the Article :
The overall effect of prophylactic tamoxifen in women depends on the balance between the effects of the drug, which include preventing breast cancer and altering cardiovascular risk. In a recent clinical trial, postmenopausal estrogen-progestin therapy was shown to increase the risk of early cardiov...See full text at original site
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引用元：
https://doi.org/10.1093/jnci/93.1.16

データ提供：米国国立医学図書館（NLM）

Tamoxifen: Cardiovascular Effects in Women with and Without Heart Disease

Tamoxifen, a medication commonly used for breast cancer prevention and treatment, can have complex effects on cardiovascular health. This study investigates the cardiovascular effects of tamoxifen in women with and without coronary heart disease (CHD), drawing on data from the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (BCPT). The authors provide insights into the potential cardiovascular risks and benefits of tamoxifen, highlighting the need for careful consideration of individual patient factors when prescribing this medication.

Tamoxifen: Potential Cardiovascular Impact

The study indicates that tamoxifen may have both beneficial and detrimental effects on cardiovascular health. While it can reduce the risk of breast cancer, tamoxifen may also influence cardiovascular risk. The research highlights the importance of considering the potential cardiovascular effects of tamoxifen in women with and without CHD, particularly those who may have underlying cardiovascular risk factors.

Balancing Breast Cancer Prevention with Cardiovascular Health

This study emphasizes the importance of a comprehensive approach to women's health. The research underscores the need to balance the benefits of tamoxifen for breast cancer prevention with its potential cardiovascular effects. Healthcare providers must carefully evaluate individual patient risk factors and discuss the potential benefits and risks of tamoxifen before making treatment decisions.

Dr. Camel's Conclusion

Like a camel navigating a desert with diverse landscapes, healthcare providers must carefully navigate the complex interplay between breast cancer prevention and cardiovascular health. This study investigates the potential cardiovascular effects of tamoxifen, highlighting the importance of individualized risk assessment and informed decision-making. The research emphasizes the need to consider both the benefits and risks of tamoxifen, particularly in women with pre-existing cardiovascular conditions.

Date :
  1. Date Completed 2001-02-22
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

11136837

DOI: Digital Object Identifier

10.1093/jnci/93.1.16

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Languages

English

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