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Cure of Helicobacter pylori infection in elderly patients: comparison of low versus high doses of clarithromycin in combination with amoxicillin and pantoprazole.

Author: BozzolaL, Di MarioF, FranceschiM, LeandroG, PilottoA, RassuM, SoffiatiG, ValerioG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Clarithromycin at the lower dose of 250 mg b.d. achieved excellent cure rates and minimized adverse events and costs in elderly patients with H. pylori-associated ulcer disease or chronic gastritis.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Advancing age may influence clarithromycin's pharmacokinetics. No studies have yet compared the effects of different dosages of clarithromycin in combination with a proton pump inhibitor and amoxicillin in elderly patients. AIM: To compare the efficacy and tolerability of clarithromycin...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1046/j.1365-2036.2001.01008.x

データ提供：米国国立医学図書館（NLM）

Clarithromycin Dosing for Helicobacter pylori Infection in Elderly Patients

Helicobacter pylori (H. pylori) infection is a common cause of [ulcer disease and chronic gastritis]. Treatment typically involves [triple therapy] with a proton pump inhibitor, amoxicillin, and clarithromycin. However, the effectiveness of clarithromycin in elderly patients is not fully understood, particularly regarding different dosages. This study compares the efficacy and tolerability of [low-dose (250 mg) versus high-dose (500 mg)] clarithromycin in combination with pantoprazole and amoxicillin for treating H. pylori infection in elderly patients.

Finding the Right Dose: Optimizing Treatment for Elderly Patients with H. pylori

The study found that both [low-dose and high-dose clarithromycin regimens] achieved similar cure rates for H. pylori infection in elderly patients. While the high-dose regimen had a slightly higher rate of [adverse events], the difference was not statistically significant. The study suggests that the [lower dose of clarithromycin] may be more cost-effective and minimize adverse events without compromising treatment efficacy.

Helicobacter pylori Treatment: Considerations for Elderly Patients

This study provides valuable insights for treating H. pylori infection in elderly patients, suggesting that a lower dose of clarithromycin can be just as effective as a higher dose. It's important to remember that individual responses to treatment vary, and healthcare professionals should consider patient factors, such as age and medical history, when selecting the most appropriate treatment regimen.

Dr. Camel's Conclusion

This study explores the efficacy and tolerability of different clarithromycin doses for treating Helicobacter pylori infection in elderly patients. The findings suggest that a lower dose may be equally effective with fewer side effects. This research highlights the importance of considering patient factors when choosing the most appropriate treatment approach. As a wise camel, I always emphasize the importance of consulting with healthcare professionals to ensure you receive the best possible care for your individual needs.

Date :
  1. Date Completed 2001-08-09
  2. Date Revised 2019-09-01
Further Info :

Pubmed ID

11421879

DOI: Digital Object Identifier

10.1046/j.1365-2036.2001.01008.x

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Article Analysis
・Effects of clarithromycin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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