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Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV disease.

Author: , AssmannS F, CollierA C, FlaniganT P, KalishL A, KumarP N, MintzL, MurphyE L, NemoG J, ParaM F, WallachF R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Highly active antiretroviral therapy (HAART) was associated with an independent reduction in mortality and opportunistic events in HIV-infected patients with advanced AIDS and anemia, even in those with very low CD4(+) counts. However, HAART did not reduce new CMV events in patients with CMV infection or disease.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Mortality and morbidity related to AIDS have decreased among HIV-infected patients taking highly active anti-retroviral therapy (HAART), but previous studies may have been confounded by other changes in treatment. OBJECTIVE: To assess the benefit of HAART in patients with advanced AIDS ...See full text at original site
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引用元：
https://doi.org/10.7326/0003-4819-135-1-200107030-00005

データ提供：米国国立医学図書館（NLM）

The Impact of Highly Active Antiretroviral Therapy on Advanced HIV Disease

The fight against HIV/AIDS is an ongoing journey, filled with breakthroughs and challenges. This study explores the impact of highly active antiretroviral therapy (HAART) on patients with advanced HIV disease. The researchers conducted a comprehensive prospective cohort study, evaluating the effects of HAART on mortality and morbidity in a group of patients with advanced AIDS and anemia.

A Beacon of Hope in the Battle Against HIV

The study's results provide a glimmer of hope in the fight against HIV/AIDS. HAART demonstrated a significant reduction in both mortality and opportunistic infections, even in patients with very advanced HIV disease. The researchers observed a dramatic decrease in death rates among patients receiving HAART compared to those not receiving it. The study's findings suggest that HAART can have a profound impact on the lives of individuals living with advanced HIV disease, improving their quality of life and extending their lifespan.

Staying Vigilant in the Desert of HIV

While the results are encouraging, the study also points out that HAART may not fully prevent new cytomegalovirus (CMV) events. This suggests that further research is needed to optimize treatment strategies for patients with CMV infection or disease. The study serves as a reminder that even in the face of significant progress, the battle against HIV remains a complex and ongoing endeavor.

Dr.Camel's Conclusion

This study is a testament to the power of scientific innovation in combating a formidable foe like HIV. HAART has emerged as a powerful weapon in this battle, offering a lifeline to those with advanced HIV disease. However, as we continue our journey, we must remain vigilant, always seeking new ways to combat this relentless adversary and provide comprehensive care to those affected. The desert of HIV may be vast, but with continued research and dedication, we can find new oases of hope.

Date :
  1. Date Completed 2001-07-26
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

11434728

DOI: Digital Object Identifier

10.7326/0003-4819-135-1-200107030-00005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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