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A comparison of two opioid analgesics for relief of visceral pain induced by intestinal resection in rats.

Author: ClarkM D, DahlyE M, GillinghamM B, Krugner-HigbyL A, NeyD M

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study evaluated the effectiveness of buprenorphine versus oxymorphone to alleviate the pain induced by intestinal resection in rats. Rats treated with oxymorphone exhibited behavior and appearance similar to their preoperative state, while rats treated with buprenorphine exhibited behavior and appearance consistent with pain and distress for as long as 32 h postoperatively. Oxymorphone alleviated the pain-related behavioral changes after intestinal resection far better than did buprenorphine.
Paper Details　
Original Abstract of the Article :
While developing a rat model for human short bowel syndrome, we noted that untreated rats as well as rats administered buprenorphine after intestinal resection exhibited behavior and appearance consistent with visceral pain and distress. To provide appropriate analgesics, we developed criteria to as...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/11300671

データ提供：米国国立医学図書館（NLM）

Finding the Right Opioid for Visceral Pain: Oxymorphone Takes the Lead

Visceral pain, pain originating from internal organs, can be a challenging condition to treat. This study compared the effectiveness of two opioid analgesics, buprenorphine and oxymorphone, in alleviating visceral pain induced by intestinal resection in rats. The researchers developed a rigorous pain assessment protocol to evaluate the analgesic efficacy of these drugs.

Oxymorphone: A Superior Analgesic for Visceral Pain

The study found that oxymorphone was significantly more effective in alleviating visceral pain after intestinal resection in rats than buprenorphone. This finding suggests that oxymorphone may be a superior analgesic option for managing visceral pain in clinical settings.

Effective Pain Management: Choosing the Right Opioid

This research underscores the importance of selecting the appropriate opioid for managing visceral pain. While buprenorphone is a commonly used opioid, the study suggests that oxymorphone might offer a more effective solution for certain types of pain. However, it's essential to consult with a healthcare professional to determine the most suitable analgesic based on individual needs and medical history.

Dr.Camel's Conclusion

Just as a camel carefully chooses its path across the desert, selecting the right opioid for pain relief is crucial. This study demonstrates the superiority of oxymorphone in managing visceral pain, providing valuable insights into the complex world of analgesics and pain management.

Date :
  1. Date Completed 2001-08-30
  2. Date Revised 2016-10-21
Further Info :

Pubmed ID

11300671

DOI: Digital Object Identifier

11300671

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Article Analysis
・Effects of buprenorphine injection (pain relief)
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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