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Bioavailability of the oral selective phosphodiesterase 4 inhibitor cilomilast.

Author: BirrellC, CarrA, ClarkD J, DavieC C, KellyJ, MurdochR D, QuinlanJ, RitchieS Y, SchofieldJ P, WallsC, WebberD, ZussmanB D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Oral cilomilast had an absolute bioavailability of 100% and was not adversely affected by food, dosing time, or coadministration with antacid.
Paper Details　
Original Abstract of the Article :
STUDY OBJECTIVE: To determine the absolute bioavailability of cilomilast, and assess the effects of food, dosing time, and coadministration of antacid agents on its bioavailability and pharmacokinetics in healthy volunteers. SETTING: Clinical pharmacology unit. DESIGN: Five prospective pharmacokin...See full text at original site
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引用元：
https://doi.org/10.1592/phco.21.7.653.34569

データ提供：米国国立医学図書館（NLM）

Bioavailability of Cilomilast: A Phosphodiesterase 4 Inhibitor

The search for effective and safe [phosphodiesterase 4 (PDE4) inhibitors] for treating various conditions is ongoing. This study investigates the [bioavailability] of [cilomilast], a novel PDE4 inhibitor. Researchers conducted a series of pharmacokinetic studies in healthy volunteers to determine the influence of various factors, including [food], [dosing time], and [antacid agents], on cilomilast's absorption and metabolism. It's like studying the effects of different types of sand dunes on the movement of a camel caravan - understanding these variables can help to optimize the journey.

Cilomilast: High Bioavailability and Minimal Impact of Food

The study found that cilomilast exhibits high absolute bioavailability, meaning that it is effectively absorbed into the bloodstream when taken orally. Furthermore, food intake had minimal impact on cilomilast's absorption and metabolism. This finding suggests that cilomilast can be taken with or without food, making it a convenient option for patients. It's like a camel that can navigate both sandy and rocky terrain, adapting easily to different environments.

Cilomilast: A Promising PDE4 Inhibitor for Various Conditions

This research provides valuable information about the pharmacokinetics of cilomilast, a promising PDE4 inhibitor with potential applications in treating various conditions, such as [chronic obstructive pulmonary disease (COPD)]. The high bioavailability and minimal impact of food on its absorption make it a convenient and effective treatment option. As a wise camel, I always say, it's important to find a path that is both efficient and comfortable.

Dr.Camel's Conclusion

This study demonstrates the high bioavailability of cilomilast, a PDE4 inhibitor, and suggests that its absorption is minimally affected by food intake. These findings support the use of cilomilast as a convenient and effective treatment option for various conditions.

Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

11401178

DOI: Digital Object Identifier

10.1592/phco.21.7.653.34569

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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