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Comparison of the effects of clonidine and hydroxyzine on haemodynamic and catecholamine reactions to microlaryngoscopy.

Author: BoussofaraM, BraccoD, RavussinP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Clonidine premedication significantly decreased mean arterial pressure during and after microlaryngoscopy but did not affect heart rate or plasma catecholamine levels compared to hydroxyzine.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND OBJECTIVE: This study compares the effect of oral clonidine vs. hydroxyzine on the haemodynamic and catecholamine responses to microlaryngoscopy. METHODS: Thirty-five ASA II-III patients were included in this double-blind randomized trial. The patients received either hydroxyzine 1 m...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2346.2001.00782.x

データ提供：米国国立医学図書館（NLM）

Premedication: A Key to Managing Haemodynamic Responses in Microlaryngoscopy

Microlaryngoscopy, a procedure involving examination of the larynx, can evoke significant haemodynamic responses, much like navigating a desert with its unpredictable temperature shifts. This research investigates the effects of two premedication drugs, clonidine and hydroxyzine, on haemodynamic and catecholamine responses during microlaryngoscopy. The study involved a double-blind randomized trial comparing the effects of these medications on patients undergoing the procedure.

Clonidine: A Potential Ally in Haemodynamic Control

The study revealed that clonidine significantly decreased mean arterial pressure during and after microlaryngoscopy. This finding, like discovering a cool spring in the desert, suggests that clonidine may be an effective premedication option for controlling haemodynamic responses during this procedure. However, the study found no significant differences in heart rate or plasma catecholamine levels between the clonidine and hydroxyzine groups.

Navigating the Procedure with Precision

This research provides valuable insights into the management of haemodynamic responses during microlaryngoscopy. It highlights the potential benefits of clonidine as a premedication agent, offering a more stable and controlled environment for the procedure. This study, like a well-mapped route across a desert, underscores the importance of carefully considering premedication options to optimize patient care and ensure a smoother procedure.

Dr. Camel's Conclusion

This research offers a clear path through the desert of microlaryngoscopy, highlighting the potential of clonidine as a premedication agent to manage haemodynamic responses. This study provides valuable insights for clinicians seeking to optimize patient care during this procedure, ensuring a smoother and more controlled experience for both the patient and the medical team.

Date :
  1. Date Completed 2001-05-10
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

11270028

DOI: Digital Object Identifier

10.1046/j.1365-2346.2001.00782.x

Related Literature

Article Analysis
・Effects of hydroxyzine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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