Paper Details 
Original Abstract of the Article :
The effects of frovatriptan and sumatriptan on internal carotid and coronary vascular haemodynamics were investigated and compared in conscious dogs. Frovatriptan and sumatriptan (0.1 - 100 microg kg(-1)) induced a transient increase in external coronary artery diameter (eCOD) of up to 2.9+/-1.2 and...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572655/

データ提供:米国国立医学図書館(NLM)

Frovatriptan and Sumatriptan: Effects on Vascular Haemodynamics

This study examines the comparative effects of frovatriptan and sumatriptan, both triptan medications used for migraine treatment, on coronary and internal carotid vascular haemodynamics in conscious dogs. The research uses a controlled experimental design to assess the impact of these medications on blood vessel diameter and blood flow. The authors found that both triptans initially dilated and subsequently constricted large coronary arteries, while directly constricting the internal carotid artery. However, frovatriptan was more potent than sumatriptan at both coronary and carotid arteries. This research provides valuable insights into the vascular effects of these medications, contributing to a better understanding of their mechanisms of action and potential cardiovascular effects.

Triptans and Vascular Haemodynamics: A Detailed Look

The study sheds light on the complex vascular effects of triptans, particularly their impact on coronary and carotid arteries. The findings indicate that these medications can influence both blood vessel dilation and constriction, highlighting the need for careful consideration of their potential cardiovascular effects, especially in individuals with pre-existing cardiovascular conditions. Further research is warranted to understand the long-term implications of these findings.

Taking Triptans: Understanding Potential Cardiovascular Effects

This research reminds us that medications can have diverse effects on our bodies, including our vascular system. If you are taking triptans, it's important to discuss your individual risk factors and potential cardiovascular effects with your healthcare provider. Open communication and a proactive approach to managing your health are essential.

Dr.Camel's Conclusion

Just as a camel’s blood vessels adapt to the changing conditions of the desert, so too do our blood vessels react to medications. This research explores the intricate dance between triptans and our vascular system, reminding us to be mindful of potential effects and consult with our healthcare providers for personalized advice.

Date :
  1. Date Completed 2001-06-21
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

11226138

DOI: Digital Object Identifier

PMC1572655

Related Literature

SNS
PICO Info
in preparation
Languages

English

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