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Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial.
Author: BruyereO, DacreJ E, DeroisyR, GiacovelliG, GossettC, HenrotinY, LeeR L, LejeuneE, ReginsterJ Y, RovatiL C
Original Abstract of the Article :
BACKGROUND: Treatment of osteoarthritis is usually limited to short-term symptom control. We assessed the effects of the specific drug glucosamine sulphate on the long-term progression of osteoarthritis joint structure changes and symptoms. METHODS: We did a randomised, double-blind placebo control...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1016/S0140-6736(00)03610-2
データ提供:米国国立医学図書館(NLM)
Long-Term Effects of Glucosamine Sulfate on Osteoarthritis
Osteoarthritis, a condition that affects the joints, is a common ailment, especially in older individuals. While there are treatments that help with symptoms, finding a way to slow down the progression of the disease is a constant quest in the field of rheumatology. This research, like a camel trekking through a vast desert, sought to uncover the long-term impact of glucosamine sulfate on osteoarthritis.
Researchers conducted a randomized, double-blind, placebo-controlled clinical trial, a study design that ensures objectivity. The study followed 212 patients with knee osteoarthritis for three years, a significant time commitment, as they received either glucosamine sulfate or a placebo. The researchers diligently monitored the width of the joint space, a crucial indicator of osteoarthritis progression, and assessed the patients' symptoms using the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index.
The results, much like finding a hidden oasis after a long trek, revealed that glucosamine sulfate showed a significant benefit. Patients on the placebo experienced progressive joint-space narrowing, indicating worsening osteoarthritis, while those taking glucosamine sulfate did not. Glucosamine sulfate also alleviated symptoms, as measured by the WOMAC score, while the placebo group showed a slight worsening of their condition.
The Promise of Disease Modification
These findings are promising because they suggest that glucosamine sulfate might not only manage symptoms but also potentially modify the progression of osteoarthritis. This is a significant step towards a more comprehensive approach to managing this common disease.
A glimmer of hope for Osteoarthritis
The research paints a hopeful picture for those living with osteoarthritis. It suggests that glucosamine sulfate could potentially play a role in slowing down the progression of the disease and improving symptoms. While further research is needed to fully understand its long-term effects, this study provides valuable insight into the potential of glucosamine sulfate as a disease-modifying agent.
Dr.Camel's Conclusion
This study provides evidence that glucosamine sulfate may be a valuable tool in managing osteoarthritis. While more research is needed, the results suggest that it could potentially modify the course of the disease, much like a camel adapting to the harsh desert environment. This is exciting news for those seeking to slow the progression of osteoarthritis and improve their quality of life.
Date :
- Date Completed 2001-02-22
- Date Revised 2022-04-09
Further Info :
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