Paper Details

  1. Home
  2. Paper Details

Comparison of the corneal effects of latanoprost, fixed combination latanoprost-timolol, and timolol: A double-masked, randomized, one-year study.

Author: , ErikssonG L, LassJ H, OsterlingL, SimpsonC V

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Latanoprost, fixed-combination latanoprost-timolol, and timolol had similar long-term effects on corneal endothelial cell density and corneal thickness. A double-masked, randomized study involving 369 patients with ocular hypertension or open-angle glaucoma found that after 1 year of treatment, all three drugs showed minimal change in corneal endothelial cell density and corneal thickness.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the long-term effects on corneal endothelial cell density and corneal thickness of latanoprost and the fixed combination latanoprost-timolol to timolol. DESIGN: Double-masked, randomized, prospective, multicenter clinical trial. PARTICIPANTS: Three hundred sixty-nine subjects...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0161-6420(00)00531-5

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Glaucoma Treatment: Comparing Corneal Effects of Latanoprost and Timolol

Glaucoma, a leading cause of irreversible blindness, is a challenging condition to manage. This study compares the long-term effects of two common glaucoma medications: latanoprost and timolol, on corneal health. The researchers embarked on a journey to understand the potential impact of these medications on the delicate landscape of the cornea.

Latanoprost and Timolol: A Comparative Study of Corneal Effects

The study found no significant differences in corneal endothelial cell density or corneal thickness between latanoprost, the fixed combination of latanoprost-timolol, and timolol after one year of treatment. This finding suggests that all three medications have comparable effects on corneal health, offering reassurance for patients and clinicians navigating the desert of glaucoma treatment options.

Finding the Right Oasis: Balancing Effectiveness and Safety

This study provides valuable information for clinicians seeking to manage glaucoma. Understanding the potential effects of different medications on corneal health is crucial for making informed treatment decisions, ensuring that patients receive the most effective therapy while minimizing the risk of side effects. It's like choosing the right path through a desert, considering both the potential for reaching the oasis and the dangers of the surrounding terrain.

Dr.Camel's Conclusion

This study offers a valuable comparison of the corneal effects of latanoprost and timolol, providing important information for clinicians managing glaucoma. While further research is needed to fully understand the long-term impact of these medications on corneal health, this study suggests that all three treatments have comparable effects. By understanding the potential impact of different glaucoma medications, we can navigate the desert of treatment options with greater confidence, finding the right oasis of effectiveness and safety for each individual.

Date :
  1. Date Completed 2001-03-15
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

11158797

DOI: Digital Object Identifier

10.1016/s0161-6420(00)00531-5

Related Literature

Article Analysis
・Effects of timolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.