Amoxicillin-clavulanic acid therapy may be associated with severe side effects -- review of the literature.

Author: GresserU

Paper Details 
Original Abstract of the Article :
INTRODUCTION: There is a growing body of evidence that amoxicillin-clavulanic acid may induce severe adverse effects in patients. METHODS: A medline search of case reports and reviews on amoxicillin-clavulanic acid induced adverse effects was performed. The criteria of a consensus conference on the...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/11309226

データ提供:米国国立医学図書館(NLM)

Amoxicillin-Clavulanic Acid: A Double-Edged Sword for Infections

This research delves into the potential adverse effects associated with amoxicillin-clavulanic acid, a common antibiotic. The study analyzed a significant number of case reports, revealing that this medication can cause severe side effects, including drug-induced cholestatic hepatitis. A total of 208 patients were identified with this adverse effect, with a mean age of 60 years. The study revealed that the majority of patients had been treated for respiratory tract infections and sinusitis with amoxicillin-clavulanic acid, often for an extended period of 13.9 days. This highlights the importance of cautious use and careful monitoring of liver function, particularly in patients on multi-drug regimens.

A Desert Oasis With a Hidden Sting

This study reveals the potential for amoxicillin-clavulanic acid to cause serious complications, emphasizing the need for careful consideration when prescribing this medication. Imagine a desert oasis offering respite from the heat and thirst, but the water source is contaminated. Amoxicillin-clavulanic acid, like this oasis, can provide relief from infections, but it may also harbor hidden risks.

Navigating the Risks of Antibiotic Treatment

This research reminds us that even common medications can have unexpected consequences. It is crucial to be aware of the potential risks associated with antibiotic treatment, especially when using combinations or for extended durations. Just as a camel caravan must choose its path carefully in a desert, so too must we navigate the potential dangers associated with medications.

Dr.Camel's Conclusion

This study underscores the importance of careful consideration and monitoring when prescribing amoxicillin-clavulanic acid, particularly in patients with pre-existing liver conditions or those on multiple medications. Like a wise camel navigating a treacherous desert landscape, healthcare professionals must be aware of the potential risks and ensure that the benefits of this medication outweigh its potential drawbacks.
Date :
  1. Date Completed 2001-07-12
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

11309226

DOI: Digital Object Identifier

11309226

Related Literature

SNS
PICO Info
in preparation
Languages

English

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