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Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment.

Author: AshidaY, DendaM, HiraoT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the role of histamine receptors in the skin. In mice, blocking histamine receptors with famotidine, cimetidine, diphenhydramine, and tripelennamine accelerated skin barrier recovery. However, histamine and its agonists delayed recovery. Additionally, these antagonists prevented skin thickening in mice with damaged skin barriers. These findings suggest that both histamine H1 and H2 receptors in the epidermis are involved in skin barrier function and skin thickening.
Paper Details　
Original Abstract of the Article :
Keratinocytes have histamine H1 and H2 receptors, but their functions are poorly understood. To clarify the role of histamine receptors in the epidermis, we examined the effects of histamine receptor antagonists and agonists applied epicutaneously on the recovery of skin barrier function disrupted b...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1046/j.1523-1747.2001.01238.x

データ提供：米国国立医学図書館（NLM）

Histamine Receptors: Guardians of Skin Barrier Function

The skin acts as a vital barrier, protecting us from the outside world. This research explores the role of histamine receptors, located in the epidermis, in maintaining skin barrier function and preventing epidermal hyperplasia.

Histamine Receptors: A Complex Dance of Skin Protection

The study found that histamine H1 and H2 receptor antagonists, when applied topically, accelerated skin barrier repair and prevented epidermal hyperplasia. This suggests that histamine receptors play a crucial role in regulating skin barrier function and potentially preventing skin disorders.

Targeting Histamine Receptors for Skin Health

These findings suggest that targeting histamine receptors could be a promising avenue for developing novel therapies for skin disorders. By modulating the activity of histamine receptors, we might be able to enhance skin barrier function and prevent or treat skin conditions.

Dr.Camel's Conclusion

This research sheds light on the crucial role of histamine receptors in maintaining skin barrier function and preventing epidermal hyperplasia. The study's findings suggest that modulating the activity of histamine receptors could be a promising therapeutic approach for addressing skin disorders. Further research is needed to explore the potential of targeting histamine receptors for improving skin health and treating various skin conditions.

Date :
  1. Date Completed 2001-04-19
  2. Date Revised 2008-11-21
Further Info :

Pubmed ID

11180002

DOI: Digital Object Identifier

10.1046/j.1523-1747.2001.01238.x

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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