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The effects of different repeated doses of entacapone on the pharmacokinetics of L-Dopa and on the clinical response to L-Dopa in Parkinson's disease.

Author: GordinA, HeikkinenH, KollerW C, LeWittP A, NuttJ G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Entacapone, a COMT inhibitor, effectively reduced the levels of 3-OMD, increasing the bioavailability of L-Dopa and potentially improving clinical outcomes in Parkinson's disease patients with levodopa-related fluctuations.
Paper Details　
Original Abstract of the Article :
We performed a double-blind, placebo-controlled, randomized, crossover, multiple-dose study on entacapone in 25 patients with Parkinson's disease with levodopa (L-Dopa) treatment-related fluctuations. A run-in period was followed by four 2-week treatment periods during which the patients took 4 to 6...See full text at original site
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引用元：
https://doi.org/10.1097/00002826-200105000-00006

データ提供：米国国立医学図書館（NLM）

Entacapone: A Camel's Oasis for Parkinson's Disease

The world of [Parkinson's disease] is often marked by frustrating fluctuations in symptoms. This study investigates the effects of [entacapone], a medication used to manage Parkinson's disease, on the body's response to levodopa, a key treatment for the condition. It's like a camel traversing a desert, seeking a stable source of water to sustain its journey. This research involved 25 patients with Parkinson's disease who experienced fluctuations in their response to levodopa treatment. The study evaluated the impact of different doses of entacapone on the pharmacokinetics of levodopa and the patients' clinical response. The results demonstrated that entacapone effectively reduced the breakdown of levodopa, leading to more sustained and consistent therapeutic effects.

Sustaining the Journey: Entacapone's Impact

Entacapone, in this study, acted like a trusty guide for the camel, ensuring a steady supply of water. The study showed that entacapone significantly reduced the breakdown of levodopa, leading to improved and more predictable control of Parkinson's symptoms. This positive effect was observed across different doses, suggesting that entacapone could be a valuable tool for managing Parkinson's disease.

Finding Balance in the Desert of Parkinson's

This research highlights the importance of maintaining a balance in the treatment of Parkinson's disease. It's like a camel navigating a desert, always searching for that delicate equilibrium between thirst and dehydration. Entacapone offers a promising approach to manage the fluctuations in levodopa effectiveness, providing a more stable and comfortable journey for individuals with Parkinson's. This study emphasizes the need for personalized treatment strategies tailored to individual needs.

Dr.Camel's Conclusion

Entacapone emerges as a valuable ally in the fight against Parkinson's disease. By reducing the breakdown of levodopa, it can help to smooth out the fluctuations in symptoms, providing a more consistent and manageable experience for patients. This research reinforces the importance of finding the right balance in treatment and underscores the potential benefits of entacapone in improving the lives of individuals with Parkinson's disease.

Date :
  1. Date Completed 2001-10-04
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

11391126

DOI: Digital Object Identifier

10.1097/00002826-200105000-00006

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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